Colchicine’s Role in Cardiovascular Disease Management

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2024, Volume and Issue: 44(5), P. 1031 - 1041

Published: March 21, 2024

Colchicine—an anti-inflammatory alkaloid—has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use ancient Egypt. Primarily used high doses for treatment acute gout flares during 20th century, research early 21st century demonstrated that low-dose colchicine effectively treats attacks, lowers risk recurrent pericarditis, and can add to secondary prevention major adverse events. As Food Drug Administration–approved targeted therapy, currently has a unique atherosclerotic disease. The safe requires careful monitoring drug-drug interactions, changes kidney liver function, counseling regarding gastrointestinal upset. Future should elucidate mechanisms effects relevant atherosclerosis, potential primary prevention, other cardiometabolic conditions, colchicine’s safety patients, opportunities individualizing therapy using clinical molecular diagnostics.

Language: Английский

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Atherosclerosis and the Bidirectional Relationship Between Cancer and Cardiovascular Disease: From Bench to Bedside, Part 2 Management

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 334 - 334

Published: Jan. 2, 2025

The first part of this review highlighted the evolving landscape atherosclerosis, noting emerging cardiometabolic risk factors, growing impact exposomes, and social determinants health. prominent role atherosclerosis in bidirectional relationship between cardiovascular disease cancer was also discussed. In second part, we examine complex interplay multimorbid cardio-oncologic patients, harmful environments that lend a “syndemic” nature to these chronic diseases. We summarize management strategies targeting disordered factors mitigate explore molecular mechanisms enabling more tailored therapies. Importantly, emphasize early interception through multifactorial interventions detect subclinical signs (via biomarkers imaging) treat modifiable prevent clinical events. A concerted preventive effort—referred by some as “preventome”—is essential reduce burden atherosclerosis-driven diseases, shifting from mere proactive promotion “chronic health”.

Language: Английский

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Genomic instability and genetic heterogeneity in aging: insights from clonal hematopoiesis (CHIP), monoclonal gammopathy (MGUS), and monoclonal B-cell lymphocytosis (MBL)

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Aging is a multifaceted process characterized by gradual decline in physiological function and increased susceptibility to range of chronic diseases. Among the molecular cellular mechanisms driving aging, genomic instability fundamental hallmark, contributing mutation load genetic heterogeneity within populations. This review explores role aging hematopoietic system, with particular focus on clonal hematopoiesis indeterminate potential (CHIP), monoclonal gammopathy undetermined significance (MGUS), B-cell lymphocytosis (MBL) as biomarkers. CHIP involves expansion stem cells somatic mutations. In contrast, MGUS presence plasma producing immunoglobulins, while MBL proliferation B cells. These conditions are prevalent population serve measurable indicators underlying instability. Studying these entities offers valuable insights into which mutations accumulate drive evolution providing deeper understanding how impacts tissue homeostasis. summary, system serves powerful model for investigating interplay between aging. Incorporating age-related hematological research, alongside other biomarkers such epigenetic clocks, can enhance precision predictive power biological age assessments. provide comprehensive view process, facilitating early detection diseases hopefully enabling personalized healthcare strategies.

Language: Английский

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Clonal Haematopoiesis of Indeterminate potential and Cardiovascular diseases : A review

Indian Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

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Clonal hematopoiesis of indeterminate potential: recent developments and perspectives

Current Opinion in Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Purpose of review This encompasses the recently published information on clonal hematopoiesis indeterminate potential (CHIP) and discusses its future prospects. By announcing advances in research CHIP risk factors related diseases, with purpose offering new insights to treat both hematologic nonhematologic disorders. Recent findings The majority studies have shown that is a common biological condition associated aging incidence increases age. pathophysiology blood diseases projected be significantly influenced by CHIP. Nevertheless, increasing expanded application cover such as cardiovascular, renal, liver, pulmonary diseases. Furthermore, fast advancement genetic testing technology preventive medicine, involvement variety disorders shows promise an essential target for preventing disease onset progression. Summary linked illnesses has significant influence individual's health outlook. Thus, identifying managing critical improving clinical results individuals concerned.

Language: Английский

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Clonal haematopoiesis of indeterminate potential: an emerging risk factor for type 2 diabetes and related complications

Diabetologia, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

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CHIP: Molekulare Mechanismen, Diagnostik und therapeutische Implikationen

Trillium Diagnostik, Journal Year: 2025, Volume and Issue: 23(1), P. 17 - 20

Published: March 20, 2025

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Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

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Clonal Hematopoiesis and Thrombosis

American Journal of Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

ABSTRACT Clonal hematopoiesis (CH) has been the focus of many research efforts in last years and emerged as a risk modifier for cardiovascular disease morbidity mortality. While substantial evidence accumulated regarding its impact on arterial system diseases, connection with venous thrombosis only recently explored. Both clinical preclinical suggest that magnitude mechanism underlying association CH events vary depending specific mutated gene involved, indicating causal link between development, not system, particularly context atherosclerosis, but also thrombosis. Although this growing body knowledge driven translational provided insights improving management, several questions remain unanswered. This review aims to summarize available thrombosis, while highlighting gaps need be addressed future research.

Language: Английский

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