Concurrent Transmission of Zika Virus During the 2023 Dengue Outbreak in Bangladesh DOI
Anamul Hasan, Md. Mobarok Hossain,

Md Fahad Zamil

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract Background During the 2023-dengue outbreak in Bangladesh, a diagnostic evaluation study was conducted to investigate concurrent Zika virus (ZIKV) and dengue (DENV) transmission Dhaka 2023. Aims The explored simultaneously detect presence of ZIKV, DENV, and/or CHIKV while considering relevant clinical epidemiological risk factors, using real-time multiplex RT-PCR system. Following this, it planned sequence selected samples identify genetic variations ZIKV infections within population. Methods This designed as evaluation, where participants meeting inclusion criteria were prospectively recruited with written informed consent. A total 399 febrile individuals screened, 185 having fever onset 2 – 5 days, along one following features, e.g. headache, myalgia, arthralgia or bone pain, rash, nausea, vomiting, diarrhea 152 undergoing testing. Results Five ZIKV-positive cases identified, including DENV-ZIKV co-infection. Phylogenetic analysis revealed strains part Asian lineage, closely related Cambodian Chinese from 2019. All male, residing one-kilometer radius, no prior travel history, suggesting community-level transmission. Conclusion marks first identification city report ZIKV-DENV co-infection Bangladesh that highlights challenges posed by symptomatic similarities between other arboviruses underscores need for enhanced surveillance public health interventions mitigate spread impact dengue-endemic regions. Synopsis explores co-transmission during 2023 shedding light on important issues. While is typically mild illness most people, can have serious neurological consequences, such microcephaly infants. Dengue, another mosquito-borne common tropical regions like affects significant portion research stands out because recorded instance Zika-Dengue country. discovery crucial both local global communities, challenge managing outbreaks similar viruses at same time, complicating diagnosis treatment. calls stronger better measures manage these viruses, particularly densely populated areas illnesses rapidly. work focuses importance raising awareness enhancing disease management practices reduce risks infections. overlap symptoms potentially outcomes vulnerable groups, pregnant women newborns, make understanding Zika’s critical. These insights guide future efforts vaccine development community level.

Language: Английский

Concurrent transmission of Zika virus during the 2023 dengue outbreak in Dhaka, Bangladesh DOI Creative Commons
Anamul Hasan, Md. Mobarok Hossain,

Md Fahad Zamil

et al.

PLoS neglected tropical diseases, Journal Year: 2025, Volume and Issue: 19(1), P. e0012866 - e0012866

Published: Jan. 30, 2025

Background During the 2023-dengue outbreak in Bangladesh, a diagnostic evaluation study was conducted to investigate concurrent Zika virus (ZIKV) and dengue (DENV) transmission Dhaka 2023. Aims The explored simultaneously detect presence of ZIKV, DENV, and/or CHIKV while considering relevant clinical epidemiological risk factors, using real-time multiplex RT-PCR system. Following this, it planned sequence selected samples identify genetic variations ZIKV infections within population. Methods This designed as evaluation, where participants meeting inclusion criteria were prospectively recruited with written informed consent. A total 399 febrile individuals screened, 185 having fever onset 2–5 days, along one following features, e.g. headache, myalgia, arthralgia or bone pain, rash, nausea, vomiting, diarrhea 152 undergoing testing. Results Five ZIKV-positive cases identified, including DENV-ZIKV co-infection. Phylogenetic analysis revealed strains part Asian lineage, closely related Cambodian Chinese from 2019. All male, residing one-kilometer radius, no prior travel history, suggesting community-level transmission. Conclusion marks first identification city report ZIKV-DENV co-infection Bangladesh that highlights challenges posed by symptomatic similarities between other arboviruses underscores need for enhanced surveillance public health interventions mitigate spread impact dengue-endemic regions.

Language: Английский

Citations

1
A Narrative Review on the Pandemic Zoonotic RNA Virus Infections Occurred During the Last 25 Years DOI Creative Commons
Gobena Ameni, Aboma Zewude, Begna Tulu

et al.

Journal of Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Pandemic zoonotic RNA virus infections have continued to threaten humans and animals worldwide. The objective of this review was highlight the epidemiology socioeconomic impacts pandemic that occurred between 1997 2021. Literature search done from Web Science, PubMed, Google Scholar Scopus databases, cumulative case fatalities individual viral infection calculated, geographic coverage pandemics were shown by maps. Seven major 2021 presented in three groups: first group consists highly pathogenic avian influenza (HPAI-H5N1) swine-origin (H1N1) viruses with fatality rates 53.5% 0.5% humans, respectively. Moreover, HPAI-H5N1 caused 90–100% death poultry economic losses >$10 billion Similarly, H1N1 a serious swine 0.5-1.5% Gross Domestic Product (GDP) affected countries. second severe acute respiratory syndrome-associated coronavirus (SARS-CoV), Middle East Respiratory Syndrome (MERS-CoV) Coronavirus disease 2019 (COVID-19) 9.6%, 34.3% 2.0%, respectively humans; but only mild animals. third Ebola Zika 39.5% 0.02%, causing Similar are expected near future, hence strict implementation conventional biosecurity-based measures development efficacious vaccines would help minimize next infection.

Language: Английский

Citations

5
Modelling the impact and cost-effectiveness of upcoming Zika virus vaccines on congenital Zika syndrome DOI Creative Commons
He Song, Shihui Jin,

Bing Yang

et al.

Vaccine, Journal Year: 2025, Volume and Issue: 48, P. 126728 - 126728

Published: Jan. 16, 2025

Language: Английский

Citations

0
Inactivation of Zika Virus with Hydroxypropyl-Beta-Cyclodextrin DOI Creative Commons
Cory Hewitt,

Nicholas Wixon,

Arthur Gallegos

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(1), P. 79 - 79

Published: Jan. 16, 2025

Background/Objectives: Zika virus (ZIKV) infection is associated with life-threatening diseases in humans. To date, there are no available FDA-approved therapies or vaccines for the specific treatment prevention of ZIKV infection. Variation envelope protein (Env), along its complex quaternary structure, presents challenges to synthetic approaches developing an effective vaccine and broadly neutralizing antibodies (bnAbs). We hypothesized that beta-cyclodextrin (BCD) could be used uniquely inactivate infectious without disruption Env. Methods: was propagated Vero cells admixed BCD. The BCD-treated evaluated infectivity using immunofluorescence quantitative RT-PCR (qRT-PCR) assays, immunoreactivity Western blots, structural integrity by electron microscopy, immunogenicity mice. Results: Here, we show 200 mM non-infectious cell culture, remains immunoreactive Env-specific antibody, retains virion shape size, elicits production immunogen-specific immunized Conclusions: These results indicate BCD can safely ZIKV, they provide insights antibody development.

Language: Английский

Citations

0
Discovery of Arylfuran and Carbohydrate Derivatives from the BraCoLi Library as Potential Zika Virus NS3pro Inhibitors DOI Creative Commons
Fernanda Kelly Marcelino e Oliveira,

Beatriz Murta Rezende Moraes Ribeiro,

Ellen Gonçalves de Oliveira

et al.

Future Pharmacology, Journal Year: 2025, Volume and Issue: 5(1), P. 9 - 9

Published: Feb. 15, 2025

Background/Objectives: Zika fever is a disease caused by the virus (ZIKV). Symptomatic cases may be associated with neurological disorders in adults, as well congenital syndrome and other birth defects during pregnancy. In 2016, was considered public health problem World Health Organization (WHO), highlighting need to develop new therapies against disease. Currently, there no antiviral or vaccine available treat prevent severe cases. Due lack of therapeutics few promising hit molecules, we computationally screened well-described ZIKV protease (NS3pro) drug target revisit small-molecule database Brazilian Compound Library (BraCoLi) select potential inhibitors. Methods: We employed consensus docking screening library 1176 compounds using GOLD DockThor. selected 28 hits based on predicted binding affinity, only remnants three were at time this study for experimental validation. The evaluated their cytotoxic (CC50) effective concentrations (EC50) activity Vero cells. Results: presented modest CC50 values 89.15 ± 3.72, >100, 29.67 1.01 μM, latter, carbohydrate derivative, having an EC50 value >12.5 μM (~40% inhibition) PE243. Additionally, essentially non-toxic compound, arylfuran also inhibited NS3pro IC50 17 but evidence acting through promiscuous mechanism enzyme inhibition. Conclusion: This highlights relevance revisiting existing assets identify novel therapeutic starting points ZIKV, aiming lead candidates future.

Language: Английский

Citations

0
Toll-like receptor response to Zika virus infection: progress toward infection control DOI Creative Commons
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama‐Kohara

et al.

npj Viruses, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 13, 2025

Infection with the Zika virus (ZIKV) poses a threat to human health. An improved understanding of host Toll-like receptor response, disease onset, and viral clearance in vivo vitro may lead development therapeutic or prophylactic interventions against infections. Currently, no clinically approved ZIKV vaccine is available, highlighting need for its development. In this study, we discuss progress vaccine, including advances use agonists as adjuvants enhance efficacy.

Language: Английский

Citations

0
Envelope Protein-Targeting Zika Virus Entry Inhibitors DOI Open Access
Abhijeet Roy, Qian Liu, Yang Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9424 - 9424

Published: Aug. 30, 2024

Zika virus (ZIKV; family, Flaviviridae), which causes congenital syndrome, Guillain-Barré Syndrome, and other severe diseases, is transmitted mainly by mosquitoes; however, the can be through routes. Among three structural seven nonstructural proteins, surface envelope (E) protein of ZIKV plays a critical role in viral entry pathogenesis, making it key target for development effective inhibitors. This review article describes life cycle, genome, encoded proteins ZIKV, illustrates structure function E protein, summarizes protein-targeting inhibitors (with focus on those based natural products small molecules), highlights challenges that may potentially hinder infection. Overall, will provide useful guidance further safe potent targeting protein.

Language: Английский

Citations

1
Addition of nucleotide adjuvants enhances the immunogenicity of a recombinant subunit vaccine against the Zika virus in BALB/c mice DOI
Iris Valdés, Edith Suzarte, Laura Lazo

et al.

Vaccine, Journal Year: 2024, Volume and Issue: 42(25), P. 126213 - 126213

Published: Aug. 12, 2024

Language: Английский

Citations

0
Concurrent Transmission of Zika Virus During the 2023 Dengue Outbreak in Bangladesh DOI
Anamul Hasan, Md. Mobarok Hossain,

Md Fahad Zamil

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Abstract Background During the 2023-dengue outbreak in Bangladesh, a diagnostic evaluation study was conducted to investigate concurrent Zika virus (ZIKV) and dengue (DENV) transmission Dhaka 2023. Aims The explored simultaneously detect presence of ZIKV, DENV, and/or CHIKV while considering relevant clinical epidemiological risk factors, using real-time multiplex RT-PCR system. Following this, it planned sequence selected samples identify genetic variations ZIKV infections within population. Methods This designed as evaluation, where participants meeting inclusion criteria were prospectively recruited with written informed consent. A total 399 febrile individuals screened, 185 having fever onset 2 – 5 days, along one following features, e.g. headache, myalgia, arthralgia or bone pain, rash, nausea, vomiting, diarrhea 152 undergoing testing. Results Five ZIKV-positive cases identified, including DENV-ZIKV co-infection. Phylogenetic analysis revealed strains part Asian lineage, closely related Cambodian Chinese from 2019. All male, residing one-kilometer radius, no prior travel history, suggesting community-level transmission. Conclusion marks first identification city report ZIKV-DENV co-infection Bangladesh that highlights challenges posed by symptomatic similarities between other arboviruses underscores need for enhanced surveillance public health interventions mitigate spread impact dengue-endemic regions. Synopsis explores co-transmission during 2023 shedding light on important issues. While is typically mild illness most people, can have serious neurological consequences, such microcephaly infants. Dengue, another mosquito-borne common tropical regions like affects significant portion research stands out because recorded instance Zika-Dengue country. discovery crucial both local global communities, challenge managing outbreaks similar viruses at same time, complicating diagnosis treatment. calls stronger better measures manage these viruses, particularly densely populated areas illnesses rapidly. work focuses importance raising awareness enhancing disease management practices reduce risks infections. overlap symptoms potentially outcomes vulnerable groups, pregnant women newborns, make understanding Zika’s critical. These insights guide future efforts vaccine development community level.

Language: Английский

Citations

0