Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(32)

Published: July 29, 2024

Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for compensation has long been thought to be critical in vertebrates. However, this was questioned by findings unequal mRNA abundance measurements monotreme mammals birds. Here, we demonstrate unbalanced levels X genes platypus males females a correlation differential loading histone modifications. We also observed transcripts Z chicken. Surprisingly, however, found that protein ratios were 1:1 the both species, indicating post-transcriptional layer compensation. conclude chromosome output is maintained chicken (and perhaps many other non therian vertebrates) via combination transcriptional control, consistent importance

Language: Английский

MAYEXis an old long noncoding RNA recruited for X chromosome dosage compensation in a reptile

Science, Journal Year: 2024, Volume and Issue: 385(6715), P. 1347 - 1354

Published: Sept. 19, 2024

Long noncoding RNAs (lncRNAs) are essential regulatory elements of sex chromosomes that act to equalize gene expression levels between males and females.

Language: Английский