Recently Delisted Songbird Harbors Extensive Genomic Evidence of Inbreeding, Potentially Complicating Future Recovery DOI Creative Commons
Anna Calderon, Andrew W. Wood, Zachary A. Szpiech

et al.

Evolutionary Applications, Journal Year: 2024, Volume and Issue: 17(12)

Published: Dec. 1, 2024

ABSTRACT The Kirtland's warbler ( Setophaga kirtlandii ) is a rare migratory passerine species and habitat specialist of the North American Jack Pine Forests. Their near extinction in 1970s classified them as endangered protected under Endangered Species Act 1973. After decades intense conservation management, their population size recovered, they were delisted from federal protection 2019. We explore genomic consequences this harsh bottleneck recovery by comparing architecture two closely related whose sizes have remained large stable, Hooded Warblers citrina Redstarts ruticilla ). used whole‐genome sequencing to characterize distribution runs homozygosity deleterious genetic variation. find evidence that warblers exhibit patterns consistent with recent inbreeding. Our results also show carry an excess proportion variation, which could complicate management for conservation‐reliant species. This analysis provides genetically informed perspective should be thoroughly considered when delisting other protections. Through increasing accessibility genome technology, it will more feasible monitor landscape recovering populations ensure long‐term survival independent intervention.

Language: Английский

The Maintenance of Deleterious Variation in Wild Chinese Rhesus Macaques DOI Creative Commons
Camille Steux, Zachary A. Szpiech

Genome Biology and Evolution, Journal Year: 2024, Volume and Issue: 16(6)

Published: May 24, 2024

Understanding how deleterious variation is shaped and maintained in natural populations important conservation evolutionary biology, as decreased fitness caused by these mutations can potentially lead to an increase extinction risk. It known that demographic processes influence patterns. For example, population bottlenecks inbreeding the probability of inheriting identical-by-descent haplotypes from a recent common ancestor, creating long tracts homozygous genotypes called runs homozygosity (ROH), which have been associated with accumulation mildly homozygotes. Counterintuitively, positive selection also maintain variants through genetic hitchhiking. Here, we analyze whole genomes 79 wild Chinese rhesus macaques across five subspecies characterize patterns respect ROH signals selection. We show fraction homozygotes occurring significantly higher for than tolerated ones, whereas this trend not observed short medium ROH. This confirms inbreeding, generating homozygosity, main driver high burden alleles macaque populations. Furthermore, evidence LOF are being purged. Next, identify seven at frequency regions putatively under near genes involved olfaction other processes. Our results shed light on shape distribution nonhuman primates.

Language: Английский

Citations

5
The Inbreeding Paradox: Is Inbreeding Avoidance Inevitable? - A Case Study of Moose (Alces alces) in the Northeast China DOI Creative Commons

Lu Jin,

Ning Zhang, Hairong Du

et al.

Global Ecology and Conservation, Journal Year: 2025, Volume and Issue: unknown, P. e03513 - e03513

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Maintenance of Deleterious Variation in Wild Chinese Rhesus Macaques DOI Creative Commons
Camille Steux, Zachary A. Szpiech

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 6, 2023

Understanding how deleterious variation is shaped and maintained in natural populations important conservation evolutionary biology, as decreased fitness caused by these mutations can potentially lead to an increase extinction risk. It known that demographic processes influence patterns. For example, population bottlenecks inbreeding the probability of inheriting identical-by-descent haplotypes from a recent common ancestor, creating long tracts homozygous genotypes called runs homozygosity (ROH), which have been associated with accumulation mildly homozygotes. Counter intuitively, positive selection also maintain variants through genetic hitchhiking. Here we analyze whole genomes 79 wild Chinese rhesus macaques across five subspecies characterize patterns respect ROH signals selection. We show fraction homozygotes occurring significantly higher for than tolerated ones, whereas this trend not observed short medium ROH. This confirms inbreeding, generating homozygosity, main driver high burden alleles macaque populations. Furthermore, evidence LOF are being purged. Next, identify 7 at frequency regions putatively under near genes involved olfaction other processes. Our results shed light on shape distribution non-human primates.

Language: Английский

Citations

2
Recently Delisted Songbird Harbors Extensive Genomic Evidence of Inbreeding, Potentially Complicating Future Recovery DOI Creative Commons
Anna Calderon, Andrew W. Wood, Zachary A. Szpiech

et al.

Evolutionary Applications, Journal Year: 2024, Volume and Issue: 17(12)

Published: Dec. 1, 2024

ABSTRACT The Kirtland's warbler ( Setophaga kirtlandii ) is a rare migratory passerine species and habitat specialist of the North American Jack Pine Forests. Their near extinction in 1970s classified them as endangered protected under Endangered Species Act 1973. After decades intense conservation management, their population size recovered, they were delisted from federal protection 2019. We explore genomic consequences this harsh bottleneck recovery by comparing architecture two closely related whose sizes have remained large stable, Hooded Warblers citrina Redstarts ruticilla ). used whole‐genome sequencing to characterize distribution runs homozygosity deleterious genetic variation. find evidence that warblers exhibit patterns consistent with recent inbreeding. Our results also show carry an excess proportion variation, which could complicate management for conservation‐reliant species. This analysis provides genetically informed perspective should be thoroughly considered when delisting other protections. Through increasing accessibility genome technology, it will more feasible monitor landscape recovering populations ensure long‐term survival independent intervention.

Language: Английский

Citations

0