Infertility and cortisol: a systematic review DOI Creative Commons

Bheena Vyshali Karunyam,

Abdul Karim, Isa Naina Mohamed

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: June 29, 2023

Stress and infertility form a complex relationship. In line with this, various stress-related biological markers have been investigated in infertility.This systematic review was performed using PRISMA guidelines (i) to report whether cortisol is highly present infertile patients compared fertile control; (ii) there any significant difference the level subjects that conceive those didn't at end of assisted reproduction treatments. Original articles involving human (male female) as were extracted from four electronic databases, including list references published papers. Sixteen original full-length male (4), female (11), both genders (1) included.Findings studies between indicate Male: three reported elevated one found no difference; Female: increased difference. Findings measured conceived study conceived, whereas two unable conceive. Five groups.In we only included value prior stimulation or IVF treatment during natural spontaneous cycles, despite are still variations sampling period, assessment techniques patients' characteristics. Hence, present, conclude significantly patients. We warrant future standardize time sample collection other limitations addressed negate unwanted influencing factors.

Language: Английский

Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

204
Mitochondria: Their relevance during oocyte ageing DOI Creative Commons
Jiska van der Reest, Gustavo Nardini Cecchino, Marcia C. Haigis

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 70, P. 101378 - 101378

Published: June 4, 2021

The oocyte is recognised as the largest cell in mammalian species and other multicellular organisms. Mitochondria represent a high proportion of cytoplasm oocytes mitochondrial architecture different than somatic cells, characterised by rounder appearance fragmented network. Although number mitochondria per higher any cell, their activity decrease with advancing age. integrate numerous processes essential for cellular function, such metabolic related to energy production, biosynthesis, waste removal, well Ca2+ signalling reactive oxygen (ROS) homeostasis. Further, are responsible adaptation types stressors oxidative stress or DNA damage. When these outstrip adaptive capacity restore homeostasis, it leads dysfunction. Decades studies indicate that function multifaceted, which reflected oocyte, where support during maturation, fertilization, early embryonic development. Dysregulation has been consistently reported ageing age-related diseases. In this review, we describe functions bioenergetic powerhouses signal transducers oocytes, how dysfunction contributes reproductive ageing, whether could be targeted promote rejuvenation.

Language: Английский

Citations

153
Hormones and Aging: An Endocrine Society Scientific Statement DOI Open Access
Anne Rentoumis Cappola, Richard J. Auchus, Ghada El‐Hajj Fuleihan

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 108(8), P. 1835 - 1874

Published: June 16, 2023

Multiple changes occur across various endocrine systems as an individual ages. The understanding of the factors that cause age-related and how they should be managed clinically is evolving. This statement reviews current state research in growth hormone, adrenal, ovarian, testicular, thyroid axes, well osteoporosis, vitamin D deficiency, type 2 diabetes, water metabolism, with a specific focus on older individuals. Each section describes natural history observational data individuals, available therapies, clinical trial efficacy safety key points, scientific gaps. goal this to inform future refines prevention treatment strategies age-associated conditions, improving health

Language: Английский

Citations

48
Geroscience and pathology: a new frontier in understanding age-related diseases DOI Creative Commons
Mónika Fekete, Dávid Major,

Ágnes Fehér

et al.

Pathology & Oncology Research, Journal Year: 2024, Volume and Issue: 30

Published: Feb. 23, 2024

Geroscience, a burgeoning discipline at the intersection of aging and disease, aims to unravel intricate relationship between process pathogenesis age-related diseases. This paper explores pivotal role played by geroscience in reshaping our understanding pathology, with particular focus on These diseases, spanning cardiovascular cerebrovascular disorders, malignancies, neurodegenerative conditions, significantly contribute morbidity mortality older individuals. We delve into fundamental cellular molecular mechanisms underpinning aging, including mitochondrial dysfunction senescence, elucidate their profound implications for various Emphasis is placed importance assessing key biomarkers biological age within realm pathology. also scrutinize interplay senescence cancer biology as central area focus, underscoring its paramount significance contemporary pathological research. Moreover, we shed light integration anti-aging interventions that target processes, such senolytics, mitochondria-targeted treatments, influence epigenetic regulation domain pathology In conclusion, concepts research heralds transformative paradigm shift disease promises breakthroughs prevention treatment.

Language: Английский

Citations

30
Aging conundrum: A perspective for ovarian aging DOI Creative Commons
Jiachen Wu,

Yang Liu,

Yinhua Song

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 19, 2022

Progressive loss of physiological integrity and accumulation degenerative changes leading to functional impairment increased susceptibility diseases are the main features aging. The ovary, key organ that maintains female reproductive endocrine function, enters aging earlier faster than other organs has attracted extensive attention from society. Ovarian is mainly characterized by progressive decline in number quality oocytes, regulatory mechanisms which have yet be systematically elucidated. This review discusses hallmarks further highlight characteristics ovarian attempt explore its clinical symptoms underlying mechanisms. Finally, intervention strategies related elaborated, especially potential role stem cells cryopreservation embryos, or tissue delay

Language: Английский

Citations

43
Unraveling female reproductive senescence to enhance healthy longevity DOI
Lu Dong, Daniel Boon Loong Teh, Brian K. Kennedy

et al.

Cell Research, Journal Year: 2023, Volume and Issue: 33(1), P. 11 - 29

Published: Jan. 2, 2023

Language: Английский

Citations

37
Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives DOI Creative Commons

Saghi Hakimi Naeini,

Laleh Mavaddatiyan,

Zahra Rashid Kalkhoran

et al.

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 175, P. 112154 - 112154

Published: March 20, 2023

Aging is a natural process that determined by functional decline in cells and tissues as organisms are growing old, resulting an increase at risk of disease death. To this end, many efforts have been made to control aging lifespan healthspan. These led the discovery several anti-aging drugs compounds such rapamycin metformin. Recently, alpha-ketoglutarate (AKG) has introduced potential metabolite can functions organisms, thereby increases longevity improves Unlike other synthetic drugs, AKG one metabolites tricarboxylic acid (TCA) cycle, also known Krebs synthesized body. It plays crucial role cell energy metabolism, amino acid/protein synthesis, epigenetic regulation, stemness differentiation, fertility reproductive health, cancer behaviors. exerts its effects through different mechanisms inhibiting mTOR ATP-synthase, modulating DNA histone demethylation reducing ROS formation. Herein, we summarize recent findings AKG-related healthspan studies discuss associated molecular involved increasing longevity, improving reproduction, stem behavior. We promises limitations for delaying applications.

Language: Английский

Citations

32
Single‐Cell Atlas of Human Ovaries Reveals The Role Of The Pyroptotic Macrophage in Ovarian Aging DOI Creative Commons
Chuanchuan Zhou, Qi Guo,

Jiayu Lin

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(4)

Published: Nov. 30, 2023

Abstract Female fecundity declines in a nonlinear manner with age during the reproductive years, even as ovulatory cycles continue, which reduces female fertility, disrupts metabolic homeostasis, and eventually induces various chronic diseases. Despite this, aging‐related cellular molecular changes human ovaries that occur these years have not been elucidated. Here, single‐cell RNA sequencing (scRNA‐seq) of is performed from different childbearing ages reveals activation pyroptosis pathway increased age, mainly macrophages. The enrichment pyroptotic macrophages leads to switch tissue‐resident macrophage (TRM)‐involve immunoregulatory microenvironment young monocyte‐derived (MDM)‐involved proinflammatory middle‐aged ovaries. This remolded ovarian immuno‐microenvironment further promotes stromal cell senescence accelerated decline. hypothesis validated series animal experiments using GSDMD‐KO mice. In conclusion, work expands current understanding aging process by illustrating macrophage‐involved immune mechanism, has important implications for development novel strategies delay promote health.

Language: Английский

Citations

28
Hydrogen Sulfide (H2S): As a Potent Modulator and Therapeutic Prodrug in Cancer DOI
Pawan Faris, Sharon Negri,

Delia Faris

et al.

Current Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 30(40), P. 4506 - 4532

Published: Jan. 27, 2023

Hydrogen sulfide (H2S) is an endogenous gaseous molecule present in all living organisms that has been traditionally studied for its toxicity. Interestingly, increased understanding of H2S effects organ physiology recently shown relevance as a signalling molecule, with potentially important implications variety clinical disorders, including cancer. primarily produced mammalian cells under various enzymatic pathways are target intense research biological mechanisms, and therapeutic H2S. Herein, we describe the physiological biochemical properties H2S, leading to production catabolic routes. In addition, discuss role currently known H2S-releasing agents, or donors, their potential tools. Then illustrate mechanisms support pleiotropic particular focus on persulfhydration, which plays key H2S-mediating pathways. We then address paradoxical played by tumour biology exploiting levels novel cancer biomarkers diagnostic Finally, most recent preclinical applications focused assessing anti-cancer impact common compounds. While evidence favour alternative therapy field translational medicine yet be clearly provided, application emerging potent anticancer trails.

Language: Английский

Citations

15
Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway DOI Creative Commons
Hanwen Liu, Chunyan Jiang,

Boya La

et al.

Stem Cell Research & Therapy, Journal Year: 2021, Volume and Issue: 12(1)

Published: June 2, 2021

Abstract Background Age-related diminished ovarian reserve (AR-DOR) reduced the quality of oocytes, resulting in decreased female fertility. Aging is tightly related to abnormal distribution and function mitochondria, while mitophagy a major process maintain normal quantity mitochondria cells, especially oocytes which containing large number meet demand energy production during oocyte maturation subsequent embryonic development. Ampk/FoxO3a signaling crucial regulation mitophagy. It reported mesenchymal stem cells (MSCs) can improve function. Here we aim explore if human amnion-derived (hAMSCs) are effective improving AR-DOR mice whether involved. Methods The model were established by 32-week-old with 3–8 litters, significantly low serum sex hormone levels follicle counts. old divided into 5 treatment groups: saline (NS, control), 1% albumin (HSA, resolver), dose (LD, 5.0 × 10 6 cells/kg), middle (MD, 7.5 high (HD, 10.0 cells/kg). prepared hAMSCs injected through tail vein. Serum level, counts, fertilization rate, gestation little size, apoptosis granulosa stromal expression level Sod2, Ampk, ratio phosphorylated FoxO3a total ovaries examined. Results Our results show that after hAMSC transplantation, was improved, meanwhile repressed, Ampk both increased, increased Sod2 also observed. Conclusion demonstrate transplantation via tail-injection pathway.

Language: Английский

Citations

32