Nutrients,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1725 - 1725
Published: May 31, 2024
The
global
population
is
on
a
trajectory
of
continuous
growth,
with
estimates
projecting
an
increase
from
7.7
billion
in
2019
to
approximately
9.7
by
2050.
Longevity
also
expected
rise
rapidly,
advancements
healthcare
contributing
increased
life
expectancies
and
the
maximum
lifespan.
aging
process
accompanied
different
changes,
often
leading
decline
daily
activities
susceptibility
disease.
Age-related
changes
can
cause
cellular
damage
subsequent
death.
Oxidative
stress
inflammation
play
significant
roles
this
molecular
mitochondrial
dysfunction.
Active
has
been
associated
improved
quality
reduced
risk
morbidity
premature
mortality.
In
context,
Mediterranean
diet
emerged
as
promising
approach
promoting
healthy
sustainability.
phytochemical
compounds
within
have
linked
lower
developing
cardiovascular
disease,
type
2
diabetes,
obesity,
cancer
neurodegenerative
diseases.
findings
peer-reviewed
articles
regarding
use
sustainable
dietary
pattern
written
Portuguese,
Spanish
or
English
were
included
narrative
literature
review.
This
pattern’s
emphasis
consumption
fresh
local
food
aligns
both
health
environmental
sustainability
goals.
work
provides
comprehensive
review
benefits
its
components
highlights
importance
approach.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: June 8, 2023
Abstract
Aging
is
characterized
by
systemic
chronic
inflammation,
which
accompanied
cellular
senescence,
immunosenescence,
organ
dysfunction,
and
age-related
diseases.
Given
the
multidimensional
complexity
of
aging,
there
an
urgent
need
for
a
systematic
organization
inflammaging
through
dimensionality
reduction.
Factors
secreted
senescent
cells,
known
as
senescence-associated
secretory
phenotype
(SASP),
promote
inflammation
can
induce
senescence
in
normal
cells.
At
same
time,
accelerates
immune
resulting
weakened
function
inability
to
clear
cells
inflammatory
factors,
creates
vicious
cycle
senescence.
Persistently
elevated
levels
organs
such
bone
marrow,
liver,
lungs
cannot
be
eliminated
leading
damage
aging-related
Therefore,
has
been
recognized
endogenous
factor
elimination
could
potential
strategy
anti-aging.
Here
we
discuss
at
molecular,
cellular,
organ,
disease
levels,
review
current
aging
models,
implications
cutting-edge
single
cell
technologies,
well
anti-aging
strategies.
Since
preventing
alleviating
diseases
improving
overall
quality
life
are
ultimate
goals
research,
our
highlights
critical
features
mechanisms
along
with
latest
developments
future
directions
providing
theoretical
foundation
novel
practical
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Feb. 5, 2024
Abstract
Cellular
senescence
represents
an
irreversible
state
of
cell-cycle
arrest
during
which
cells
secrete
senescence-associated
secretory
phenotypes,
including
inflammatory
factors
and
chemokines.
Additionally,
these
exhibit
apoptotic
resistance
phenotype.
serves
a
pivotal
role
not
only
in
embryonic
development,
tissue
regeneration,
tumor
suppression
but
also
the
pathogenesis
age-related
degenerative
diseases,
malignancies,
metabolic
kidney
diseases.
The
renal
tubular
epithelial
(RTEC)
constitutes
critical
cellular
event
progression
acute
injury
(AKI).
RTEC
inhibits
regeneration
repair
processes
and,
concurrently,
promotes
transition
AKI
to
chronic
disease
via
mechanisms
underlying
are
multifaceted
include
telomere
shortening
or
damage,
DNA
mitochondrial
autophagy
deficiency,
disorders,
endoplasmic
reticulum
stress,
epigenetic
regulation.
Strategies
aimed
at
inhibiting
senescence,
targeting
clearance
senescent
RTEC,
promoting
apoptosis
hold
promise
for
enhancing
prognosis
AKI.
This
review
primarily
focuses
on
characteristics
impact
intervening
AKI,
aiming
provide
foundation
understanding
providing
potentially
effective
approaches
treatment.
