Beyond the Hayflick limit: How microbes influence cellular aging

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102657 - 102657

Published: Jan. 7, 2025

Language: Английский

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The Impact of Stress and Social Determinants on Diet in Cardiovascular Prevention in Young Women

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1044 - 1044

Published: April 3, 2024

The prevention of cardiovascular diseases is a fundamental pillar for reducing morbidity and mortality caused by non-communicable diseases. Social determinants, such as socioeconomic status, education, neighborhood, physical environment, employment, social support networks, access to health care, play crucial role in influencing outcomes inequities within populations. determinants stress women are interconnected factors that can significantly impact women’s well-being. Pregnancy good time engage young introduce them beneficial behaviors, adopting essential life skills, especially diet, learning management techniques. Stress influences more likely unhealthy eating behaviors emotional or coping with food. Strong action needed improve lifestyle starting at age considering this lays the foundation lower risk adults elderly. objective review examine primary healthy women, focusing particularly on unresolved issues influence well correlation stressors their diet.

Language: Английский

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Lifestyle factors and metabolomic aging biomarkers: Meta-analysis of cross-sectional and longitudinal associations in three prospective cohorts

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111958 - 111958

Published: June 29, 2024

Language: Английский

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Cross-sectional associations of epigenetic clocks with intrinsic capacity and functional ability in older adults with frailty and cognitive impairment: the COGFRAIL study

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Language: Английский

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Associations of various healthy dietary patterns with biological age acceleration and the mediating role of gut microbiota: results from the China Multi-Ethnic Cohort study

British Journal Of Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 31

Published: Nov. 4, 2024

Abstract To investigate the associations between dietary patterns and biological aging, identify most recommended pattern for coping with aging explore potential mediating role of gut microbiota in less-developed ethnic minority regions (LEMRs). This prospective cohort study included 8288 participants aged 30-79 years from China Multi-Ethnic Cohort (CMEC). Anthropometric measurements clinical biomarkers were utilized to construct age based on Klemera Doubal’s method (KDM-BA) KDM-BA acceleration (KDM-AA). Dietary information was obtained through baseline food frequency questionnaire (FFQ). Six constructed: plant-based diet index (PDI), healthful (hPDI), unhealthful (uPDI), healthy score (HDS), Approaches Stop Hypertension (DASH), alternative Mediterranean diets (aMED). Follow-up adjusted analysis employed assess KDM-AA. Additionally, quantile G-computation evaluate significant beneficial harmful groups. In subsample 764 data 16S rRNA gene sequencing, we used causal mediation model The results showed that all associated Transitioning non-compliance compliance, DASH exhibited strongest negative association KDM-AA [ β = -0.91, 95%CI (-1.19, -0.63)]. component analyses revealed tea soybean products groups, while salt, preserved vegetables, red processed meats identified as major analysis, decreased abundance Synergistetes phylum Pyramidobacter genus possibly mediated (5.61%-9.19%). Overall, patterns, especially DASH, are negatively LEMRs. may mediate aging. Developing appropriate strategies promote

Language: Английский

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Physical activity and DNA methylation–based markers of ageing in 6208 middle-aged and older Australians: cross-sectional and longitudinal analyses

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Epigenetic age quantifies biological using DNA methylation information and is a potential pathway by which physical activity benefits general health. We aimed to assess the cross-sectional longitudinal associations between epigenetic in middle-aged older Australians. Blood data for 6208 participants (40% female) Melbourne Collaborative Cohort Study (MCCS) were available at baseline (1990-1994, mean age, 59 years) and, of those, 1009 follow-up (2003-2007, 69 years). Physical measurements (weighted scores total MET hours per week follow-up) calculated from self-reported questionnaire data. Five blood methylation-based markers ageing (PCGrimAge, PCPhenoAge, bAge, DNAmFitAge, DunedinPACE) four fitness-related (DNAmGaitspeed, DNAmGripmax, DNAmVO2max, DNAmFEV1) adjusted age. Linear regression was used examine Effect modification sex, BMI assessed. At baseline, standard deviation (SD) increment associated with 0.03-SD (DNAmFitAge, 95%CI = 0.01, 0.06, P 0.02) 0.07-SD (bAge, 0.04, 0.09, 2 × 10

Language: Английский

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Self-rated health, epigenetic ageing, and long-term mortality in older Australians

GeroScience, Journal Year: 2024, Volume and Issue: 46(6), P. 5505 - 5515

Published: May 25, 2024

Self-rated health (SRH) is a subjective indicator of overall based on single questionnaire item. Previous evidence found that it strong predictor mortality, although the underlying mechanism poorly understood. Epigenetic age an objective, emerging biomarker health, estimated using DNA methylation data at hundreds sites across genome. This study aimed to assess overlap and interaction between SRH epigenetic ageing in predicting mortality risk. We used from 1059 participants Melbourne Collaborative Cohort Study (mean age: 69 years) calculate three age-adjusted measures ageing: GrimAge, PhenoAge, DunedinPACE. was assessed five-category item ("excellent, very good, fair, poor"). Cox models were associations SRH, ageing, their interaction, with all-cause over up 17 years follow-up (N

Language: Английский

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Stress and eating behaviors in young subjects can influence early cardiovascular prevention

Cadernos de Saúde Pública, Journal Year: 2024, Volume and Issue: 40(3)

Published: Jan. 1, 2024

Dear Editors,We have read with great interest the article Adherence to Mediterranean Diet and Depression, Anxiety, Stress Symptoms in Chilean University Students: A Cross-Sectional Study by Morales et al. 1 , consider it significant field of early cardiovascular prevention.The authors found that adherence diet consumption fruit, vegetables, nuts, avocado, fish, seafood are associated a lower likelihood depression university students.Regarding findings reported paper, we would like make following contribution discussion.Atherosclerosis -which is basis diseases -is long process begins childhood main cause events adulthood old age 2,3 .Unfortunately, known there lack awareness on relevance intervention, especially among young people women 4,5 .Stress exert notable influence dietary behaviors, manifesting various ways differ individuals.The relation between stress complex, its effects can be both immediate or long-lasting.Common patterns emotional eating cravings 6,7,8 .Emotional coping mechanism often involves consuming foods provide comfort, high content calories, sugar, unhealthy fats.Furthermore, induce specific cravings, typically for sugar-, fat-, salt-rich .Under stress, individuals may opt convenience quick obtain but nutritional value, contributing habits.Stress also disrupt normal habits, leading either overeating undereating.Both hold implications overall health 7,8 .Obesity induces an inflammatory state characterized increase leptin levels, pro-inflammatory adipokine, decreased levels adiponectin, anti-inflammatory been 7,8,9,10 .Inflammation has strongly development atherosclerosis.Regular physical activity helps fight against obesity inflammation.An additional beneficial effect regular managing suggested 11 .The offers many benefits 12,13 .Undoubtedly, fruit vegetable intake good index assessing and, as known, extremely variable shows differences sexes 14,15,16 .Ensuring adequate vitamins incorporating

Language: Английский

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Suboptimal dietary patterns are associated with accelerated biological aging in young adulthood: a twin study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

ABSTRACT Background & aims Suboptimal diets increase morbidity and mortality risk. Epigenetic clocks are algorithms that can assess health lifespan, even at a young age, before clinical manifestations of diseases. We investigated the association between dietary patterns biological aging in adult twins. Methods The data were drawn from population-based FinnTwin12 study consisted twins aged 21–25 years (n=826). Food beverage intakes assessed using food frequency questionnaire. Biological was estimated epigenetic GrimAge DunedinPACE. Latent class analysis used to identify patterns. linear regression modeling individual level, followed by within–twin pair analyses account for genetic liabilities shared familial confounders. Results Six identified: 1) High fast food, low fruits vegetables (F&V), 2) Plant-based, 3) Health-conscious, 4) Western with infrequent fish, 5) regular 6) Balanced average. At acceleration slower Balanced-average compared F&V, faster fish pattern average, regardless sex, nonalcoholic energy intake, smoking, alcohol consumption. After further adjustment BMI sports participation, strengths associations modestly decreased; however, difference F&V remained significant. pace (DunedinPACE) Plant-based after alcohol. effect sizes attenuated reached non-significant level when participation added model. Most replicated within-pair among all twin pairs dizygotic pairs, but tended be smaller monozygotic pairs. This suggests genetics, not environment, may partially explain observed diet aging. Conclusion Diets high processed red meat, sugar-sweetened beverages associated accelerated adulthood. clustering lifestyle factors confounders should considered interpreting findings.

Language: Английский

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Slower pace of epigenetic aging and lower inflammatory indicators in women following a nutrient-dense, plant-rich diet compared to the standard American diet

Current Developments in Nutrition, Journal Year: 2024, Volume and Issue: 8(12), P. 104497 - 104497

Published: Oct. 30, 2024

Language: Английский

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