Serum Exosomal hsa-miR-142-5p, hsa-miR-1908-5p, and hsa-miR-450b-5p as Candidate Biomarkers for Recurrent Depressive Disorder Diagnosis and ECT Treatment Response: A Preliminary Investigation

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111345 - 111345

Published: April 1, 2025

Language: Английский

A comprehensive study of genetic regulation and disease associations of plasma circulatory microRNAs using population-level data

Genome biology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 21, 2024

Abstract Background MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Perturbations in plasma miRNA levels known to impact disease risk and have potential as biomarkers. Exploring the genetic regulation of miRNAs may yield new insights into their important role governing expression mechanisms. Results We present genome-wide association studies 2083 circulating 2178 participants Rotterdam Study identify miRNA-expression quantitative trait loci (miR-eQTLs). 3292 associations between 1289 SNPs 63 miRNAs, which 65% replicated two independent cohorts. demonstrate miR-eQTLs co-localise with expression, protein, metabolite-QTLs, help identifying miRNA-regulated pathways. investigate consequences alteration on a wide range clinical conditions phenome-wide Mendelian randomisation using UK Biobank data ( N = 423,419), revealing pleiotropic causal effects several various conditions. In analysis, we find protective effect miR-1908-5p benign colon neoplasm show this is its host FADS1 ). Conclusions This study enriches our understanding architecture explores signatures across The integration population-based genomics, other omics layers, presents opportunities unravel significance provides tools for novel miRNA-based therapeutic target discovery.

Language: Английский

A scoping review of statistical methods to investigate colocalization between genetic associations and microRNA expression in osteoarthritis

Osteoarthritis and Cartilage Open, Journal Year: 2024, Volume and Issue: 6(4), P. 100540 - 100540

Published: Nov. 8, 2024

Language: Английский