A Call for New Theories on the Pathogenesis and Pathophysiology of Endometriosis

Journal of Minimally Invasive Gynecology, Journal Year: 2024, Volume and Issue: 31(5), P. 371 - 377

Published: Feb. 15, 2024

This group was formed out of the conviction that endometriosis research has not progressed at a pace in proportion to disease severity and negative impact on women's quality life. Furthermore, advancement our understanding this condition requires quantum shift based new theories pathogenesis. With conviction, international calls for may improve condition, leading optimized management or even prevention. To facilitate this, dedicated website serving as repository where all proposed can be reviewed critiqued by peers will created.

Language: Английский

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Endometriosis-Associated Ovarian Cancer: From Molecular Pathologies to Clinical Relevance

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4306 - 4306

Published: April 13, 2024

Endometriosis is a chronic condition affecting reproductive-aged women, characterized by the growth of ectopic endometrial tissue. Despite being benign, endometriosis associated with an increased risk certain cancers, including endometriosis-associated ovarian cancer (EAOC). Ovarian rare, but more common in women endometriosis, particularly endometrioid and clear-cell carcinomas. Factors such as hormonal imbalance, reproductive history, environmental exposures, genetic predisposition contribute to malignant transformation endometriosis. Thus, understanding potential factors causing malignancy crucial. Over past few decades, various mutations, microRNAs, well tumor microenvironmental have been identified, impacting pathways like PI3K/AKT/mTOR, DNA repair mechanisms, oxidative stress, inflammation. this review aims summarize molecular studies involved EAOC pathogenesis therapeutic targets. However, further research needed better understand driving development, target susceptibility endometriotic lesions progression, identify effective strategies.

Language: Английский

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Adenomyosis and Adolescence: A Challenging Diagnosis and Complex Management

Diagnostics, Journal Year: 2024, Volume and Issue: 14(21), P. 2344 - 2344

Published: Oct. 22, 2024

Adenomyosis is a chronic, hormone-related disease characterized by the presence of endometrial glands and stroma within myometrium. This condition can manifest in various features, focal or diffuse adenomyosis as an adenomyoma, it may involve different uterine walls (posterior, anterior, and/or lateral walls). The also be classified into degrees, mild, moderate severe, which associated with more intense symptoms, although this correlation not always directly proportional. In fact, asymptomatic about third cases significantly impact patients’ quality life through painful such dysmenorrhea dyspareunia, abnormal bleeding—particularly heavy menstrual bleeding—and potential effects on fertility. Historically, has been considered primarily affecting premenopausal women over age 40, often multiparous, because diagnosis was traditionally based surgical reports from hysterectomies performed after completion reproductive desire. Data adolescent patients remain limited. However, recent years, advancements noninvasive diagnostic tools increased awareness pathology have enabled earlier diagnoses. appears to early onset during adolescence, tendency progress terms extent severity time. coexists endometriosis, onset. Therefore, important, when diagnosing adenomyosis, screen for concomitant especially deep endometriosis posterior compartment. aim narrative review investigate prevalence types degrees younger patients, assess describe most appropriate procedures effective therapeutic management follow-up, goal improving these young women.

Language: Английский

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Association Between the Oxidative Balance Score and Endometriosis: A Population-Based Study

International Journal of Women s Health, Journal Year: 2024, Volume and Issue: Volume 16, P. 1293 - 1301

Published: July 1, 2024

Purpose: To investigate the association between oxidative balance score (OBS) and endometriosis. Methods: This cross-sectional study used four cycles of National Health Nutrition Examination Survey (NHANES) (1999– 2000, 2001– 2002, 2003– 2004, 2005– 2006). OBS involved 16 dietary nutrients 4 lifestyle factors, including 5 pro-oxidants 15 anti-oxidants. According to weighted quartiles, was divided into categories: < 12.54, 12.54– 18.70, 18.71– 24.68, > 24.68. Endometriosis diagnosed based on a question from reproductive health questionnaire. Weighted multivariate logistic analysis Subgroup performed menstrual regularity female hormone use. Results: A total 5095 women were included, with 1140 (22.37%), 1232 (24.18%), 1224 (24.02%), 1499 (29.42%) in 24.68 categories, respectively. After adjusting age, race, family poverty-to-income ratio (PIR), education level, uterine fibroids, regularity, oophorectomy, use, hypertension, dyslipidemia, steroid drug, high (> 24.68) found be associated lower odds endometriosis [odds (OR) = 0.70, 95% confidence interval (CI): 0.50– 0.97, P 0.033] compared low (< 12.54). The similar result also irregular menstruation (OR 0.58, CI: 0.37– 0.91, 0.020) use 0.71, 0.52– 0.98, 0.037). Conclusion: endometriosis, especially Keywords: Oxidative score, menstruation, hormones, NHANES

Language: Английский

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A review of phase II and III drugs for the treatment and management of endometriosis

Expert Opinion on Emerging Drugs, Journal Year: 2023, Volume and Issue: 28(4), P. 333 - 351

Published: Oct. 2, 2023

Introduction Endometriosis is an estrogen-dependent disease that gives rise to pelvic pain and infertility. Although estroprogestins progestins currently stand as the first-line treatments for this condition, demonstrating efficacy in two-thirds of patients, a significant portion individuals experience only partial relief or symptom recurrence following cessation these therapies. The coexistence superficial, deep endometriosis, ovarian endometriomas, three distinct phenotypes with unique pathogenetic molecular characteristics, may elucidate current heterogeneous biological response available therapy.

Language: Английский

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Role of Salivary MicroRNA as a Marker of Progesterone Resistance in Endometriosis: Preliminary Results from a Single-Institution Experience

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 493 - 493

Published: March 27, 2025

This feasibility study explores the potential of salivary microRNAs (miRNAs) as non-invasive biomarkers for diagnosing endometriosis and assessing treatment response. Almost one-third patients with do not respond to standard progestin due various mechanisms progesterone resistance. MiRNAs, recognized their stability in body fluids role gene regulation, may offer new diagnostic prognostic opportunities they are involved pathogenic pathways We sequenced miRNAs three cohorts patients: control women without who responded did treatment. aims identify differential miRNA expression profiles associated therapeutic response dienogest. The preliminary results demonstrate sequencing from saliva reveal distinct between responders, non-responders, controls. Key miRNAs, including mir-3168, mir-200a family, mir-93-5p, emerged biomarkers, showing significant linked both presence Further validation these findings larger could pave way miRNA-based tools, potentially reducing delays personalizing approaches patients, also target therapies.

Language: Английский

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Endometrial thickness and its diagnostic utility in postmenopausal women: A retrospective analysis of ultrasound and histopathological findings

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 101509 - 101509

Published: April 21, 2025

Language: Английский

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Twenty-five years of research in endometriosis

Reproductive BioMedicine Online, Journal Year: 2025, Volume and Issue: 50(4), P. 104830 - 104830

Published: April 1, 2025

Language: Английский

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Drug Screening of Primary Human Endometriotic Cells Based on Micro‐Encapsulating Microfluidic Chip

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Endometriosis (EMs), a significant global health issue, characterized by unclear pathogenesis, nonspecific symptoms, and poor treatment outcomes. The organ‐on‐chip technology has achieved great advances in disease modeling, yet its potential EMs‐related research remains largely untapped. Herein, microfluidic chip platform that integrates primary cell‐laden microcapsules for personalized drug evaluation. Specifically, human ectopic endometrial stromal cells (hESCs) within featuring biocompatible carboxymethyl cellulose (CMC) core stable alginate (ALG) shell using precise electrospray are encapsulated. These integrated into with branched gradient generator multiple cell‐culture chambers, enabling tailored high‐throughput screening. By exposing hESCs‐microcapsules derived from of distinct patient individuals to various drugs on‐chip, inter‐individual variability was revealed, strong correlation clinical This unique combination patient‐specific 3D microenvironments dynamic control represents paradigm shift EMs research. Further integrating omics techniques, capability exploring promising is showcased. results reveal the could deliver dependable screening outcomes, thereby benefiting both scientific inquiries therapies.

Language: Английский

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Artificial Intelligence in the Management of Women with Endometriosis and Adenomyosis: Can Machines Ever Be Worse than Humans?

Published: March 18, 2024

Artificial intelligence (AI) is experiencing advances and integration in all medical specializations, this creates excitement but also concerns. This narrative review aims at a critical assessment of the state art AI field endometriosis adenomyosis. By enabling automation, may speed up some routine tasks, decreasing gynecologists’ risk burnout, as well them to spend more time interacting with their patients, increasing efficiency patients’ perception being taken care of. Surgery benefit from AI, especially through its robotic surgery systems. improve detection anatomical structures enhance surgical outcomes by combining intra-operative findings pre-operative imaging. Not only, promises quality facilitating clinical research introduction decision support tools that can diagnostic predict treatment effectiveness side effects, reproductive prognosis cancer risk. However, concerns exist regarding fact good data used tool development compliance sharing guidelines are crucial. Also, professionals worried render certain specialists obsolete. said, likely become well-liked team member rather than usurper.

Language: Английский

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