Hyphae and Healthspan DOI Creative Commons
Patrick Chambers

Published: Aug. 6, 2024

Candida overgrowth (CO) can induce an avalanche of health problems. Its hyphal wall contains epitopes that trigger not only gluten type antibodies (celiac disease) but also a plethora mannan related targeting Gq coupled GPCRs. These latter disrupt autonomic receptors, inducing POTS, loss taste and smell, many other symptoms. auto-antibodies chemotactic cytokine receptors (CCRs) pain, psoriasis, alopecia areata, vitiligo maladies. They target T cells otherwise suppress latent viruses, e.g., EBV. Hyphae release candidalysin, toxin suppresses growth competing intestinal bacteria, triggers inflammasomes, causes hypercitrullination. Anti-citrullinated peptide (ACPAs) are produced. B exposed to hyper citrullination develop citrullinated receptors. ACPAs CCRs may jointly viral reactivation from infected cells. EBV, in virtually all humans now free circulate, is targeted by these same ACPAs. EBV nuclear material released antinuclear (ANAs) emerge. the histamine tryptase mast Tryptase have been tightly linked trifecta cell activation syndrome (MCAS), hypermobility spectrum disorder (HSD), POTS addition long Covid (LC) probably anti-phospholipid (APS). periodontitis. Bacteria generally considered be culprits, hyphae its biofilm facilitate their pathogenesis. Periodontitis with sentinel risk indicator for cancer, dementia, autoimmune disease, ASCVD chronic disease general. D3 tryptophan oppose invasive transition Candida, which responds releasing indoleamine dioxygenase degrades tryptophan. This altered metabolism characteristic these. Ultimately directly or indirectly involved gut dysbiosis, including periodontitis, detriment healthspan. The approach conceptual empirical.

Language: Английский

Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis DOI Creative Commons
Beiming Wang, Xiaoyin Bai,

Yingmai Yang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 11, 2025

Mounting evidence suggests that Parkinson's disease (PD) and inflammatory bowel (IBD) are closely associated becoming global health burdens. However, the causal relationships common pathogeneses between them uncertain. Furthermore, they uncurable. Thus, we aimed to identify novel therapeutic targets shared based on their pathophysiological mechanisms in gut–brain-axis (GBA). A meta-analysis bidirectional Mendelian randomization (MR) utilizing various datasets was performed estimate relationship. Then, pleiotropic analysis under composite null hypothesis (PLACO) with functional mapping combined annotation of genetic associations (FUMA) were conducted genes. Next, blood, brain intestine expression quantitative trait locus (eQTL) taken perform drug-target MR finding genes two diseases. Colocalization ensured eQTLs corresponding gene colocalized disease. Enrichment protein‒protein interaction (PPI) network done explore pathogenesis pathways. Genes passed all regarded as drug targets. Our revealed relationship diseases, ORs for PD IBD, CD, UC (1.050 [95% CI 1.014–1.086], 1.044 0.995–1.095], 1.063 1.016–1.120]); (1.003 0.973–1.034], 1.035 1.004–1.067], 1.008 0.977–1.040]). Overall, 277, 216 201 identified UC. Total 733 classified tier 3 (found only one tissue) druggable targets, 57 2 tissues, 51 protein-coding genes) 9 three tissues). Among 60 over 2, 18 overlapped enriched mitochondria, antigen presentation, processing immune cell regulation Three (LRRK2, RAB29 HLA-DQA2) colocalization analysis. LRRK2 reported be genes, HLA-DQA2 first time potential This study established a reliable relationship, possible pathways which had important implications intervention treatment diseases simultaneously.

Language: Английский

Citations

1
From Gut to Brain: Uncovering Potential Serum Biomarkers Connecting Inflammatory Bowel Diseases to Neurodegenerative Diseases DOI Open Access
Oliviu Florențiu Sârb,

Adriana-Daniela Sârb,

Maria Ilieș

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5676 - 5676

Published: May 23, 2024

Inflammatory bowel diseases (IBDs) are characterized by chronic gastrointestinal inflammation due to abnormal immune responses gut microflora. The gut–brain axis is disrupted in IBDs, leading neurobiological imbalances and affective symptoms. Systemic IBDs affects the brain’s inflammatory response system, hormonal axis, blood–brain barrier integrity, influencing microbiota. This review aims explore association between dysregulations serum biomarkers, development of cognitive disorders. Studies suggest a potential neurodegeneration. mechanisms include systemic inflammation, nutritional deficiency, GBA dysfunction, effect genetics comorbidities. objective identify correlations propose future research directions understand impact altered microbiomes intestinal functions on Serum levels vitamins, neuronal damage growth factors have been investigated for their predict neurodegenerative diseases, but current results inconclusive require more studies.

Language: Английский

Citations

5
Hyphae and Healthspan DOI Creative Commons
Patrick Chambers

Published: Aug. 1, 2024

Candida overgrowth (CO) can induce an avalanche of health problems. Its hyphal wall contains epitopes that trigger not only gluten type antibodies (celiac disease) but also a plethora mannan related targeting Gq coupled GPCRs. These latter disrupt autonomic receptors, inducing POTS, loss taste and smell, many other symptoms. auto-antibodies chemotactic cytokine receptors (CCRs) pain, psoriasis, alopecia areata, vitiligo maladies. They target T cells otherwise suppress latent viruses, e.g., EBV. Hyphae release candidalysin, toxin suppresses growth competing intestinal bacteria, triggers inflammasomes, causes hypercitrullination. Anti-citrullinated peptide (ACPAs) are produced. B exposed to hyper citrullination develop citrullinated receptors. ACPAs CCRs may jointly viral reactivation from infected cells. EBV, in virtually all humans now free circulate, is targeted by these same ACPAs. EBV nuclear material released antinuclear (ANAs) emerge. the histamine tryptase mast Tryptase have been tightly linked trifecta cell activation syndrome (MCAS), hypermobility spectrum disorder (HSD), POTS addition long Covid (LC) probably anti-phospholipid (APS). periodontitis. Bacteria generally considered be culprits, hyphae its biofilm facilitate their pathogenesis. Periodontitis with sentinel risk indicator for cancer, dementia, autoimmune disease, ASCVD chronic disease general. D3 tryptophan oppose invasive transition Candida, which responds releasing indoleamine dioxygenase degrades tryptophan. This altered metabolism characteristic these. Ultimately directly or indirectly involved gut dysbiosis, including periodontitis, detriment healthspan. The approach conceptual empirical.

Language: Английский

Citations

2
Reply: On the Risk of Neurological Disorders in Patients With Inflammatory Bowel Disease DOI
Mohammad Zamani, Reza Malekzadeh

Inflammatory Bowel Diseases, Journal Year: 2024, Volume and Issue: 30(7), P. 1227 - 1227

Published: April 3, 2024

Journal Article Corrected proof Reply: On the Risk of Neurological Disorders in Patients With Inflammatory Bowel Disease Get access Mohammad Zamani, MD, MD Digestive Diseases Research Center, Institute, Tehran University Medical Sciences, Tehran, Iran Search for other works by this author on: Oxford Academic PubMed Google Scholar Reza Malekzadeh, Address correspondence to: Shariati Hospital, North Kargar Avenue, 14117-13014, ([email protected]). https://orcid.org/0000-0002-9820-6335 Diseases, izae079, https://doi.org/10.1093/ibd/izae079 Published: 03 April 2024 history and typeset:

Language: Английский

Citations

1
Underneath the Gut–Brain Axis in IBD—Evidence of the Non-Obvious DOI Open Access
Lidiya V. Boldyreva, A. A. Evtushenko, Maria Lvova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12125 - 12125

Published: Nov. 12, 2024

The gut–brain axis (GBA) plays a pivotal role in human health and wellness by orchestrating complex bidirectional regulation influencing numerous critical processes within the body. Over past decade, research has increasingly focused on GBA context of inflammatory bowel disease (IBD). Beyond its well-documented effects GBA–enteric nervous system vagus nerve dysregulation, gut microbiota misbalance—IBD also leads to impairments metabolic cellular functions: mitochondrial dysfunction, cationic transport, cytoskeleton dysregulation. These systemic are currently underexplored relation GBA; however, they crucial for cells’ functioning. This review summarizes studies particular mechanisms IBD. Understanding involvement these may help find new therapeutic targets develop approaches improve quality life IBD patients.

Language: Английский

Citations

1
Pathophysiological, Neuropsychological, and Psychosocial Influences on Neurological and Neuropsychiatric Symptoms of Post-Acute COVID-19 Syndrome: Impacts on Recovery and Symptom Persistence DOI Creative Commons

Alex Malioukis,

R Sterling Snead, Julia Marczika

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2831 - 2831

Published: Dec. 13, 2024

Although the impact of post-acute COVID-19 syndrome (PACS) on patients and public health is undeniably significant, its etiology remains largely unclear. Much research has been conducted pathophysiology, shedding light various aspects; however, due to multitude symptoms clinical conditions that directly or indirectly define PACS, it challenging establish definitive causations. In this exploration, through systematically reviewing latest pathophysiological findings related neurological syndrome, we aim examine how psychosocial neuropsychological may overlap with ones, they not only serve as risk factors but also contribute persistence some primary disorder. Findings from our synthesis suggest psychological factors, such anxiety, depression, loneliness, interact in a self-reinforcing feedback loop. This cycle seems be affecting both physical distress, potentially increasing severity PACS symptoms. By pointing out interaction, review study, attempt offer new perspective interconnected nature psychological, psychosocial, emphasizing importance integrated treatment approaches disrupt improve outcomes when possible.

Language: Английский

Citations

1
Meta‐analysis: Risk of lymphoma in patients with inflammatory bowel disease in population‐based cohort studies DOI Creative Commons
Mohammad Zamani, Shaghayegh Alizadeh‐Tabari, M. Hassan Murad

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

There are inconsistencies in the results of studies investigating association between inflammatory bowel disease (IBD) and lymphoma.

Language: Английский

Citations

0
On the Risk of Neurological Disorders in Patients With Inflammatory Bowel Disease DOI
Antônio Miguel Furtado Leitão, Francisco de Assis Aquino Gondim

Inflammatory Bowel Diseases, Journal Year: 2024, Volume and Issue: 30(7), P. 1225 - 1226

Published: April 3, 2024

Journal Article Corrected proof On the Risk of Neurological Disorders in Patients With Inflammatory Bowel Disease Get access Antônio Miguel Furtado Leitão, MD, PhD, PhD Department Anatomy and Morphological Sciences, Federal University Ceará, Fortaleza, Brazil https://orcid.org/0000-0003-4590-812X Search for other works by this author on: Oxford Academic PubMed Google Scholar Francisco de Assis Aquino Gondim, FAAN Internal Medicine, Neurology Division, Address correspondence to: FAAN, Universidade do Ceará; Rua Professor Costa Mendes, 1608, CEP: 60.430-140, Fortaleza-CE, Brasil. Telephone: +55(85)3366-8052 ([email protected]). https://orcid.org/0000-0002-8957-5796 Diseases, izae074, https://doi.org/10.1093/ibd/izae074 Published: 03 April 2024 history typeset:

Language: Английский

Citations

0
Hyphae and Healthspan DOI Creative Commons
Patrick Chambers

Published: Aug. 6, 2024

Candida overgrowth (CO) can induce an avalanche of health problems. Its hyphal wall contains epitopes that trigger not only gluten type antibodies (celiac disease) but also a plethora mannan related targeting Gq coupled GPCRs. These latter disrupt autonomic receptors, inducing POTS, loss taste and smell, many other symptoms. auto-antibodies chemotactic cytokine receptors (CCRs) pain, psoriasis, alopecia areata, vitiligo maladies. They target T cells otherwise suppress latent viruses, e.g., EBV. Hyphae release candidalysin, toxin suppresses growth competing intestinal bacteria, triggers inflammasomes, causes hypercitrullination. Anti-citrullinated peptide (ACPAs) are produced. B exposed to hyper citrullination develop citrullinated receptors. ACPAs CCRs may jointly viral reactivation from infected cells. EBV, in virtually all humans now free circulate, is targeted by these same ACPAs. EBV nuclear material released antinuclear (ANAs) emerge. the histamine tryptase mast Tryptase have been tightly linked trifecta cell activation syndrome (MCAS), hypermobility spectrum disorder (HSD), POTS addition long Covid (LC) probably anti-phospholipid (APS). periodontitis. Bacteria generally considered be culprits, hyphae its biofilm facilitate their pathogenesis. Periodontitis with sentinel risk indicator for cancer, dementia, autoimmune disease, ASCVD chronic disease general. D3 tryptophan oppose invasive transition Candida, which responds releasing indoleamine dioxygenase degrades tryptophan. This altered metabolism characteristic these. Ultimately directly or indirectly involved gut dysbiosis, including periodontitis, detriment healthspan. The approach conceptual empirical.

Language: Английский

Citations

0