Should We Consider Microbiota-Based Interventions as a Novel Therapeutic Strategy for Schizophrenia? A Systematic Review and Meta-Analysis DOI Creative Commons
Lucas Hassib,

Alexandre Kanashiro,

João Francisco Cordeiro Pedrazzi

et al.

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 43, P. 100923 - 100923

Published: Dec. 11, 2024

Schizophrenia is a chronic psychiatric disorder characterized by variety of symptoms broadly categorized into positive, negative, and cognitive domains. Its etiology multifactorial, involving complex interplay genetic, neurobiological, environmental factors, its neurobiology associated with abnormalities in different neurotransmitter systems. Due to this multifactorial neurobiology, leading wide heterogeneity clinical presentations, current antipsychotic treatments face challenges, underscoring the need for novel therapeutic approaches. Recent studies have revealed differences gut microbiome individuals schizophrenia compared healthy controls, establishing an intricate link between gastrointestinal health, suggesting that microbiota-targeted interventions could help alleviate symptoms. Therefore, meta-analysis investigates whether microbiota manipulation can ameliorate psychotic outcomes patients receiving pharmacological treatment. Nine (n = 417 participants) were selected from 81 records, comprising seven randomized controlled trials two open-label studies, all low risk bias, included systematic review meta-analysis. The overall combined effect size indicated significant symptom improvement following treatment (Hedges' g 0.48, 95% CI 0.09 0.88, p 0.004, I2 62.35%). However, according Hedges' criteria, was small (approaching moderate), study moderate based on criteria. This also discusses preclinical elucidate neural, immune, metabolic pathways which manipulation, particularly Lactobacillus Bifidobacterium genera, may exert beneficial effects via gut-brain axis. Finally, we address main confounding factors identified our review, highlight key limitations, offer recommendations guide future high-quality larger participant cohorts explore microbiome-based therapies as primary or adjunctive schizophrenia.

Language: Английский

Schizophrenia: Disability, Clinical Insights, and Management DOI
Abid Rizvi, Sadia Rehman Safwi,

Mohammad Amir Usmani

et al.

Published: Jan. 1, 2024

Language: Английский

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Los receptores muscarínicos como potencial objetivo terapéutico en la esquizofrenia DOI Creative Commons

José Eduardo López Villa

eNeurobiología, Journal Year: 2024, Volume and Issue: 15(38)

Published: July 16, 2024

La esquizofrenia es una enfermedad mental crónica caracterizada por tres conjuntos de síntomas: positivos, negativos y cognitivos. Aunque los primeros han logrado abordarse con actuales fármacos antipsicóticos, un 20-30 % pacientes no muestra respuesta el perfil efectos secundarios metabólicos motores limita su uso en algunos casos. Durante mucho tiempo se explicó la presencia dichas manifestaciones clínicas hipótesis dopaminérgica; sin embargo, terminó demostrándose como explicación incompleta, a vez que involucraron otros sistemas neurotransmisores, colinérgico. En este sentido, acetilcolina ha involucrado funciones memoria, atención aprendizaje, así regulación del sistema dopaminérgico. Además antipsicóticos apuntan sus receptores muscarínicos, xanomelina emraclidina, incrementado interés ese neurotransmisor objetivo búsqueda nuevos medicamentos antipsicóticos. Así, artículo presentar revisión literatura médica relacionada implicación acetilcolina, particularmente esquizofrenia, esfuerzos desarrollo apunten directamente al

Citations

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The Less Things Change, the More They Remain the Same: Impaired Neural Plasticity as a Critical Target for Drug Development in Neuropsychiatry DOI
Joshua T. Kantrowitz, Daniel C. Javitt

Advances in neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 801 - 828

Published: Jan. 1, 2024

Language: Английский

Citations

1
Relevance of diet in schizophrenia: a review focusing on prenatal nutritional deficiency, obesity, oxidative stress and inflammation DOI Creative Commons
Viorica Rarinca,

Amalia Vasile,

Mălina Visternicu

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 13, 2024

Background/Objectives Schizophrenia is a complex mental disorder influenced by genetic and environmental factors, including dietary habits. Oxidative stress inflammation play crucial role in the pathophysiology of schizophrenia. Emerging research suggests that diet may affect schizophrenia through different biological mechanisms beyond oxidative inflammation. In particular, epigenetic changes alter expression genes related to neurodevelopment neurotransmitter systems, while neuroplasticity plays brain adaptation resilience psychiatric disorders. Methods The literature search included main available databases (Science Direct, PubMed Google Scholar), considering English language, our screening was performed based on several words such as “schizophrenia”, “diet”, “nutrients”, “obesity”, “oxidative stress”, “inflammation”, “antioxidants” “prenatal nutritional deficiency”. review focused specifically studies examining relevance schizophrenia, well prenatal deficiency, obesity, stress, associated with this disorder. Results Following literature, it found deficiencies, lack omega-3 fatty acids, vitamins D, B, during postnatal periods can have negative impact increase risk Patients imbalances antioxidant enzymes, glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), reduced levels antioxidants (vitamin E, vitamin C). These biochemical lead an markers malondialdehyde (MDA). addition, cytokine-mediated inflammation, microglial activation, intestinal dysbiosis are onset severity symptoms. Currently, there no universally accepted regimen for control. However, various diets methods being researched applied alleviate symptoms improve overall health patients, Mediterranean diet, ketogenic gluten-free DASH (Dietary Approaches Stop Hypertension) diet. Conclusion A healthy rich anti-inflammatory nutrients antioxidants, help manage reducing preventing complications, improving quality life. Omega-3 B particularly important development function. review, we aim analyze influence focusing

Language: Английский

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1
The Role of Neuroglia in the Development and Progression of Schizophrenia DOI Creative Commons

Neha S. Rawani,

Allen W. Chan,

Kathryn G. Todd

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 10 - 10

Published: Dec. 25, 2024

Schizophrenia is a complex heterogenous disorder thought to be caused by interactions between genetic and environmental factors. The theories developed explain the etiology of schizophrenia have focused largely on dysfunction neurotransmitters such as dopamine, serotonin glutamate with their receptors, although research in past several decades has indicated strongly that other factors are also involved role neuroglial cells psychotic disorders including should given more attention. Although glia were originally present brain only support neurons physical, metabolic nutritional capacity, it become apparent these variety important physiological roles abnormalities function may make significant contributions symptoms schizophrenia. In paper, we review microglia, astrocytes oligodendroglia aspects transmitter dysregulation, neuro-inflammation, oxidative stress, synaptic function, gut microbiome, myelination blood-brain barrier appear affect cause, development treatment We crosstalk oligodendrocytes effects antipsychotics neuroglia. Problems associated studies specific biomarkers for discussed.

Language: Английский

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1
A Clinically Oriented Review of New Antipsychotics for Schizophrenia DOI Creative Commons
Maria Luca, Antonina Luca, Alessandro Serretti

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 2637 - 2649

Published: Dec. 1, 2024

Currently available antipsychotics, mainly targeting the dopaminergic pathway, fail to address complexity of schizophrenic symptoms and can lead burdening adverse events. The need for innovative pharmacological options remains critical research is now focusing on development non-dopaminergic antipsychotics. This review aims summarize current literature most promising new APs (muscarinic agonists, Trace Amine Associated Receptor 1 Glycine Transporter Type inhibitors 5-HT2A antagonists) provide a clinically oriented overview their efficacy, safety potential use in schizophrenia.

Language: Английский

Citations

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A lifetime of mental health treatments for people with schizophrenia: update and narrative review DOI

Lynn E. DeLisi

Current Opinion in Psychiatry, Journal Year: 2024, Volume and Issue: 37(3), P. 140 - 146

Published: Feb. 13, 2024

Purpose of review To provide a summary the most up-to-date thoughts about treatment for schizophrenia at different stages illness. Recent findings The use Coordinated Specialty Care clinics has arisen as standard early on in psychosis, providing notion that recovery is possible. New medications do not depend postsynaptic dopamine receptor blockade are soon becoming available. Summary A focus should be made by clinicians to personalize plans each patient who possibility being diagnosed with primary psychosis and plan predict outcomes based biological markers include genetic vulnerability, psychosocial combined pharmacological treatments needed then determine or maintain going forward into future. It important individualize stage illness, well characteristics individual patient. Research ongoing advance knowledge interventions from premorbid period through chronicity.

Language: Английский

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Understanding the Impact of the Dopamine Hypothesis on Schizophrenia DOI Open Access

Jelena Stellakis,

G. Lyrakos,

Georgios Pilafas

et al.

Galore International Journal of Health Sciences and Research, Journal Year: 2024, Volume and Issue: 9(2), P. 41 - 48

Published: April 17, 2024

Schizophrenia is a mental disorder affecting approximately 24 million individuals worldwide, characterised by variety of symptoms such as delusions, hallucinations, disorganised thinking, and abnormal motor behaviour. The Dopamine Hypothesis schizophrenia suggests that an imbalance in dopamine neurotransmission plays crucial role the development this disorder. receptors their interaction with antipsychotic medication have been extensively studied context schizophrenia. Research has shown receptor block key mechanism action for neuroleptic drugs used treating Additionally, NMDA malfunction linked to manifestation schizophrenia-like symptoms, further supporting neurotransmitter dysfunction prevalence rising globally, particularly low- middle-income countries, emphasising need increased awareness resources population. Individuals often face challenges coping daily life maintaining relationships, impacting quality overall well-being. Early diagnosis, appropriate treatment, supportive services are helping manage develop mechanisms. provides valuable insights into underlying mechanisms schizophrenia, highlighting importance complex intervention comprehensive support essential improving outcomes living Keywords: Schizophrenia, Hypothesis, Neurotransmitter Dysfunction, Antipsychotic Drugs, Receptor

Language: Английский

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Diffusion magnetic resonance imaging for treatment response prediction in schizophrenia spectrum disorders: A systematic review DOI
Mohammadamin Parsaei,

Amirmahdi Sheipouri,

Paniz Partovifar

et al.

Psychiatry Research Neuroimaging, Journal Year: 2024, Volume and Issue: 342, P. 111841 - 111841

Published: June 7, 2024

Language: Английский

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Antipsychotics: beyond dopamine DOI

Mark Greener

Prescriber, Journal Year: 2024, Volume and Issue: 35(4), P. 5 - 8

Published: July 1, 2024

People with schizophrenia often experience considerable difficulties in daily life because of a wide constellation symptoms associated the condition. This article examines pharmaceutical targets that are being investigated to provide greater efficacy and tolerability than current dopamine‐focussed drugs.

Language: Английский

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