The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis

EClinicalMedicine, Journal Year: 2022, Volume and Issue: 55, P. 101762 - 101762

Published: Dec. 1, 2022

Language: Английский

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Distinguishing features of long COVID identified through immune profiling

Nature, Journal Year: 2023, Volume and Issue: 623(7985), P. 139 - 148

Published: Sept. 25, 2023

Abstract Post-acute infection syndromes may develop after acute viral disease 1 . Infection with SARS-CoV-2 can result in the development of a post-acute syndrome known as long COVID. Individuals COVID frequently report unremitting fatigue, post-exertional malaise, and variety cognitive autonomic dysfunctions 2–4 However, biological processes that are associated persistence these symptoms unclear. Here 275 individuals or without were enrolled cross-sectional study included multidimensional immune phenotyping unbiased machine learning methods to identify features Marked differences noted circulating myeloid lymphocyte populations relative matched controls, well evidence exaggerated humoral responses directed against among participants Furthermore, higher antibody non-SARS-CoV-2 pathogens observed COVID, particularly Epstein–Barr virus. Levels soluble mediators hormones varied groups, cortisol levels being lower Integration data into models identified key most strongly status. Collectively, findings help guide future studies pathobiology developing relevant biomarkers.

Language: Английский

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Impact of COVID-19 vaccination on the risk of developing long-COVID and on existing long-COVID symptoms: A systematic review

EClinicalMedicine, Journal Year: 2022, Volume and Issue: 53, P. 101624 - 101624

Published: Aug. 27, 2022

BackgroundAlthough COVID-19 vaccination decreases the risk of severe illness, it is unclear whether vaccine administration may impact prevalence long-COVID. The aim this systematic review to investigate association between and long-COVID symptomatology.MethodsMEDLINE, CINAHL, PubMed, EMBASE, Web Science databases, as well medRxiv bioRxiv preprint servers were searched up June 20, 2022. Peer-reviewed studies or preprints monitoring multiple symptoms appearing after acute SARS-CoV-2 infection either before collected by personal, telephone electronic interviews included. methodological quality was assessed using Newcastle-Ottawa Scale.FindingsFrom 2584 identified, 11 peer-reviewed six 82% (n=14/17) high. Six (n=17,256,654 individuals) investigated vaccines (vaccine-infection-long-COVID design). Overall, associated with reduced risks odds long-COVID, preliminary evidence suggesting that two doses are more effective than one dose. Eleven (n=36,736 survivors) changes in (infection-long-COVID-vaccine Seven articles showed an improvement at least dose post-vaccination, while four reported no change worsening vaccination.InterpretationLow level (grade III, case-controls, cohort studies) suggests could reduce subsequent people existing still controversial, some data showing others did not. These assumptions limited those used studies.FundingThe LONG-COVID-EXP-CM study supported a grant Comunidad de Madrid.

Language: Английский

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Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study

BMJ, Journal Year: 2023, Volume and Issue: unknown, P. e072529 - e072529

Published: Jan. 11, 2023

Abstract Objectives To determine the clinical sequelae of long covid for a year after infection in patients with mild disease and to evaluate its association age, sex, SARS-CoV-2 variants, vaccination status. Design Retrospective nationwide cohort study. Setting Electronic medical records from an Israeli healthcare organisation. Population 1 913 234 Maccabi Healthcare Services members all ages who did polymerase chain reaction test between March 2020 October 2021. Main outcome measures Risk evidence based list 70 reported outcomes unvaccinated infected matched uninfected people, adjusted age sex stratified by risk breakthrough compared controls. Risks were using hazard ratios differences per 10 000 measured during early (30-180 days) late (180-360 time periods infection. Results Covid-19 was significantly associated increased risks anosmia dysgeusia (hazard ratio 4.59 (95% confidence interval 3.63 5.80), difference 19.6 16.9 22.4) period; 2.96 (2.29 3.82), 11.0 (8.5 13.6) period), cognitive impairment (1.85 (1.58 2.17), 12.8, (9.6 16.1); 1.69 (1.45 1.96), 13.3 (9.4 17.3)), dyspnoea (1.79 (1.68 1.90), 85.7 (76.9 94.5); 1.30 (1.22 1.38), 35.4 (26.3 44.6)), weakness (1.78 (1.69 1.88), 108.5, 98.4 118.6; 1.37), 50.2 (39.4 61.1)), palpitations (1.49 (1.35 1.64), 22.1 (16.8 27.4); 1.16 (1.05 1.27), 8.3 (2.4 14.1)) significant but lower excess streptococcal tonsillitis dizziness. Hair loss, chest pain, cough, myalgia, respiratory disorders only phase. Male female showed minor differences, children had fewer than adults phase covid-19, which mostly resolved period. Findings remained consistent across variants. Vaccinated similar other patients. Conclusions This study suggests that covid-19 are at small number health outcomes, most within diagnosis.

Language: Английский

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Effect of covid-19 vaccination on long covid: systematic review

BMJ Medicine, Journal Year: 2023, Volume and Issue: 2(1), P. e000385 - e000385

Published: Feb. 1, 2023

To determine the effect of covid-19 vaccination, given before and after acute infection with SARS-CoV-2 virus, or a diagnosis long covid, on rates symptoms covid.Systematic review.PubMed, Embase, Cochrane trials, Europe PubMed Central (Europe PMC) for preprints, from 1 January 2020 to 3 August 2022.Trials, cohort studies, case-control studies reporting patients covid vaccination covid. Risk bias was assessed ROBINS-I tool.1645 articles were screened but no randomised controlled trials found. 16 observational five countries (USA, UK, France, Italy, Netherlands) identified that reported 614 392 patients. The most common studied fatigue, cough, loss sense smell, shortness breath, taste, headache, muscle ache, difficulty sleeping, concentrating, worry anxiety, memory confusion. 12 data 10 showed significant reduction in incidence covid: odds ratio developing one dose vaccine ranged 0.22 1.03; two doses, ratios 0.25-1; three 0.16; any dose, 0.48-1.01. Five infection, 0.38-0.91. high heterogeneity between precluded meaningful meta-analysis. failed adjust potential confounders, such as other protective behaviours missing data, thus increasing risk decreasing certainty evidence low.Current suggest vaccines might have therapeutic effects More robust comparative are needed, however, clearly effectiveness preventing treating covid.Open Science Framework https://osf.io/e8jdy.

Language: Английский

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Association Between BNT162b2 Vaccination and Long COVID After Infections Not Requiring Hospitalization in Health Care Workers

JAMA, Journal Year: 2022, Volume and Issue: 328(7), P. 676 - 676

Published: July 1, 2022

This study examines the risk of long COVID following mRNA vaccination, compared with no in health care workers Italy who had COVID-19 infection.

Language: Английский

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Long COVID and its Management

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(12), P. 4768 - 4780

Published: Jan. 1, 2022

The pandemic of COVID-19 is the biggest public health crisis in 21

Language: Английский

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Distinguishing features of Long COVID identified through immune profiling

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Aug. 10, 2022

SARS-CoV-2 infection can result in the development of a constellation persistent sequelae following acute disease called post-acute COVID-19 (PASC) or Long COVID 1-3 . Individuals diagnosed with frequently report unremitting fatigue, post-exertional malaise, and variety cognitive autonomic dysfunctions ; however, basic biological mechanisms responsible for these debilitating symptoms are unclear. Here, 215 individuals were included an exploratory, cross-sectional study to perform multi-dimensional immune phenotyping conjunction machine learning methods identify key immunological features distinguishing COVID. Marked differences noted specific circulating myeloid lymphocyte populations relative matched control groups, as well evidence elevated humoral responses directed against among participants Further, unexpected increases observed antibody non-SARS-CoV-2 viral pathogens, particularly Epstein-Barr virus. Analysis mediators various hormones also revealed pronounced differences, levels cortisol being uniformly lower groups. Integration data into unbiased models identified significant critical accurate classification COVID, decreased most individual predictor. These findings will help guide additional studies pathobiology may aid future objective biomarkers

Language: Английский

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Age, Sex and Previous Comorbidities as Risk Factors Not Associated with SARS-CoV-2 Infection for Long COVID-19: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(24), P. 7314 - 7314

Published: Dec. 9, 2022

Identification of predictors long COVID-19 is essential for managing healthcare plans patients. This systematic literature review and meta-analysis aimed to identify risk factors not associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, but rather potentially predictive the development COVID-19. MEDLINE, CINAHL, PubMed, EMBASE, Web Science databases, as well medRxiv bioRxiv preprint servers were screened through 15 September 2022. Peer-reviewed studies or preprints evaluating potential pre-SARS-CoV-2 infection long-lasting symptoms included. The methodological quality was assessed using Quality in Prognosis Studies (QUIPSs) tool. Random-effects meta-analyses calculation odds ratio (OR) performed those where a homogenous definition used. From 1978 identified, 37 peer-reviewed one Eighteen articles evaluated age, sixteen sex, twelve medical comorbidities Overall, single reported that old age seems be (n = 18); however, did reveal an association between 3; OR 0.86, 95% CI 0.73 1.03, p 0.17). Similarly, revealed female sex 16); which confirmed 7; 1.48, 1.17 1.86, 0.01). Finally, such pulmonary disease 4), diabetes 1), obesity 6), organ transplantation 1) also identified bias most (71%, n 27/38) moderate high. In conclusion, pooled evidence support advancing supported factor Long some previous comorbidities.

Language: Английский

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Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 22, 2023

COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional malaise, cognitive dysfunction that last for months impact everyday functioning, is referred to Long COVID under the general category post-acute sequelae SARS-CoV-2 infection (PASC). PASC highly heterogenous may be associated multisystem tissue damage/dysfunction including acute encephalitis, cardiopulmonary syndromes, fibrosis, hepatobiliary damages, gastrointestinal dysregulation, myocardial infarction, neuromuscular neuropsychiatric disorders, pulmonary damage, renal failure, stroke, vascular endothelial dysregulation. A better understanding pathophysiologic mechanisms underlying essential guide prevention treatment. This review addresses potential hypotheses connect long-term health consequences. Comparisons between other virus-initiated chronic syndromes myalgic encephalomyelitis/chronic fatigue syndrome postural orthostatic tachycardia will addressed. Aligning identifying potentially regulated common underlining pathways necessary true nature PASC. The discussed contributors include from injury one or more organs, reservoirs replicating virus its remnants in several tissues, re-activation latent pathogens Epstein-Barr herpes viruses COVID-19 immune-dysregulated environment, interactions host microbiome/virome communities, clotting/coagulation dysfunctional brainstem/vagus nerve signaling, dysautonomia autonomic dysfunction, ongoing activity primed immune cells, autoimmunity due molecular mimicry pathogen proteins. individualized suggests different therapeutic approaches required best manage specific patients.

Language: Английский

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