Benzathine penicillin G stockouts and other barriers to documented syphilis treatment in pregnancy in Zambia DOI Creative Commons
Anna V. Jones, Albert Manasyan,

Yumo Xue

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(6), P. e0304576 - e0304576

Published: June 3, 2024

Objective The prevalence of syphilis in Zambia remains high and is a critical public health concern. Zambian Ministry Health recommends universal screening same-day treatment for pregnancy, yet the rate low, poorly documented. goal this study was to document rates associated factors among pregnant women care Zambia. Methods This retrospective cohort included diagnosed with according rapid plasma reagin (RPR) during routine antenatal (ANC) Lusaka, 2018–2019. main outcome interest lack documented BPG pregnancy. Additional information about pregnancy neonatal outcomes, partner referral therapy, facility level stockout data were included. Patient characteristics compared by status using Pearson Chi-Square Test logistic regression models created estimate association between individual level-factors, type, treatment. A Cochran-Mantel-Haenszel test used evaluate facility-level significance set at p<0.05. Results Among 1,231 who screened positive clinic, 643 (52%) lacked antibiotic facility. only treat 8% sex partners had evidence therapy. Preterm delivery higher without (43% vs 32%; p = 0.003). In adjusted models, calendar year hospital type At level, annual ranged from 37–65% most (7/10) clinics reported least one BPG. Conclusion Treatment low medication stockouts common. consistent supply all ANC facilities needed facilitate timely improve birth outcomes.

Language: Английский

Knowledge, awareness and practices of healthcare workers regarding antimicrobial use, resistance and stewardship in Zambia: a multi-facility cross-sectional study DOI Creative Commons
Steward Mudenda, Billy Chabalenge, Victor Daka

et al.

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 6(3)

Published: May 6, 2024

Antimicrobial resistance (AMR) poses a threat to public health globally. Despite its consequences, there is little information about the knowledge, awareness, and practices towards AMR among healthcare workers (HCWs). Therefore, this study assessed awareness regarding antimicrobial use (AMU), stewardship (AMS) HCWs who are involved in implementation of AMS activities across eight hospitals Zambia.

Language: Английский

Citations

14
Assessment of antimicrobial resistance laboratory-based surveillance capacity of hospitals in Zambia: findings and implications for system strengthening DOI Creative Commons
Kaunda Yamba, Joseph Yamweka Chizimu, Steven Mudenda

et al.

Journal of Hospital Infection, Journal Year: 2024, Volume and Issue: 148, P. 129 - 137

Published: April 15, 2024

BackgroundA well-established antimicrobial resistance (AMR) laboratory-based surveillance (LBS) is of utmost importance in a country like Zambia which bears significant proportion the world's communicable disease burden. This study assessed capacity laboratories selected hospitals to conduct AMR Zambia.MethodsThis cross-sectional exploratory was conducted among eight (8) purposively between August 2023 and December 2023. Data were collected using self-scoring Laboratory Assessment Antibiotic Resistance Testing Capacity (LAARC) tool.FindingsOf facilities, none had full with varying capacities ranging from moderate [63% (5/8)] low [38% (3/8)]. Some barriers AMR-LBS lack electronic laboratory information system (LIS) locally generated antibiograms [75% (6/8)]. Quality control for susceptibility testing (AST), pathogen identification media preparation lowest overall score all facilities 14%, 20% 44% respectively. The highest scores specimen processing (79%), data management (78%), collection, transport, (71%) safety (70%). Most standard operating procedures (SOPs) place but lacked specimen-specific SOPs.ConclusionThe absence hinders efforts combat further complicates treatment outcomes infectious diseases. Establishing strengthening LBS systems are essential quantifying burden supporting development local guidelines.

Language: Английский

Citations

11
Global Burden of Fungal Infections and Antifungal Resistance from 1961 to 2024: Findings and Future Implications DOI Open Access
Steward Mudenda

Pharmacology &amp Pharmacy, Journal Year: 2024, Volume and Issue: 15(04), P. 81 - 112

Published: Jan. 1, 2024

Background: Antifungal resistance (AFR) is a global public health problem with devastating effects, especially among immunocompromised individuals. Addressing AFR requires One Health approach including Stewardship (AFS). This study aimed to comprehensively review studies published on fungal infections and recommend solutions address this growing problem. Materials Methods: was narrative that conducted using papers infections, AFR, AFS between January 1961 March 2024. The literature searched PubMed, Google Scholar, Web of Science, EMBASE. Results: found there has been an increase in globally, patients. Due proportionate the use antifungal agents prevent treat infections. increased worsened contributing morbidity mortality. Globally, have contributed 150 million annually 1.7 deaths per year. By year 2023, over 3.8 people died from remains challenge because treatment antifungal-resistant difficult. Finally, exacerbated by limited number invasive Conclusion: results indicated are prevalent across humans, animals, agriculture, environment. provision such as improving awareness conducting further research discovery new agents, implementing programs. If not addressed, mortality associated will continue rise future.

Language: Английский

Citations

10
Status and implications of the knowledge, attitudes and practices towards AWaRe antibiotic use, resistance and stewardship among low- and middle-income countries DOI Creative Commons
Zikria Saleem, Catrin E. Moore, Aubrey Chichonyi Kalungia

et al.

JAC-Antimicrobial Resistance, Journal Year: 2025, Volume and Issue: 7(2)

Published: March 4, 2025

There are concerns globally with rising rates of antimicrobial resistance (AMR), particularly in low- and middle-income countries (LMICs). AMR is driven by high inappropriate prescribing dispensing antibiotics, Watch antibiotics. To develop future interventions, it important to document current knowledge, attitudes practices (KAP) among key stakeholder groups LMICs. We undertook a narrative review published papers four WHO Regions including African Asian countries. Relevant were sourced from 2018 2024 synthesized group, country, Region, income level year. The findings summarized identify pertinent activities for all groups. 459 papers, large number coming Africa (42.7%). An appreciable dealt patients' KAP (33.1%), reflecting their influence on the was marked consistency across Regions, showing antibiotics viral infections despite professed knowledge AMR. similar issues dispensers. Patients' beliefs regarding effectiveness self-limiting infectious diseases major challenge, although educational programmes did improve knowledge. development AWaRe (Access, Reserve) system, practical guidance, provides opportunity standardization inputs. Similar LMICs presents clear opportunities input training based system.

Language: Английский

Citations

2
The Burden of Antimicrobial Resistance in Zambia, a Sub-Saharan African Country: A One Health Review of the Current Situation, Risk Factors, and Solutions DOI Open Access
Steward Mudenda, Webrod Mufwambi,

Shafiq Mohamed

et al.

Pharmacology &amp Pharmacy, Journal Year: 2024, Volume and Issue: 15(12), P. 403 - 465

Published: Jan. 1, 2024

Language: Английский

Citations

7
Surveillance of Antibiotic Use and Adherence to the WHO/INRUD Core Prescribing Indicators at a Primary Healthcare Hospital in Southern Zambia: Opportunities for Antimicrobial Stewardship Programs DOI Open Access
Steward Mudenda,

Ronald Simbaya,

Given Moonga

et al.

Pharmacology &amp Pharmacy, Journal Year: 2025, Volume and Issue: 16(01), P. 1 - 19

Published: Jan. 1, 2025

Background: The irrational use of medicines remains a key health problem in many developing countries. overuse antibiotics is driver antimicrobial resistance (AMR). This study surveyed antibiotic and adherence to the World Health Organization (WHO) prescribing indicators at Request Muntanga Hospital Kalomo District Southern Province, Zambia. Materials Methods: cross-sectional was conducted from July 2023 September Zambia reviewed 600 medical record prescriptions which were issued 1, 2022 June 30, using WHO indicators. collected data analyzed Statistical Package for Social Sciences version 23.0. Results: From sampled, 1246 prescribed, with making up 86.7% encounters. Additionally, average number drugs prescribed per encounter 2.1 prevalence polypharmacy 61.3%. Further, 17.8% as injectables. Furthermore, 76.7% Essential Medicines List 38.9% by generic names. Conclusions: found high deviations WHO/International Network Rational Use Drugs (INRUD) core indicating non-adherence There need promote WHO/INRUD rational prevent emergence spread AMR.

Language: Английский

Citations

1
Increased Prevalence of Antimicrobial Resistance in Vibrio cholerae in the Capital and Provincial Areas of Zambia, January 2023–February 2024 DOI Creative Commons

T Phiri,

Tadatsugu Imamura,

Peter Chibale Mwansa

et al.

American Journal of Tropical Medicine and Hygiene, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Zambia experienced the largest cholera epidemic in country’s history 2023–2024; however, antimicrobial susceptibility profile of Vibrio cholerae during is unknown. A total 2,384 stool samples were collected from suspected cases Eastern, Lusaka, and Luapula provinces January 2023 to March 2024. Among them, 549 (23.5%, n = 2,341) culture positive for V. O1, results available 431 (78.5%, 549). Sensitivity tetracycline was 84.5% ( 316 374) whereas it 100% Eastern provinces. Isolates resistant azithromycin found only Lusaka (1.6%, 1 61). ciprofloxacin 81.8% 260 318) province, other Our suggested an increased prevalence resistance against first- second-line antibiotic treatments, particularly capital. Careful monitoring regional antibiogram warranted.

Language: Английский

Citations

1
Evaluation of knowledge and practices on antibiotic use: a cross-sectional study on self-reported adherence to short-term antibiotic utilization among patients visiting level-1 hospitals in Lusaka, Zambia DOI Creative Commons
Martin Kampamba,

Bubala Hamaambo,

Christabel Nang’andu Hikaambo

et al.

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 6(4)

Published: July 3, 2024

Antimicrobial resistance (AMR) is a global public health problem affecting healthcare systems. Short-term antibiotic non-adherence thought to be one of the factors contributing resistance. This study aimed evaluate knowledge and practices towards short-term use on self-reported adherence among patients visiting level-1 hospitals in Lusaka, Zambia.

Language: Английский

Citations

4
Antimicrobial resistance profiles of and associated risk factors for Pseudomonas aeruginosa nosocomial infection among patients at two tertiary healthcare facilities in Lusaka and Copperbelt Provinces, Zambia DOI Creative Commons
Patrice Ntanda Mukomena,

Martin Simuunza,

Sody Munsaka

et al.

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 6(5)

Published: Aug. 18, 2024

Abstract Background Antimicrobial resistance (AMR) of pathogens such as Pseudomonas aeruginosa is among the top 10 threats to global health. However, clinical and molecular data are scarce in Zambia. We, therefore, evaluated AMR profiles P. nosocomial infections (NIs). Methods A year-long hospital-based cross-sectional study was conducted at two large tertiary-level hospitals Patients with current or previous hospital contact were screened for NIs. The focused on patients diagnosed Clinical specimens collected bacteriological culture, PCR amplification 16S rRNA gene fragments performed pure isolates. Hospital NIs defined that arise during hospitalization, occurring least 48 h after admission. Kirby–Bauer’s disk diffusion method used evaluate antibiotic patterns. association between risk factors analysed using χ2 test. Results Eight hundred forty-one screened, analysed. Of them, 116 (13.7%) participants’ ages ranged from 15 98 years, a mean 51 (SD ± 18). Catheter-associated urinary tract (57%) most common, followed by pressure sores (38.7%). isolates primarily susceptible amikacin, which had highest FEP. We observed high prevalence multidrug (73.6%). associated carbapenem-hydrolysing β-lactamase blaOXA-51 surgical care. Conclusions This has demonstrated multidrug-resistant prevalent Zambia’s Lusaka Ndola districts possibly countrywide.

Language: Английский

Citations

4
The World Health Organization Access, Watch, and Reserve classification of antibiotics: an awareness survey among pharmacy professionals in a sub-Saharan country, Zambia DOI Creative Commons
Steward Mudenda,

McDonald David Wataya,

Webrod Mufwambi

et al.

Antimicrobial Stewardship & Healthcare Epidemiology, Journal Year: 2024, Volume and Issue: 4(1)

Published: Jan. 1, 2024

Antimicrobial stewardship programs are very essential in addressing the problem of drug-resistant infections. The WHO Access, Watch, and Reserve (AWaRe) classification antibiotics is monitoring rational use antibiotics. Therefore, this study evaluated awareness AWaRe among pharmacy professionals Zambia.

Language: Английский

Citations

4