Translational approaches to the study of eosinophils in vasculitis
Lara D. Veeken,
Journal Year:
2025,
Volume and Issue:
64(Supplement_1), P. i19 - i23
Published: March 1, 2025
Abstract
Eosinophil
basic
biology,
including
immunoregulatory
functions,
plays
a
complex
role
in
myriad
of
disorders
where
eosinophils
play
role.
Established
vivo
and
vitro
models
novel
emerging
techniques
for
studying
are
integral
to
parsing
the
involvement
pathogenesis
vasculitis.
Knowledge
translational
approaches
from
eosinophil-associated
diseases
their
application
eosinophilic
vasculitis
highlighted.
It
is
becoming
increasingly
evident
that
roles
disease
complex.
The
use
targeted
biological
therapies
machine
learning
has
potential
reveal
contribution
pathology.
Language: Английский
Eosinophil extracellular vesicles and DNA traps in allergic inflammation
Frontiers in Allergy,
Journal Year:
2024,
Volume and Issue:
5
Published: Aug. 1, 2024
Eosinophil
granulocytes,
a
specialized
subset
of
white
blood
cells,
have
traditionally
been
associated
with
allergic
responses
and
parasitic
infections.
However,
recent
research
has
unveiled
their
versatile
roles
in
immune
regulation
beyond
these
classical
functions.
This
review
highlights
the
emerging
field
eosinophil
biology,
particular
focus
on
release
extracellular
vesicles
(EVs)
DNA
traps
(EETs).
It
further
explores
potential
implications
eosinophil-derived
EVs
EETs
for
during
inflammatory
diseases.
The
EVs/EETs
from
eosinophils,
which
also
affects
eosinophils
themselves,
may
influence
both
local
systemic
reactions,
affecting
pathophysiology
conditions
such
as
airway
inflammation,
chronic
rhinosinusitis
atopic
dermatitis.
Language: Английский