Presepsin in Critical Illness: Current Knowledge and Future Perspectives

Diagnostics, Journal Year: 2024, Volume and Issue: 14(12), P. 1311 - 1311

Published: June 20, 2024

The accurate identification of infections is critical for effective treatment in intensive care units (ICUs), yet current diagnostic methods face limitations sensitivity and specificity, alongside cost accessibility issues. Consequently, there a pressing need marker that economically feasible, rapid, reliable. Presepsin (PSP), also known as soluble CD14 subtype (sCD14-ST), has emerged promising biomarker early sepsis diagnosis. PSP, derived from CD14, reflects the activation monocytes/macrophages response to bacterial infections. It shown potential cellular immune against pathogens, with plasma concentrations increasing during decreasing post-antibiotic treatment. Unlike traditional markers such procalcitonin (PCT) C-reactive protein (CRP), PSP specifically indicates monocyte/macrophage activation. Limited studies illness have explored PSP’s role sepsis, its accuracy varies threshold values, impacting specificity. Recent meta-analyses suggest standalone effectiveness ICU infection management remains uncertain. This review provides comprehensive overview utility settings, including accuracy, prognostic value, therapeutic implications, challenges, future directions.

Language: Английский

---

Biomarkers as Predictors of Mortality in Sepsis and Septic Shock for Patients Admitted to Emergency Department: Who Is the Winner? A Prospective Study

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(19), P. 5678 - 5678

Published: Sept. 24, 2024

Background/Objectives: Sepsis and septic shock remain significant contributors to high early mortality rates among patients admitted the emergency department (ED). The objective of this study was identify newer biomarkers those with highest sensitivity in prediction. Methods: This prospective, unicentric, observational enrolled 47 adult ED between November 2020 December 2022. monitored kinetics older biomarkers, including azurocidin (AZU1), soluble triggering receptor expressed on myeloid cells (sTREM), urokinase-type plasminogen activator (suPAR), high-sensitivity C-reactive protein (hsCRP), procalcitonin (PCT), interleukin-6 (IL-6), their capacity predicting mortality. Results: SuPAR showed most predictive utility for prognosis ED, an area under curve (AUC) 0.813 (95% CI: 0.672 0.912), a cutoff value > 8168 ng/mL, 75%, specificity 81.48% (p < 0.001). IL-6 PCT comparable prognostic accuracy, whereas hsCRP AZU1 demonstrated lower performance. Conclusions: In our study, suPAR, IL-6, good short-term sepsis patients.

Language: Английский

---

The Pivotal Role of Presepsin in Assessing Sepsis-Induced Cholestasis

Diagnostics, Journal Year: 2024, Volume and Issue: 14(16), P. 1706 - 1706

Published: Aug. 6, 2024

Background: The serum levels of presepsin correlate with parameters indicating cholestasis in sepsis; however, the probability and significance this association remain uncertain. We aimed to ascertain whether infection, as signaled by levels, is primary determinant elevated biliary sepsis. Methods: A unicenter, retrospective study included 396 COVID-free emergency-admitted patients, which level was determined. Presepsin, neutrophil count, leukocyte C reactive protein, fibrinogen evaluated septic/inflammatory state. statistically significant factors associated cholestasis, ALT, AST were analyzed Fisher’s exact test Spearman regression Bonferroni’s correction. Results: Presepsin emerged most likely variable correlated all markers: alkaline phosphatase (p = 7 × 10−8), gamma-glutamyl transferase 5 10−10), conjugated bilirubin 4 10−15). Thrombocyte age, creatinine, urea, lactate, blood pressure, only one or two these markers. Conclusions: In a sepsis setting, increase cholestasis-related higher than hemodynamic, inflammatory, coagulation-related variables. Determining robust link between could eliminate unnecessary imaging procedures critically ill enabling clinicians focus efforts on addressing infectious cause.

Language: Английский

---

Can We Improve Mortality Prediction in Patients with Sepsis in the Emergency Department?

Medicina, Journal Year: 2024, Volume and Issue: 60(8), P. 1333 - 1333

Published: Aug. 16, 2024

: Sepsis represents a global health challenge and requires advanced diagnostic prognostic approaches due to its elevated rate of morbidity fatality. Our study aimed assess the value novel set six biomarkers combined with severity scores in predicting 28 day mortality among patients presenting sepsis Emergency Department (ED).

Language: Английский

---