The Role of Neuroglia in the Development and Progression of Schizophrenia DOI Creative Commons

Neha S. Rawani,

Allen W. Chan,

Kathryn G. Todd

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 10 - 10

Published: Dec. 25, 2024

Schizophrenia is a complex heterogenous disorder thought to be caused by interactions between genetic and environmental factors. The theories developed explain the etiology of schizophrenia have focused largely on dysfunction neurotransmitters such as dopamine, serotonin glutamate with their receptors, although research in past several decades has indicated strongly that other factors are also involved role neuroglial cells psychotic disorders including should given more attention. Although glia were originally present brain only support neurons physical, metabolic nutritional capacity, it become apparent these variety important physiological roles abnormalities function may make significant contributions symptoms schizophrenia. In paper, we review microglia, astrocytes oligodendroglia aspects transmitter dysregulation, neuro-inflammation, oxidative stress, synaptic function, gut microbiome, myelination blood-brain barrier appear affect cause, development treatment We crosstalk oligodendrocytes effects antipsychotics neuroglia. Problems associated studies specific biomarkers for discussed.

Language: Английский

Neuroinflammatory Loop in Schizophrenia, Is There a Relationship with Symptoms or Cognition Decline? DOI Open Access
Claudio Carril Pardo, Karina Oyarce, América Vera-Montecinos

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 310 - 310

Published: Jan. 1, 2025

Schizophrenia (SZ), a complex psychiatric disorder of neurodevelopment, is characterised by range symptoms, including hallucinations, delusions, social isolation and cognitive deterioration. One the hypotheses that underlie SZ related to inflammatory events which could be partly responsible for symptoms. However, it unknown how molecules can contribute decline in SZ. This review summarises exposes possible contribution imbalance between pro-inflammatory anti-inflammatory interleukins like IL-1beta, IL-4 TNFalfa among others on impairment. We discuss this affects microglia astrocytes inducing disruption blood–brain barrier (BBB) SZ, impact prefrontal cortex or associative areas involved executive functions such as planning working tasks. also highlight generated intestinal microbiota alterations, due dysfunctional microbial colonisers use some anti-psychotics, central nervous system. Finally, question arises whether modulate correct characterises if an immunomodulatory strategy incorporated into conventional clinical treatments, either alone complement, applied specific phases, prodromal first-episode psychosis.

Language: Английский

Citations

1
Urolithin A ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling DOI
Zhengyuan Huang, Guang‐Hui Chen,

Zhongyu Ren

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114336 - 114336

Published: Feb. 22, 2025

Language: Английский

Citations

1
Unraveling the potential of neuroinflammation and autophagy in schizophrenia DOI

Hongxia Tao,

Cheng‐Xiang Wang, Chuan Zou

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 997, P. 177469 - 177469

Published: March 5, 2025

Language: Английский

Citations

0
Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis DOI

Xiumei Zhu,

Xi Chen,

Huajie Ba

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions DOI Open Access
América Vera-Montecinos, Belén Ramos

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3653 - 3653

Published: April 12, 2025

Despite the emerging evidence of role transcriptional regulators in schizophrenia as key molecular effectors responsible for dysregulation multiple biological processes, limited information is available brain areas that control higher cognitive functions, such cerebellum. To identify transcription factors could a wide panel altered proteins cerebellar cortex schizophrenia, we analyzed dataset obtained using one-shot liquid chromatography–tandem mass spectrometry on postmortem human chronic (PXD024937 identifier ProteomeXchange repository). Our analysis revealed 11 enriched (SP1, KLF7, SP4, EGR1, HNF4A, CTCF, GABPA, NRF1, NFYA, YY1, and MEF2A) be controlling 250 proteins. The top three significantly were SP1, with largest number targets SP4 which belong to Krüppel superfamily. An enrichment vesicle-mediated transport was found MEF2A targets, while pathways related signaling, inflammation/immune responses, apoptosis, energy SP1 KLF7 targets. EGR1 RNA processing, GABPA YY1 mainly involved organelle organization assembly. This study provides reduced impact through cerebellum schizophrenia. These findings suggest this represent pharmacological interventions

Language: Английский

Citations

0
The Role of Neuroglia in the Development and Progression of Schizophrenia DOI Creative Commons

Neha S. Rawani,

Allen W. Chan,

Kathryn G. Todd

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 10 - 10

Published: Dec. 25, 2024

Schizophrenia is a complex heterogenous disorder thought to be caused by interactions between genetic and environmental factors. The theories developed explain the etiology of schizophrenia have focused largely on dysfunction neurotransmitters such as dopamine, serotonin glutamate with their receptors, although research in past several decades has indicated strongly that other factors are also involved role neuroglial cells psychotic disorders including should given more attention. Although glia were originally present brain only support neurons physical, metabolic nutritional capacity, it become apparent these variety important physiological roles abnormalities function may make significant contributions symptoms schizophrenia. In paper, we review microglia, astrocytes oligodendroglia aspects transmitter dysregulation, neuro-inflammation, oxidative stress, synaptic function, gut microbiome, myelination blood-brain barrier appear affect cause, development treatment We crosstalk oligodendrocytes effects antipsychotics neuroglia. Problems associated studies specific biomarkers for discussed.

Language: Английский

Citations

1