Intestinal IL-17 family orchestrates microbiota-driven histone deacetylation and promotes Treg differentiation to mediate the alleviation of asthma by Ma-Xing-Shi-Gan decoction

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156656 - 156656

Published: March 1, 2025

Language: Английский

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Short-term exposures to PM2.5, PM2.5 chemical components, and antenatal depression: Exploring the mediating roles of gut microbiota and fecal short-chain fatty acids

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 277, P. 116398 - 116398

Published: April 26, 2024

PM2.5 and its chemical components increase health risks are associated with depression gut microbiota. However, there is still limited evidence on whether microbiota short-chain fatty acids (SCFAs) mediate the association between PM2.5, components, antenatal depression. The purpose of this study was to investigate mediating role maternal in correlations short-term exposure Demographic information stool samples were collected from 75 pregnant women their third trimester. Their measured. Participants divided into non-antenatal group or according cut-off 10 points Edinburgh Postnatal Depression Scale (EPDS). analyzed using 16 S rRNA-V3/V4 gene sequence, concentration calculated Tracking Air Pollution China (TAP) database. Gas chromatography–mass spectrometry used analyze SCFAs samples. In order assess effects SCFAs, mediation models utilized. There significant differences microbial composition concentrations group. positively EPDS scores negatively genera Enterococcus Enterobacter. Genera Candidatus_Soleaferrea (β = −7.21, 95%CI −11.00 −3.43, q 0.01) −2.37, −3.87 −0.87, 0.02) scores, indicating potential protective against no scores. different lagged periods component exposure, revealed. For instance, explained 29.23% (95%CI 2.16–87.13%, p 0.04) associations level at day sampling (lag 0) Our highlights that may mechanism through which influences PM2.5-induced needs be further studied.

Language: Английский

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Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(10), P. 5837 - 5855

Published: Aug. 6, 2023

Chronic diarrhea, including diarrhea-predominant irritable bowel syndrome (IBS-D), osmotic bile acid and antibiotic-associated is a common problem which highly associated with disorders of the gut microbiota composition such as small intestinal bacterial overgrowth (SIBO) so on. A growing number studies have supported view that Chinese herbal formula alleviates symptoms diarrhea by modulating fecal microbiota. polysaccharides (CHPs) are natural polymers composed monosaccharides widely found in herbs function important active ingredients. Commensal has an extensive capacity to utilize CHPs play vital role degrading into short-chain fatty acids (SCFAs). Many CHPs, prebiotics, antidiarrheal promote growth beneficial bacteria inhibit colonization pathogenic bacteria. This review systematically summarizes relationship among microbiota, chronic well recent progress on impacts advances possible diarrhea.

Language: Английский

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Identification and structural characterization of key prebiotic fraction of soluble dietary fiber from grapefruit peel sponge layer and its regulation effect on gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129274 - 129274

Published: Jan. 8, 2024

Language: Английский

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A new perspective on gut-lung axis affected through resident microbiome and their implications on immune response in respiratory diseases

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(3)

Published: Feb. 18, 2024

Language: Английский

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Exploring the intestinal ecosystem: from gut microbiota to associations with subtypes of inflammatory bowel disease

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 4, 2024

Objective Significant differences have been discovered between subtypes of Crohn’s disease (CD) and ulcerative colitis (UC). The role gut microbiota in promoting the onset UC CD is established, but conclusions regarding subtype-specific analyses remain limited. Methods This study aims to explore influence on CD, offering novel insights into pathogenesis treatment CD.Two-sample Mendelian randomization (MR) analysis was employed examine causal relationship composition. Gut data were sourced from International Consortium MiBioGen, while obtained FINNGEN. Eligible single nucleotide polymorphisms (SNPs) selected as instrumental variables. Multiple analytical approaches such inverse variance-weighted (IVW), MR-Egger regression, weighted median, mode, MR-RAPS utilized. Sensitivity including intercept test, Cochran’s Q leave-one-out conducted for quality control. Subsequently, we multivariable IVW, MR-Egger, LASSO regression methods identify independently significant genera or families sensitivity analyses. Results We determined that Hungatella , Acidaminococcaceae 15 other microbial taxa act protective factors various subtypes, Terrisporobacter Anaerostipes 23 are associated with increased risk different subtypes. Furthermore, through MR analysis, identified independent effects. Conclusion Our confirms a dysbiosis occurrence it validates etiological distinctions among UC. A approach adjunctive therapy involving distinct may involve use probiotics represents potential avenue future treatments.

Language: Английский

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The great potential of polysaccharides from natural resources in the treatment of asthma: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129431 - 129431

Published: Jan. 16, 2024

Language: Английский

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Polysaccharides play an anti-fibrotic role by regulating intestinal flora: A review of research progress

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 131982 - 131982

Published: May 8, 2024

Language: Английский

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Mechanism investigation of Forsythoside A against esophageal squamous cell carcinoma in vitro and in vivo

Cancer Biology & Therapy, Journal Year: 2024, Volume and Issue: 25(1)

Published: July 24, 2024

Context Forsythoside A (FSA) was extracted from Forsythia suspensa, a traditional Chinese medicine, which has been demonstrated to exert anti-inflammatory, antibacterial, and other pharmacological effects. However, the anticancer effect of FSA in esophageal squamous cell carcinoma (ESCC) not documented.

Language: Английский

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Integrated Network Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Sijunzi Decoction Involved in Alleviating Airway Inflammation in a Mouse Model of Asthma

Evidence-based Complementary and Alternative Medicine, Journal Year: 2023, Volume and Issue: 2023(1)

Published: Jan. 1, 2023

Asthma is a chronic inflammatory disease of the airways with recurrent attacks, which seriously affects patients' quality life and even threatens their lives. The can threaten lives patients. Sijunzi decoction (SJZD), classical Chinese medicine formula long history administration, basic used for treatment asthma demonstrates remarkable efficacy. However, underlying mechanism has not been elucidated.We aimed to integrate network pharmacology intestinal flora sequencing analysis study SJZD in allergic asthmatic mice. active compounds asthma-related targets were predicted by various databases. We performed Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses identify potentially relevant pathways target genes. Furthermore, compound-target target-signaling pathway maps constructed using Cytoscape 3.8.2. These results combined those influence on airway inflammation mice.We obtained 137 from associated them 1445 acquired A total 109 common identified. visualized maps. pathological score suggested that could alleviate Sequencing showed increase abundance beneficial bacterial genus maintain balance flora. core toll-like receptor (TLR) signaling was identified based analysis, important role TLRs play organismal immunity also recognized. correlation between environmental factors revealed genera negatively correlated TLR2 positively TLR7 expression. they IFN-γ IL-10 levels IL-4 IL-17 levels.SJZD alleviated state findings suggest increasing bacteria mice asthma, regulating flora, interfering level expression adjust secretion factors, alleviating may be possible involved SJZD, providing basis further studies SJZD.

Language: Английский

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