Plant-Based Dietary Fibers and Polysaccharides as Modulators of Gut Microbiota in Intestinal and Lung Inflammation: Current State and Challenges

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3321 - 3321

Published: July 26, 2023

Recent research has underscored the significant role of gut microbiota in managing various diseases, including intestinal and lung inflammation. It is now well established that diet plays a crucial shaping composition microbiota, leading to changes metabolite production. Consequently, dietary interventions have emerged as promising preventive therapeutic approaches for these diseases. Plant-based fibers, particularly polysaccharides oligosaccharides, attracted attention potential agents modulating alleviating This comprehensive review aims provide an in-depth overview current state this field, emphasizing challenges limitations associated with use plant-based fibers By shedding light on existing issues limitations, seeks stimulate further development area intervention.

Language: Английский

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Microbiota Alterations in Lung, Ileum, and Colon of Guinea Pigs with Cough Variant Asthma

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2449 - 2449

Published: Feb. 19, 2024

Alterations in the microbiota composition, or ecological dysbiosis, have been implicated development of various diseases, including allergic diseases and asthma. Examining relationship between alterations host cough variant asthma (CVA) may facilitate discovery novel therapeutic strategies. To elucidate diversity difference across three niches, we performed 16S rDNA amplicon sequencing on lung, ileum, colon samples. We assessed levels interleukin-12 (IL-12) interleukin-13 (IL-13) guinea pig bronchoalveolar lavage fluid using enzyme-linked immunosorbent assay (ELISA). applied Spearman’s analytical method to evaluate correlation cytokines. The results demonstrated that relative abundance, α-diversity, β-diversity microbial composition varied considerably. ELISA indicated a substantial increase level IL-13 decreasing trend IL-12 CVA pigs. Spearman analysis identified Mycoplasma, Faecalibaculum, Ruminococcus inflammatory factors Our model showed core microorganisms, such as Mycoplasma Faecalibaculum colon, play crucial role pathogenesis CVA. most conspicuous changes niche were observed followed by while relatively minor colon. Notably, structure ileum approximated niche. Therefore, this study suggest is closely related dysregulation ileal, ensuing lung.

Language: Английский

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A new evaluation system for drug–microbiota interactions

iMeta, Journal Year: 2024, Volume and Issue: 3(3)

Published: May 7, 2024

The drug response phenotype is determined by a combination of genetic and environmental factors. high clinical conversion failure rate gene-targeted drugs might be attributed to the lack emphasis on factors inherent individual variability in (IVDR). Current evidence suggests that variables, rather than disease itself, are primary determinants both gut microbiota composition metabolism. Additionally, differences create unique metabolic environment influences vivo processes underlying absorption, distribution, metabolism, excretion (ADME). Here, we discuss how microbiota, shaped factors, affects host's ADME microenvironment within new evaluation system for drug-microbiota interactions. Furthermore, propose top-down research approach investigate intricate nature interactions vivo. This utilizes germ-free animal models, providing foundation development

Language: Английский

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Polygonatum odoratum polysaccharide ameliorates the allergic airway inflammation through regulating the gut microbiota and inhibiting gut-lung migration of ILC2s

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 118, P. 106276 - 106276

Published: June 8, 2024

Language: Английский

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Research progress on the mechanism of traditional Chinese medicine regulating intestinal microbiota to combat influenza a virus infection

Virology Journal, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 13, 2023

Abstract Influenza A viruses (IAV) are a prevalent respiratory pathogen that can cause seasonal flu and global pandemics, posing significant public health threat. Emerging research suggests IAV infections may disrupt the balance of gut microbiota, while dysbiosis affect disease progression in patients. Therefore, restoring microbiota represent promising therapeutic target for infections. Traditional Chinese medicine, with its ability to regulate offers potential preventing treating IAV. This article provides comprehensive review relationship between highlighting impact on It also explores mechanisms role traditional medicine regulating prevention treatment IAV, presenting novel avenues medicine-based treatments.

Language: Английский

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Microbiota, metabolites and mucosal immunity as potential targets of traditional Chinese medicine for respiratory diseases based on the lung-gut crosstalk

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 10, P. 100374 - 100374

Published: Jan. 24, 2024

In recent years, with the advancement of life sciences, theories Traditional Chinese medicine (TCM) have been scientifically elucidated, particularly integration TCM theory "the lung and large intestine are interrelated" modern scientific "lung-gut axis". The emphasizes close relationship between gut, lung-gut microbiota, metabolites mucosal immunity acting as bridges. Databases such National Center for Biotechnology Information (NCBI), ScienceDirect, Web Science China Knowledge Infrastructure (CNKI) were used search literature by keywords "Traditional medicine", "Gut Microbiota", "Metabolites", "Mucosal Immunity", "Respiratory Diseases" so on, articles selected according to their credibility impact then reviewed. has made significant progress in treatment respiratory diseases based on axis theory. can repair damaged intestinal barriers, maintain stability microbiota related metabolites, improve immune function, thereby reduce incidence system diseases. homeostasis through multi-target multi-pathway, improving clinical symptoms therapy is a new direction exploring methods.

Language: Английский

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Mapping multi-omics characteristics related to short-term PM2.5 trajectory and their impact on type 2 diabetes in middle-aged and elderly adults in Southern China

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 468, P. 133784 - 133784

Published: Feb. 15, 2024

Language: Английский

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Mechanistic insights into targeting caspase‐3 activation and alveolar macrophage pyroptosis by Ephedra and bitter almond compounds for treating pediatric pneumonia via network pharmacology and bioinformatics

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(4)

Published: April 1, 2024

Abstract This study investigates the molecular mechanism of Ma Huang‐Ku Xing Ren, a traditional Chinese medicine formula, in treating pediatric pneumonia. The focus is on regulation caspase‐3 activation and reduction alveolar macrophage necrosis through network pharmacology bioinformatics analyses Ephedra bitter almond components. Active compounds targets from ephedrine were obtained using TCMSP, TCMID, GeneCards databases, identifying pneumonia‐related genes. A protein–protein interaction (PPI) was constructed, core screened. GO KEGG pathway enrichment identified relevant genes pathways. An acute pneumonia mouse model created lipopolysaccharide (LPS) inhalation method, with overexpression induced by lentivirus. mice treated gastric lavage. Lung tissue damage, inflammatory markers (IL‐18 IL‐1β), cell death‐related gene assessed H&E staining, ELISA, western blot, flow cytometry, immunofluorescence. 128 active 121 almond. PPI revealed 13 proteins, analysis indicated involvement inflammation, apoptosis, necrosis, particularly pathway. In vivo results showed that treatment significantly mitigated LPS‐induced lung injury mice, reducing scores marker levels. It also decreased activity death macrophages. conclusion, ingredients targeting caspase‐3, may effectively treat apoptosis macrophages, as demonstrated both pharmacology, analyses, experimental data.

Language: Английский

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Traditional Chinese medicine to improve immune imbalance of asthma: focus on the adjustment of gut microbiota

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 1, 2024

Asthma, being the prevailing respiratory ailment globally, remains enigmatic in terms of its pathogenesis. In recent times, advancement traditional Chinese medicine pertaining to intestinal microbiota has yielded a plethora investigations, which have substantiated potential disease prevention and treatment through modulation microbiota. Both animal models clinical trials unequivocally demonstrated indispensable role pathogenesis asthma. This article presents summary therapeutic effects context regulating gut metabolites, thereby achieving immune regulation inhibiting airway inflammation associated with It elucidates mechanism by modulates enhance asthma management, offering scientific foundation for utilization

Language: Английский

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The molecular mechanism of polysaccharides in combating major depressive disorder: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 259, P. 129067 - 129067

Published: Dec. 30, 2023

Language: Английский

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