Journal of Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 15(10)
Published: Oct. 1, 2023
Language: Английский
Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 260, P. 108684 - 108684
Published: July 2, 2024
Language: Английский
Citations
6
Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(12)
Published: March 18, 2025
To understand infectious disease dynamics, we need to the inextricably intertwined nature of ecology and evolution pathogens hosts. Epidemiological dynamics many diseases have highlighted importance considering demographics societies in which they spread, particularly with respect age structure. In addition, waves recent COVID-19 pandemic driven by variant replacements at an unprecedented speed show that it is vital consider evolutionary aspects. The classic trade-off theory virulence addresses aspects pathogen evolution, but here explore more detail possibility society-specific evolutionarily stable strategies (ESS) during unfolding pandemic. Theory posits existence under some conditions ESS representing endpoint change. By using a demographically realistic model incorporating infection rates vary age, outline scenarios are plausible. Focusing on rate duration infectivity, ask whether exists, what characterizes it, as result long-term public-health consequences may be expected. We demonstrate evolving depends upon background age-dependent frailty mortality rates. Our findings shed important light plausible trajectories highly evolvable novel pathogens.
Language: Английский
Citations
0
Virologica Sinica, Journal Year: 2024, Volume and Issue: 39(6), P. 845 - 850
Published: April 30, 2024
In recent years, substantial advancements have been achieved in understanding the diversity of human virome and its intricate roles health diseases. Despite this progress, field research remains nascent, primarily hindered by absence effective methods, particularly domain computational tools. This perspective systematically outlines ten challenges spanning various types studies. These arise due to vast viromes, a universal marker gene viral genomes, low abundance virus populations, remote or minimal homology proteins known proteins, highly dynamic heterogeneous nature viromes. For each challenge, we discuss underlying reasons, current potential solutions. The resolution these necessitates ongoing collaboration among scientists, virologists, multidisciplinary experts. essence, serves as comprehensive guide for directing efforts
Language: Английский
Citations
2
BioEssays, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 14, 2024
Abstract A recent thought‐provoking theory argues that complex organisms using epigenetic information for their normal development and functioning must irreversibly age as a result of signal loss. Importantly, the scope this could be considerably expanded, with scientific benefits, by analyzing ageing beyond borders Tree Life. Viruses use signals may also age, is, present an increasing risk failing to complete individual life cycle disappear time. As viruses are ancient, abundant, infect considerable diversity hosts, virus hypothesis, if verified, would have important consequences many fields Life sciences. Uncovering integrate most abundant biologically central entities on Earth into theories ageing, enhance virology, gerontology, evolutionary biology, molecular ecology, genomics, possibly medicine through new therapies manipulating viral ageing.
Language: Английский
Citations
1
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 89, P. 101982 - 101982
Published: June 15, 2023
Language: Английский
Citations
3
Cells, Journal Year: 2023, Volume and Issue: 12(18), P. 2287 - 2287
Published: Sept. 15, 2023
The spreading of senescent cells' burden holds profound implications for frailty, prompting the exploration novel therapeutic targets. In this perspective review, we delve into intricate mechanisms underlying cell spreading, its and development. We have focused our attention on emerging age-related biological factors, such as microbiome virome alterations, elucidating their significant contribution to loss control over accumulation rate cells, particularly affecting key frailty domains, musculoskeletal system cerebral functions. believe that gaining an understanding these could not only aid in involvement cellular senescence but also offer diverse possibilities, potentially advancing future development tailored interventions highly patients.
Language: Английский
Citations
2
The Journal of Physiology, Journal Year: 2023, Volume and Issue: 602(11), P. 2401 - 2415
Published: Sept. 26, 2023
Traditionally defined as the science of living, or field that beyond anatomical structure and bodily form studies functional organization behaviour, physiology has long been excluded from evolutionary research. The main reason for this exclusion is a presential futuristic outlook on life, while theory traditionally study natural history. In paper, I re-evaluate these classic divisions situate within history sciences, well debates Extended Evolutionary Synthesis need Third Way Evolution. then briefly point out how in particular contributes to research function, causation, teleonomy, agency cognition.
Language: Английский
Citations
2
Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(7)
Published: July 1, 2023
Abstract Coinfection with hepatitis C virus (HCV) and human immunodeficiency (HIV) increases immune activation, inflammation, oxidative stress that could lead to premature senescence. Different HCV infections, either acute or chronic infection, distinct cellular senescence in people living HIV (PLWHIV). Observational study 116 PLWHIV under antiretroviral treatment different status: (i) n = 45 chronically infected (CHC); (ii) 36 individuals who spontaneously clarify (SC); (iii) 35 controls. Oxidative biomarkers were analyzed at lipid, DNA, protein, nitrates levels, as well antioxidant capacity glutathione reductase enzyme. Replicative was evaluated by relative telomere length (RTL) measurement. Additionally, 26 markers of Senescence‐Associated Secretory Phenotype (SASP) multiplex immunoassays (Luminex xMAP technology). Differences generalized linear model (GLMs) adjusted most significant covariates. The SC group had a signature similar the control slightly lower SASP levels. However, differences observed respect CHC group, where an increase nitrate concentration [adjusted arithmetic mean ratio, aAMR 1.73 (1.27–2.35), p < 0.001, q 0.009] secretion 13 SASP‐associated factors [granulocyte macrophage colony‐stimulating factor (GM‐CSF), interferon‐β, interleukin (IL)‐1β, IL‐2, IL‐8, IL‐13, tumor necrosis (TNF)‐α, IL‐1α, IL‐1RA, IL‐7, IL‐15, C‐X‐C motif chemokine ligand 10 (IP‐10), stem cell (SCF); 0.1)] detected. also showed higher values IP‐10, placental growth 1 (PIGF‐1) than profile which indicate more efficient viral‐induced due their strengths. Chronic infection led elevated favoring establishment viral persistence.
Language: Английский
Citations
1
Journal of Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 15(10)
Published: Oct. 1, 2023
Language: Английский
Citations
1