Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

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Pilot work of the 10K Chinese People Genomic Diversity Project along the Silk Road suggests a complex east-west admixture landscape and biological adaptations

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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Population genomics of Central Asian peoples unveil ancient Trans-Eurasian genetic admixture and cultural exchanges

hLife, Journal Year: 2024, Volume and Issue: 2(11), P. 554 - 562

Published: June 26, 2024

Central Asia, a crucible of prehistoric and historical Trans-Eurasian interactions, has been pivotal in shaping cultural exchanges, population dynamics, genetic admixture. Recent insights from ancient DNA studies have shed light on the extensive turnover within this region, encompassing spectrum groups Paleolithic hunter-gatherers to Holocene herders nomadic pastoralist empires times. The genomic analysis pathogens across Eurasian steppe further deepened our understanding pathogen origins, clonal expansions, intricate processes host-pathogen coevolution relation varying exposures their spread. We consolidate latest findings pertaining human genomes elucidating profound influence tapestry contemporary Asians. A notable gap current databases for Asia is underscored, particularly scope genomics-driven precision medicine. stress urgent need development extensive, region-specific resources that hold promise revealing blueprints underlying traits diseases, refining polygenic scoring models predictive medicine, bolstering research endeavors Asia.

Language: Английский

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Forensic investigative genetic genealogy: expanding pedigree tracing and genetic inquiry in the genomic era

Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Genetic genealogy provides crucial insights into the complex biological relationships within contemporary and ancient human populations by analyzing shared alleles chromosomal segments that are identical descent, to understand kinship, migration patterns, population dynamics. Within forensic science, investigative genetic (FIGG) has gained prominence leveraging next-generation sequencing technologies population-specific genomic resources, opening new avenues. In this review, we synthesize current knowledge, underscore recent advancements, discuss growing role of FIGG in genomics. been pivotal revitalizing dormant inquiries offering leads numerous cold cases. Its effectiveness relies on extensive SNP profiles contributed individuals from diverse specialized databases. Advances computational genomics growth databases have spurred a profound shift application across forensics, anthropology, DNA studies. As field progresses, is evolving nascent practice more sophisticated discipline, shaping future investigations.

Language: Английский

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Perspectives and opportunities in forensic human, animal, and plant integrative genomics in the Pangenome era

Forensic Science International, Journal Year: 2025, Volume and Issue: 367, P. 112370 - 112370

Published: Jan. 12, 2025

Language: Английский

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YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

The advancements in second-/third-generation sequencing technologies, alongside computational innovations, have significantly enhanced our understanding of the genomic structure Y-chromosomes and their unique phylogenetic characteristics. These researches, despite challenges posed by lack population-scale databases, potential to revolutionize approach high-resolution, population-specific Y-chromosome panels databases for anthropological forensic applications. This study aimed develop highest-resolution Y-targeted panel, utilizing time-stamped, core informative mutations identified from high-coverage sequences YanHuang cohort. panel is intended provide a new tool complex pedigree search paternal biogeographical ancestry inference, as well explore general patterns fine-scale evolutionary history ethnolinguistically diverse Chinese populations. performance East Asian-specific Y-chromosomal including 2999-core SNP variants, was found be robust reliable. YHSeqY3000 designed capture genetic diversity lineages 3500 years ago, identifying 408 terminal 2097 individuals across 41 genetically geographically distinct We substructure that correlating with ancient population migrations expansions. New evidence provided extensive gene flow events between minority ethnic groups Han people, based on integrative Paternal Genomic Diversity Database. work successfully integrated Y-chromosome-related basic science translational applications, emphasizing necessity comprehensively characterizing genomically under-representative particularly important second phase medical or cohorts, where dense sampling strategies are employed.

Language: Английский

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Paternal genetic landscape of contemporary Thai populations in the borderland provinces of Thailand and Myanmar

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 21, 2025

This study investigates the genetic structure and demographic history of contemporary Thai populations from Tak Ranong, two border provinces between Thailand Myanmar with complex immigration histories. We analyzed 20 Y-SNP markers (327 samples) 24 Y-STR profiles (241 samples), along published datasets, observed significant differentiation these regions. is dominated by O2a2b1a1a (44.53%) O1b1a1a (21.17%). The presence NO1 (14.6%) suggests contributions nearby such as Karen, Lawa, Khuen. Notably, shows low gene diversity (GD) at DYS391 (0.2208), contrasting Ranong (0.5247) overall population (0.4708). exhibits a more diverse haplogroup distribution, prominent frequencies (20.75%), F (16.98%) (13.21%). haplogroups K (11.32%) R* (7.55%) reflects connection Maniq or other mainland Negrito groups, well historical flow South Asia. These findings enhance our understanding landscape shaped migration localized admixture. also expanded Y-chromosome database novel haplotypes, updated forensic parameters Y-haplogroup frequencies, providing valuable resources for paternal ancestry inference kinship verification in both science genetics.

Language: Английский

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Earliest sustained settlement by farmers and symbiotic relationship with foragers at high altitude on the Tibetan Plateau

Quaternary Science Reviews, Journal Year: 2025, Volume and Issue: 356, P. 109305 - 109305

Published: March 14, 2025

Language: Английский

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Genetic genealogy of Y-chromosome in the Zhetiru tribe of the Kazakh population from Kazakhstan

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: March 24, 2025

Introduction The Y chromosome, transmitted exclusively through the paternal line, is a well-established tool for verifying genealogical data. Kazakh tribe Zhetiru in Kazakhstan, comprising seven clans, has conflicting historical and narratives regarding its origin—either as union of independent clans or descendants single common ancestor. A detailed genetic investigation not yet addressed this question. Methods 350 male volunteers from were analyzed using 23 Y-STR loci 17 Y-SNPs. We calculated distances Arlequin STRAF, explored structure with median-joining networks comparative dataset over 3,000 individuals. Results At tribal level, haplotype diversity (0.997) haplogroup (0.91) are high. However, at clan haplotypic decreases, revealing clear founder effects main haplogroups Kerderi (R1a1a), Kereit (N1a2), Tama (C2a1a3), Teleu (J2a2). structures Zhagalbaily, Ramadan, Tabyn indicate additional sub-clan founders. ages key clusters suggest stable lineages 1,000 years. do form distinct cluster among tribes but demonstrate affinities others. Conclusion This study demonstrates effective application genealogy approaches records concerning determining origin distinct, genetically clans.

Language: Английский

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Fine-scale biogeographical ancestry inference in Southeast and East Asians via high-efficiency markers and machine learning approaches

Frontiers in Ecology and Evolution, Journal Year: 2025, Volume and Issue: 13

Published: April 3, 2025

Biogeographical ancestry inference offers valuable clues for forensic cold cases, but limited information is typically obtained from substructured populations within continental East Asian and Southeast groups. This study presents an integrative genomic dataset of 3,461 individuals Asia to elucidate the fine-scale population substructure its role in precision medicine. Six nested panels were developed with increasing ancestry-informative marker (AIM) density (ranging 50 2,000 SNPs) distinguish fine genetic differences between six language groups Sino-Tibetan family. We found that 2000 AIM panel exhibited differentiation efficiency PCA comparable all loci. Additionally, we constructed a classification machine learning model average prediction accuracy 84%, highlighting critical geographical improving accuracy. Furthermore, validated deep method Locator predicting coordinates solely based on information. work highlights power integrating geographic data artificial intelligence refine biogeographical inference, offering more profound insights into structure Asia, significant implications applications.

Language: Английский

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