Changes in cytokines and fibrotic growth factors after low-carbohydrate or low-fat low-energy diets in females with lipedema

Current Developments in Nutrition, Journal Year: 2025, Volume and Issue: 9(3), P. 104571 - 104571

Published: Feb. 21, 2025

Lipedema is considered an inflammation-related disease, and low-carbohydrate ketogenic diets may help reduce inflammation. However, no randomized controlled trials have investigated the effect of a diet on inflammatory markers in females with lipedema. To compare changes fibrosis-associated after low-energy (LCD) compared low-fat lipedema, to explore potential associations between pain markers. Females lipedema obesity were randomly assigned either LCD or (both 1200 kcal/d) for 8 weeks. Body composition [fat mass (FM) fat-free mass] plasma concentrations high-sensitivity C-reactive protein (hsCRP), cytokines, measured pre- postintervention. A total 70 included (35/group) (mean age: 47.3 ± 10.9 y, BMI: 36.9 4.9 kg/m2). Both groups lost weight FM (kg %), greater reduction group. macrophage protein-1ß, tumor necrosis factor-α, hsCRP was seen group only, despite significant differences groups. No found cytokines Changes did not differ beneficial profile Inflammation does seem be involved following this patient This trial registered at clinicaltrials.gov as NCT04632810.

Language: Английский

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Ketogenic Diets for Body Weight Loss: A Comparison with Other Diets

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 965 - 965

Published: March 10, 2025

With the prevalence of obesity and overweight increasing at an alarming rate, more researchers are focused on identifying effective weight loss strategies. The ketogenic diet (KD), used as a treatment in epilepsy management for over 100 years, is additionally gaining popularity method. Although its efficacy well documented, areas where it may be beneficial to other dietary approaches need carefully examined. objective this paper identify potential benefits KD alternative strategies based comprehensive literature review. It has been shown that bioenergetically efficient than strategies, inter alia owing effect curtailing hunger, improving satiety decreasing appetite (influence hunger hormones sensation hunger), inducing faster initial (associated with lower glycogen levels reduced water retention), controlling glycaemia insulinemia (directly attributable low-carbohydrate nature indirectly described). These effects accompanied by improved insulin sensitivity, inflammation (through ketone bodies avoidance pro-inflammatory sugars), pharmacological control (the diet’s mechanisms similar those medication but without side effects), positive impacts psychological factors food addiction. Based authors’ review latest research, reasonable conclude that, due these many additional health benefits, advantageous diet-based This important hypothesis deserves further exploration, which could achieved including outcome measures future clinical trials, especially when comparing different diets equal caloric value.

Language: Английский

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Impact of Dietary Fiber on Inflammation in Humans

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2000 - 2000

Published: Feb. 25, 2025

Cohort studies consistently show that a high intake of cereal fiber and whole-grain products is associated with decreased risk type 2 diabetes (T2DM), cancer, cardiovascular diseases. Similar findings are also reported for infectious chronic inflammatory disorders. All these disorders at least partially caused by inflammaging, state inflammation aging Metabolic Syndrome. Surprisingly, insoluble (cereal) shows stronger protective associations most long-term health outcomes than soluble fiber. Most humans consume mainly from sweet fruits, which usually come levels sugar, counteracting the potentially beneficial effects In both observational interventional studies, high-fiber diets impact on inflammation, can be attributed to variety nutrients apart dietary These confounders need considered when evaluating as part complex patterns. When assessing specific types fiber, inulin resistant starch clearly elicit anti-inflammatory short-term effects, while results pectins, beta-glucans, or psyllium turn out less convincing. For promising but sparse data have been published so far. Hypotheses putative mechanisms include direct immune cells (e.g., pectin), fermentation pleiotropic short-chain fatty acids (for fermentable only), modulation gut microbiome towards higher diversity, changes in bile acid metabolism, differential release hormones (such glucose-dependent insulinotropic peptide (GIP)), an improvement insulin resistance via mTOR/S6K1 signaling cascade. Moreover, contribution phytate-mediated antioxidative immune-modulatory means action needs considered. this review, we summarize present knowledge fiber-rich human system. However, given huge heterogeneity study designs, cohorts, interventions, outcomes, definite conclusions recommend whom cannot yet drawn.

Language: Английский

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Advances in Diet and Physical Activity in Breast Cancer Prevention and Treatment

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2262 - 2262

Published: July 13, 2024

There is currently a growing interest in diets and physical activity patterns that may be beneficial preventing treating breast cancer (BC). Mounting evidence indicates indeed, the so-called Mediterranean diet (MedDiet) regular likely both help reduce risk of developing BC. For those who have already received BC diagnosis, these interventions decrease tumor recurrence after treatment improve quality life. Studies also show potential other dietary interventions, including fasting or modified fasting, calorie restriction, ketogenic diets, vegan plant-based to enhance efficacy therapies. In this review article, we discuss biological rationale for utilizing prevention treatment. We highlight published ongoing clinical studies applied lifestyle patients. This offers valuable insights into application as complimentary therapies management.

Language: Английский

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The Ketogenic Diet as a Transdiagnostic Treatment for Neuropsychiatric Disorders: Mechanisms and Clinical Outcomes

Current Treatment Options in Psychiatry, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 21, 2024

This review explores the evidence for using a ketogenic diet as transdiagnostic treatment mental health disorders. We examine biological pathophysiologic mechanisms that underlie many neuropsychiatric disorders—such mitochondrial dysfunction, oxidative stress, inflammation, glucose hypometabolism, and glutamate/GABA imbalance—that can be ameliorated by diet. Additionally, literature summarizes clinical trials case reports on various psychiatric Recent research provides may an effective schizophrenia/schizoaffective disorder, bipolar depression, anxiety disorders, Alzheimer's disease, autism spectrum somatic eating alcohol use disorder. Many disorders have shared metabolic pathways exacerbate or cause psychopathology. The is not only address but also ameliorate symptoms like anxiety, mania, psychosis, cognitive impairment. These effects suggest has potential to serve non-pharmacological option ease global disease burden of

Language: Английский

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Examining the role of physical activity in older adults with epilepsy

Epilepsy & Behavior Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100756 - 100756

Published: Feb. 1, 2025

Language: Английский

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Nutritional Support of Chronic Obstructive Pulmonary Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1149 - 1149

Published: March 26, 2025

Background: COPD is a heterogenous disease of the respiratory tract caused by diverse genetic factors along with environmental and lifestyle-related effects such as industrial dust inhalation and, most frequently, cigarette smoking. These lead to airflow obstruction chronic symptoms. Additionally, increased risk infections exacerbates airway inflammation in patients. As consequence complex pathomechanisms difficulty treatment, among leading causes mortality both western countries developing world. Results: The management still challenge for clinicians; however, alternative interventions smoking cessation lifestyle changes from sedentary life moderate physical activity special attention diet may ameliorate patients' health. Here, we reviewed different dietary components supplements on conditions COPD. Conclusions: patients are continuously exposed heavy metals, which commonly present smoke polluted air. Meanwhile, they often experience significant nutrient deficiencies, affect detoxification these toxic metals. This turn can further disrupt nutritional balance interfering absorption, metabolism, utilization essential micronutrients. Therefore, awareness deliberate efforts should be made check levels micronutrients, ensuring adequate antioxidants, vitamin D, K2, magnesium, iron, particularly important reducing development limiting severity.

Language: Английский

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Status Epilepticus and Refractory Status Epilepticus

Published: Jan. 1, 2025

Language: Английский

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Remission of OCD and ulcerative colitis with a ketogenic diet: Case Report

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

There is little research describing the clinical use of a ketogenic diet in obsessive-compulsive disorder (OCD) or inflammatory bowel disease. We describe first application adult OCD with ulcerative colitis (UC) resulting complete remission OCD, UC, and improved metabolic health. A 37-year-old obese woman longstanding was treated for 12 weeks personalized whole-food (KMT 1:5:1 ratio) specialized psychiatry clinic. Adherence assessed by capillary beta-hydroxybutyrate (BHB) photojournaling food intake. Remission Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Florida Inventory scale (FOCI), Clinical Global Impression-Improvement/Severity (CGI-S/I). Patient Health Questionnaire-9 (PHQ-9) Yale Food Addictions 2.0 (YFAS 2.0) depression addiction. UC Partial Mayo Score (PMS) Ulcerative Colitis Patient-Reported Outcome (UC-PRO). Metabolic health laboratories bioimpedance. Quality life using validated scales flourishing, resilience, self-compassion, subjective narrative. occurred within 3 (PMS 0, UC-PRO 0). Progressive improvement inversely related to oscillating BHB, FOCI 0 at 9 weeks, (Y-BOCS CGI-S 1). Body weight decreased 12.2%, significant decreases percentage body fat visceral fat. Flourishing, self-compassion 2- 20-fold. Complete marked well-formulated ratio 1:5:1) meaningful positive impact on quality improvements self-compassion.

Language: Английский

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The effect of low-carbohydrate diets, based on changes in intake of dietary saturated fats on circulating TNF-α and interleukin- 6 levels in adults: a systematic review and meta-analysis of randomized controlled trials

BMC Nutrition, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 14, 2025

Low-carbohydrate diets (LCDs) have been associated with inflammation while there is still conflicting evidence regarding the effects of this type diet on inflammatory markers and clinical benefit them remains uncertain. So, we aimed to ascertain LCDs serum concentrations tumor necrosis factor alpha (TNF-α) interleukin- 6 (IL- 6) by performing a systematic review meta-analysis randomized trials (RCTs). The online databases PubMed, Cochrane Central Register Controlled Trials (CENTRAL), EMBASE, Web Science, Scopus were comprehensively searched up February 2024, find pertinent RCTs. Pooled weighted mean difference (WMD) 95% confidence intervals (CIs) calculated using random-effects model. This 33 studies assessed total 2106 adults irrespective their health status. Compared control group, participants experienced decline in IL- levels (WMD: - 0.31 pg/mL; CI: 0.49 0.12; P = 0.001). However, no significant effect was revealed for TNF-α 0.02 0.08 0.03; 0.449). Stratification analyses indicated that beneficial cytokines 0.28 0.47 0.10; 0.003, WMD: 0.26 0.48 0.027, 6, respectively) stronger when carbohydrate intake < 10%. results Meta-regression suggested baseline level both remained as strong predictor size (P 0.038 0.001 respectively). Adherence appeared be effective at improving particularly, restricted less than 10% energy. Nevertheless, further rigorously designed considering factors such race genetic, sources quality dietary carbohydrates, protein, fat are required gain deeper understanding impact markers. PROSPERO, registration no: CRD42023387452.

Language: Английский

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