Post-traumatic stress disorder and metabolic syndrome: the role of some antioxidants in treatment DOI Creative Commons
Victoria Serhiyenko, A.Yu. Oliinyk, Yaroslav Pavlovskyi

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2024, Volume and Issue: 20(6), P. 470 - 480

Published: Nov. 9, 2024

The basis for the pathogenesis of cardiovascular, cancer, metabolic diseases, low-grade chronic inflammation (LGCI) and many other disorders is an imbalance between prooxidants antioxidant defense system. It believed that link post-traumatic stress disorder (PTSD) syndrome (MetS) based on oxidative (OS), increased autonomic nervous system activity, glucocorticoid synthesis activation, or immunological dysregulation. Moreover, pathophysiological changes in systemic LGCI pathways result from modifications receptor reactivity (secondary to emotional physiological arousal) may be inappropriate social behavior consistent with PTSD MetS manifestations. Recently, evidence has emerged suggesting a combination high levels OS activation plays important role PTSD. On hand, type recurrent long-term trauma exacerbates accele­rates cellular aging. accompanied by release reactive oxygen nitrogen species, proinflammatory cytokines, biologically active substances cause OS. purpose this review was discuss individual antioxidants, particular polyphenols, flavonoids, carotenoids, N-acetylcysteine, melatonin, L-arginine, C E vitamins, zinc, copper, selenium, prevention/treatment comorbid pathology MetS, as well analyze new trends directions future research. search conducted Scopus, Science Direct (from Else­vier) PubMed, including MEDLINE databases. keywords used were “post-traumatic disorder,” “metabolic syndrome,” “antioxidants.” To identify research results could not found during online search, manual bibliography publications used.

Language: Английский

Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

Citations

1
Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer’s disease DOI Creative Commons
Ali Azargoonjahromi

Molecular Brain, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 18, 2024

Abstract Research on serotonin reveals a lack of consensus regarding its role in brain volume, especially concerning biomarkers linked to neurogenesis and neuroplasticity, such as ciliary neurotrophic factor (CNTF), fibroblast growth 4 (FGF-4), bone morphogenetic protein 6 (BMP-6), matrix metalloproteinase-1 (MMP-1) Alzheimer’s disease (AD). This study aimed investigate the influence structure hippocampal volumes relation cognitive functions AD, well link with like CNTF, FGF-4, BMP-6, MMP-1. Data from 133 ADNI participants AD included assessments (CDR-SB), measurements (Biocrates AbsoluteIDQ p180 kit, UPLC-MS/MS), factors quantified via multiplex proteomics. Gray matter volume changes were analyzed using Voxel-Based Morphometry (VBM) MRI. Statistical analyses employed Pearson correlation, bootstrap methods, FDR-adjusted p-values (< 0.05 or < 0.01) Benjamini–Hochberg procedure, alongside nonparametric methods. The analysis found positive correlation between levels total (r = 0.229, p 0.023) (right: r 0.186, 0.032; left: 0.210, 0.023), even after FDR adjustment. Higher better function (negative CDR-SB, −0.230, 0.024). Notably, positively correlated BMP-6 0.173, 0.047), CNTF 0.216, 0.013), FGF-4 0.176, 0.043), MMP-1 0.202, 0.019), suggesting neuroplasticity. However, adjusting for multiple comparisons controlling confounding age, gender, education, APOE genotypes (APOE3 APOE4), none correlations remained statistically significant. In conclusion, increased are associated improved volume. associations not significant adjustments, highlighting complexity serotonin’s need further research. Graphical

Language: Английский

Citations

4
Therapeutic effects of resveratrol on memory deficits in offspring of sleep-deprived rats: Involvement of hippocampal BDNF-TrkB pathways DOI
Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani, Maryam Farahmandfar, Mohammad‐Reza Zarrindast

et al.

Journal of Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Background: Maternal sleep deprivation (MSD) is a significant public health issue that adversely affects neurogenesis and synaptic plasticity in offspring, resulting cognitive deficits learning memory. Resveratrol, an antioxidant with neuroprotective anti-inflammatory properties, may help mitigate these effects. This study investigates resveratrol’s potential to counteract the negative impacts of MSD on neurodevelopment male Wistar rat offspring. Methods: Ninety-six offspring 36 pregnant rats were used. Total was induced using water box device gestational days 7, 11, 17. Pregnant received resveratrol at doses 25 or 50 mg/kg every 12 h during period. After parturition, divided into groups for assessment two months age. Social interaction tests evaluated social memory, while Morris maze test assessed spatial Brain samples prepared Nissl staining, brain-derived neurotrophic factor (BDNF) tyrosine-protein kinase (TrkB) expression levels hippocampus measured western blotting. Results: Our findings indicate group exhibited decreased BDNF/TrkB increased neuronal damage hippocampus, which led disrupted memory compared control group. Subsequently, administration, especially dose pregnancy, significantly reversed MSD’s detrimental effects function Conclusion: results provide novel evidence pregnancy models MSD, suggesting its developing therapeutic interventions targeting prenatal neurodegenerative disorders.

Language: Английский

Citations

0
Plasma tryptophan levels are linked to hippocampal integrity and cognitive function in individuals with mild cognitive impairment DOI
Ali Azargoonjahromi

Brain Imaging and Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Post-traumatic stress disorder and metabolic syndrome: the role of some antioxidants in treatment DOI Creative Commons
Victoria Serhiyenko, A.Yu. Oliinyk, Yaroslav Pavlovskyi

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2024, Volume and Issue: 20(6), P. 470 - 480

Published: Nov. 9, 2024

The basis for the pathogenesis of cardiovascular, cancer, metabolic diseases, low-grade chronic inflammation (LGCI) and many other disorders is an imbalance between prooxidants antioxidant defense system. It believed that link post-traumatic stress disorder (PTSD) syndrome (MetS) based on oxidative (OS), increased autonomic nervous system activity, glucocorticoid synthesis activation, or immunological dysregulation. Moreover, pathophysiological changes in systemic LGCI pathways result from modifications receptor reactivity (secondary to emotional physiological arousal) may be inappropriate social behavior consistent with PTSD MetS manifestations. Recently, evidence has emerged suggesting a combination high levels OS activation plays important role PTSD. On hand, type recurrent long-term trauma exacerbates accele­rates cellular aging. accompanied by release reactive oxygen nitrogen species, proinflammatory cytokines, biologically active substances cause OS. purpose this review was discuss individual antioxidants, particular polyphenols, flavonoids, carotenoids, N-acetylcysteine, melatonin, L-arginine, C E vitamins, zinc, copper, selenium, prevention/treatment comorbid pathology MetS, as well analyze new trends directions future research. search conducted Scopus, Science Direct (from Else­vier) PubMed, including MEDLINE databases. keywords used were “post-traumatic disorder,” “metabolic syndrome,” “antioxidants.” To identify research results could not found during online search, manual bibliography publications used.

Language: Английский

Citations

3