Role of diet in type 2 diabetes incidence: umbrella review of meta-analyses of prospective observational studies

BMJ, Journal Year: 2019, Volume and Issue: unknown, P. l2368 - l2368

Published: July 3, 2019

Abstract Objective To summarise the evidence of associations between dietary factors and incidence type 2 diabetes to evaluate strength validity these associations. Design Umbrella review systematic reviews with meta-analyses prospective observational studies. Data sources PubMed, Web Science, Embase, searched up August 2018. Eligibility criteria Systematic reporting summary risk estimates for behaviours or diet quality indices, food groups, foods, beverages, alcoholic macronutrients, micronutrients. Results 53 publications were included, 153 adjusted hazard ratios on indices (n=12), groups foods (n=56), beverages (n=10), macronutrients (n=32), micronutrients (n=31), regarding diabetes. Methodological was high 75% (n=115) meta-analyses, moderate 23% (n=35), low 2% (n=3). Quality rated an inverse association increased intake whole grains (for increment 30 g/day, ratio 0.87 (95% confidence interval 0.82 0.93)) cereal fibre 10 0.75 (0.65 0.86)), as well total alcohol 12-24 g/day v no consumption, (0.67 0.83)). also higher red meat 100 1.17 (1.08 1.26)), processed 50 1.37 (1.22 1.54)), bacon (per two slices/day, 2.07 (1.40 3.05)), sugar sweetened increase one serving/day, 1.26 (1.11 1.43)). Conclusions Overall, has been extensively studied, but few graded evidence. Further are likely be important in prevention; thus, more conducted research, detailed assessment diet, is needed. registration PROSPERO CRD42018088106.

Language: Английский

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Coffee, Caffeine, and Health

New England Journal of Medicine, Journal Year: 2020, Volume and Issue: 383(4), P. 369 - 378

Published: July 22, 2020

In many countries, a large majority of adults consume caffeine daily. This review summarizes the evidence about varied physiological effects and coffee risks cardiovascular disease, insulin resistance, gallstones, cancer, liver disease.

Language: Английский

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A Narrative Review on Sarcopenia in Type 2 Diabetes Mellitus: Prevalence and Associated Factors

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 183 - 183

Published: Jan. 9, 2021

Type 2 diabetes mellitus (T2DM) represents a major health burden for the elderly population, affecting approximately 25% of people over age 65 years. This percentage is expected to increase dramatically in next decades relation increased longevity population observed recent Beyond microvascular and macrovascular complications, sarcopenia has been described as new complication population. Increasing attention paid by researchers clinicians this age-related condition—characterized loss skeletal muscle mass together with power function—in individuals T2DM; due heavy impact that may have on physical psychosocial diabetic patients, thus their quality life. The aim narrative review provide an update on: (1) risk T2DM, (2) its association relevant features patients T2DM such age, gender, body index, disease duration, glycemic control, presence or nutritional status, glucose-lowering drugs. From clinical point view, it necessary improve ability physicians dietitians recognize early factors order make appropriate therapeutic approaches able prevent treat condition.

Language: Английский

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An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study

Diabetologia, Journal Year: 2020, Volume and Issue: 63(11), P. 2359 - 2371

Published: Sept. 7, 2020

The aim of this study was to use Mendelian randomisation (MR) identify the causal risk factors for type 2 diabetes.We first conducted a review meta-analyses and articles pinpoint possible diabetes. Around 170 were identified which 97 with available genetic instrumental variables included in MR analyses. To reveal more that not our analyses, we published studies For used summary-level data from DIAbetes Genetics Replication And Meta-analysis consortium (74,124 diabetes cases 824,006 controls European ancestry). Potential associations replicated using FinnGen (11,006 82,655 inverse-variance weighted method as main analysis. Multivariable analysis assess whether observed mediated by BMI. We Benjamini-Hochberg false discovery rate multiple testing.We found evidence between 34 exposures (19 15 protective factors) Insomnia novel factor (OR 1.17 [95% CI 1.11, 1.23]). other 18 depression, systolic BP, smoking initiation, lifetime smoking, coffee (caffeine) consumption, plasma isoleucine, valine leucine, liver alanine aminotransferase, childhood adulthood BMI, body fat percentage, visceral mass, resting heart rate, four fatty acids. associated decreased alanine, HDL- total cholesterol, age at menarche, testosterone levels, sex hormone binding globulin levels (adjusted BMI), birthweight, height, lean mass (for women), acids, circulating 25-hydroxyvitamin D education years. Eight remained after adjustment additionally 21 suggestive (p < 0.05), such alcohol breakfast skipping, daytime napping, short sleep, urinary sodium, certain amino acids inflammatory factors.The present verified several previously reported potential Prevention strategies should be considered perspectives on obesity, mental health, sleep quality, level, birthweight smoking.

Language: Английский

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Caffeine Consumption through Coffee: Content in the Beverage, Metabolism, Health Benefits and Risks

Beverages, Journal Year: 2019, Volume and Issue: 5(2), P. 37 - 37

Published: June 1, 2019

Caffeine (1,3,7-trimethylxanthine) is the most consumed psychoactive substance in world, acting by means of antagonism to adenosine receptors, mainly A1 and A2A. Coffee main natural source alkaloid which quite soluble well extracted during brew’s preparation. After consumption, caffeine almost completely absorbed extensively metabolized liver phase I (cytochrome P450) enzymes, CYP1A2, appears be polymorphically distributed human populations. Paraxanthine major metabolite plasma, while methylated xanthines methyluric acids are metabolites excreted urine. In addition stimulating central nervous system, exerts positive effects body, often association with other substances, contributing prevention several chronic diseases. The potential adverse have also been studied animal species humans. These aspects will approached present review.

Language: Английский

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Consumption of coffee and tea and risk of developing stroke, dementia, and poststroke dementia: A cohort study in the UK Biobank

PLoS Medicine, Journal Year: 2021, Volume and Issue: 18(11), P. e1003830 - e1003830

Published: Nov. 16, 2021

Background Previous studies have revealed the involvement of coffee and tea in development stroke dementia. However, little is known about association between combination risk stroke, dementia, poststroke Therefore, we aimed to investigate associations separately with developing Methods findings This prospective cohort study included 365,682 participants (50 74 years old) from UK Biobank. Participants joined 2006 2010 were followed up until 2020. We used Cox proportional hazards models estimate coffee/tea consumption incident adjusting for sex, age, ethnicity, qualification, income, body mass index (BMI), physical activity, alcohol status, smoking diet pattern, sugar-sweetened beverages, high-density lipoprotein (HDL), low-density (LDL), history cancer, diabetes, cardiovascular arterial disease (CAD), hypertension. Coffee was assessed at baseline. During a median follow-up 11.4 new onset disease, 5,079 developed 10,053 stroke. The dementia nonlinear ( P <0.01), intake 2 3 cups/d or 5 their 4 6 linked lowest hazard ratio (HR) Compared those who did not drink coffee, drinking cups per day associated 32% (HR 0.68, 95% CI, 0.59 0.79; < 0.001) lower 28% (HR, 0.72, 0.89; = 0.002) Moreover, ischemic vascular Additionally, daily level 0.52, 0.32 0.83; 0.007). main limitations that self-reported baseline may reflect long-term patterns, unmeasured confounders observational result biased effect estimates, Biobank are representative whole United Kingdom population. Conclusions found Intake alone

Language: Английский

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Coffee and tea on cardiovascular disease (CVD) prevention

Trends in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 32(7), P. 399 - 405

Published: Aug. 9, 2021

Language: Английский

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Consumers’ Perceptions of Coffee Health Benefits and Motives for Coffee Consumption and Purchasing

Nutrients, Journal Year: 2019, Volume and Issue: 11(3), P. 653 - 653

Published: March 18, 2019

Coffee is popular worldwide and consumption increasing, particularly in non-traditional markets. There evidence that coffee may have beneficial health effects. Consumers' beliefs the benefits of are unclear. The study aimed at analyzing consumers' perceptions benefits, purchasing motives consumers with positive willingness to pay for associated claims. Data were collected through a face-to-face survey consumers, resulting convenience sample 250 questionnaires valid data elaboration. Results elaborated factor analysis logistic regression analysis. Findings revealed relevant minority believed could consumer perception mostly male, young, works, familiar non-espresso-based coffee, consumes limited amount (generally not breakfast often social settings), buys retail outlets. Consumers drink its energetic therapeutic still price-driven, but interested opportunity improve minds.

Language: Английский

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Coffee consumption and all-cause and cause-specific mortality: a meta-analysis by potential modifiers

European Journal of Epidemiology, Journal Year: 2019, Volume and Issue: 34(8), P. 731 - 752

Published: May 4, 2019

Language: Английский

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Etiology and Pathogenesis of Latent Autoimmune Diabetes in Adults (LADA) Compared to Type 2 Diabetes

Frontiers in Physiology, Journal Year: 2019, Volume and Issue: 10

Published: March 26, 2019

As the heterogeneity of diabetes is becoming increasingly clear, opportunities arise for more accurate assessment factors influencing disease onset, which may lead to efficient primary prevention. LADA - latent autoimmune in adults a common, hybrid form with features both type 1 and 2 diabetes. This review aims summarize current knowledge on pathophysiological etiological overlap differences between diabetes, discuss similarities point at future research needs. Studies conducted date show clear genetic high risk conferred by variants human leukocyte antigen (HLA) region. In contrast, data from limited number studies lifestyle available indicate that share several environmental including overweight, physical inactivity, alcohol consumption (protective) smoking. These are known influence insulin sensitivity, suggesting resistance, addition deficiency due destruction beta cells, play key role pathogenesis LADA. Moreover, this implies onset LADA, similar some extent could be prevented or postponed modification such as weight reduction increased activity. The preventive potential an important topic elucidate studies, preferably intervention studies.

Language: Английский

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