Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 457 - 463
Published: Jan. 1, 2024
Language: Английский
World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(5), P. 800 - 814
Published: Feb. 2, 2023
Since the first identification in December of 2019 and fast spread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, it has represented a dramatic global public health concern. Though affecting mainly system, SARS-CoV-2 disease, defined as disease (COVID-19), may have systemic involvement leading to multiple organ dysfunction. Experimental evidence about tropism for liver increasing hepatic cytolysis enzymes during infection support presence pathophysiological relationship between SARS-CoV-2. On other side, patients with chronic been demonstrated poor prognosis COVID-19. In particular, cirrhosis appear extremely vulnerable infection. Moreover, etiology vaccination status could affect COVID-19 outcomes. This review analyzes impact stage related causes on morbidity mortality, clinical outcomes well efficacy disease.
Language: Английский
Citations
8
Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10
Published: March 24, 2023
The COVID-19 pandemic is ongoing and places a substantial burden on healthcare systems worldwide. As we further shed light different disease characteristics, identify more groups of people at higher risk poor outcomes. Metabolic-associated fatty liver (MAFLD) (previously non-alcoholic or NAFLD) common metabolic disorder characterized by fat accumulation fibrosis. Given its close correlation with syndrome, an established factor for severe COVID-19, it necessary to investigate interplay the novel coronavirus. In this study, review available data prognosis, treatment prevention options in patients MAFLD, effect that have MAFLD care. Furthermore, point out gaps current literature accentuate work needs be done improve care during beyond.
Language: Английский
Citations
8
Hormone and Metabolic Research, Journal Year: 2022, Volume and Issue: 54(08), P. 522 - 531
Published: April 25, 2022
Abstract Coronavirus disease 2019 (COVID-19) is characterized by a wide clinical spectrum that includes abnormalities in liver function indicative of damage. Conversely, people with diseases are at higher risk severe COVID-19. In the current review, we summarize first epidemiologic evidence describing bidirectional relationship between COVID-19 and function/liver diseases. Additionally, present most frequent histologic findings as well important direct indirect mechanisms supporting mediated injury. Furthermore, focus on general population, non-alcoholic or metabolic-associated fatty (NAFLD/MAFLD), describe how may affect NAFLD/MAFLD development progression conversely further aggravate infection. Finally, long-term consequences pandemic management NAFLD.
Language: Английский
Citations
14
World Journal of Virology, Journal Year: 2023, Volume and Issue: 12(1), P. 30 - 43
Published: Jan. 17, 2023
Coronavirus disease 2019 (COVID-19) has affected patients with pre-existing chronic liver (CLD) in various ways. The maximum impact was seen on underlying cirrhosis who have shown to poor clinical outcomes the form of increased risk hepatic decompensation, acute-on-chronic failure, and even mortality. It is paramount importance identify factors which are associated unfavorable for prognostication making informed management strategy. Many been evaluated different studies CLD. Some these include severity disease, comorbid conditions, age, COVID-19. Overall, not fav-orable as evidenced by data from studies. main purpose this review predictors adverse including mortality CLD stratification, prognostication, appropriate management.
Language: Английский
Citations
7
Microorganisms, Journal Year: 2023, Volume and Issue: 11(6), P. 1571 - 1571
Published: June 13, 2023
Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic in Western countries, has been identified as a possible risk factor for COVID-19 severity. However, immunological mechanisms by which NAFLD exacerbates remain unknown. Transforming growth factor-beta 1 (TGF-β1) an important immunomodulatory and pro-fibrotic role, already described NAFLD. role TGF-β1 remains unclear, could also be pathophysiology link between these two conditions. The aim this case–control study was to analyze expression patients depending on presence Serum concentrations were measured 60 hospitalized (30 with NAFLD). associated higher serum that increased Admission showed good discriminative accuracy predicting development critical complications (need advanced respiratory support, ICU admission, time recovery, nosocomial infections mortality). In conclusion, efficient biomarker severity adverse outcomes
Language: Английский
Citations
7
Life, Journal Year: 2022, Volume and Issue: 13(1), P. 36 - 36
Published: Dec. 23, 2022
Community-acquired pneumonia (CAP) is one of the leading causes morbidity and mortality, while nonalcoholic fatty liver disease (NAFLD) most common cause chronic disease. NAFLD associated with systemic changes in immune response, possibly linked to CAP severity. However, impact on outcomes has not been determined. The aim this study was evaluate clinical course, complications severe requiring ICU treatment patients pre-COVID-19 era. A retrospective cohort included 138 consecutively hospitalized adult admitted during a 4-year period: 80 58 controls. Patients more frequently presented ARDS (68.7% vs. 43.1%), required invasive mechanical ventilation (86.2% 63.8%), respiratory ECMO (50% 24.1%), continuous renal replacement therapy (62.5% 29.3%). Mortality significantly higher group 20.7%), time from hospital admission death shorter. In survival analysis, (HR 2.21, 95%CI 1.03-5.06) mortality independently other components metabolic syndrome. conclusion, our identified as an independent predictor CAP.
Language: Английский
Citations
12
World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(21), P. 3362 - 3378
Published: May 30, 2023
Non-alcoholic fatty liver disease (NAFLD) and metabolic-associated (MAFLD) are on the rise like any other disease, tend to affect 25% of United States population. The impact NAFLD MAFLD patients with coronavirus 2019 (COVID-19) remains unclear.To identify association mortality, hospitalization, hospital length stay, supplemental oxygen utilization in COVID-19 patients.A systematic review literature Cochrane, Embase, PubMed, ScienceDirect, Web Science databases was conducted from January July 2022. Studies that evaluated NAFLD/MAFLD using laboratory methods, noninvasive imaging, or biopsy were included. study protocol registered PROSPERO (ID CRD42022313259) PRISMA guidelines followed. National Institutes Health quality assessment tool used assess studies. Pooled analysis software Rev Man version 5.3. stability results assessed sensitivity analysis.Thirty-two studies 43388 included meta-analysis whom 8538 (20%) observed have NAFLD. There 42254 28 mortality analysis. A total 2008 died COVID-19; 837 (10.52%) group 1171 (3.41%) non-NAFLD group. odds ratio (OR) 1.38 for a 95% confidence interval (95%CI) = 0.97-1.95 P 0.07. 5043 eight stay 1318 3725 qualitative synthesis showed mean difference about 2 d between groups 95%CI 0.71-3.27 0.002. For hospitalization rates, OR 3.25 1.73-6.10 0.0002. utilization, 2.04 1.17-3.53 0.01.Our suggests there increased longer use patients.
Language: Английский
Citations
5
Egyptian Journal of Medical Human Genetics, Journal Year: 2023, Volume and Issue: 24(1)
Published: Aug. 29, 2023
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic showing a rising prevalence globally. Genetic predisposition plays key role in development and progression of pathogenicity. Main body This paper summarizes genetic associations based on their influence several metabolic aspects such as lipid metabolism, glucose hepatic iron accumulation cholesterol metabolism toward NAFLD Furthermore, we present variations some epigenetic characters microRNA profile with regard to NAFLD. Conclusion As reported many studies, PNPLA3 rs738409 variant seems be significantly associated susceptibility. Other gene variants like TM6SF2 rs58542926, MBOAT7 rs641738 GCKR also appear more prevalent among patients. We believe these may provide insights into new trends developing noninvasive biomarkers identify suitability clinical practice future. Graphical abstract
Language: Английский
Citations
5
EBioMedicine, Journal Year: 2023, Volume and Issue: 99, P. 104912 - 104912
Published: Dec. 13, 2023
Abnormal liver function was frequently observed in nonalcoholic fatty disease (NAFLD) patients infected with SARS-CoV-2. Our aim to explore the effect of SARS-CoV-2 inactivated vaccines on abnormality among NAFLD COVID-19.
Language: Английский
Citations
4
Journal of Human Sciences and Extension, Journal Year: 2018, Volume and Issue: unknown
Published: May 14, 2018
A Health in All Policies approach engages cross-sector stakeholders to collaboratively improve systems that drive population health. We, the members of Extension Committee on Organization and Policy (ECOP)’s Action Team, propose adopting a within national Cooperative System will better prepare us contribute meaningfully improving nation’s We first explain argue for why how it is relevant Extension. then present insights gathered from Family Consumer Sciences program leaders state specialists assess whether leadership are poised adopt their affiliated programs. Although participant saw value contributing health improvement, they generally system as having lower levels readiness such an approach. Six themes emerged ways increase Extension’s engagement Policies: paradigm shift Extension, professional development competencies, transformational support, continued new partnerships, information access all disciplines
Language: Английский
Citations
7