Journal of Xenobiotics,
Journal Year:
2025,
Volume and Issue:
15(1), P. 32 - 32
Published: Feb. 17, 2025
Candida
infections
severely
impact
patients
who
are
immunocompromised.
Currently,
there
limited
options
to
treat
fungal
infections,
especially
drug-resistant-fungal
infections.
Therefore,
investigating
alternative
or
repurposed
antifungals
is
paramount.
Endophytic
microbes
(EMs)
and
rhizospheric
(RMs)
emerge
as
promising
reservoirs
of
bioactive
natural
compounds.
Interestingly,
plants
that
have
adapted
various
environmental
conditions
harbour
a
plethora
producing
variety
products
can
be
assessed
for
potential
antifungal
activity.
To
date,
EMs
RMs
residing
in
coastal
their
associated
not
been
extensively
studied
reviewed.
this
comprehensive
review
will
focus
on
products,
extracted
from
coastal-vegetation-associated
microbiota
draw
the
attention
research
field.
A
literature
search
was
conducted
by
examining
both
Scopus
Google
Scholar
databases
during
period
2013–2024
related
following
vegetation:
mangroves,
sand
dune
plants,
salt
marsh
seagrasses.
65
novel
compounds
derived
coastal-plant
identified.
Mangroves
were
found
most
prominent
host
harbouring
antifungal-producing
compared
with
other
plants.
Coastal-plant-associated
partners
producers
bacterial
counterparts.
Fifty-four
fungal-EM/RM
reported
demonstrate
activities
against
plant
pathogenic
fungi
well
human
pathogens.
Most
bacterial-derived
(11
antifungals)
previously
activity
albicans.
Molecular Aspects of Medicine,
Journal Year:
2023,
Volume and Issue:
94, P. 101215 - 101215
Published: Oct. 5, 2023
Invasive
fungal
diseases
are
common
complications
in
critically
ill
patients
and
those
with
significant
underlying
imbalanced
immune
systems.
Fungal
co-,
and/or
super-infections
emerging
have
become
a
rising
concern
within
the
last
few
years.
In
Europe,
cases
of
candidiasis
aspergillosis
dominate,
followed
by
mucormycosis
India.
Epidemiological
studies
show
an
increasing
trend
incidence
all
three
entities.
Parallel
to
this,
shift
pathogens
is
observed.
More
non-albicans
Candida
infections
cryptic
species
on
rise;
may
cover
intrinsic
resistance
azoles
other
antifungal
drugs.
The
recent
COVID-19
pandemic
led
significantly
invasive
among
hospitalized
patients.
Journal of Clinical Microbiology,
Journal Year:
2023,
Volume and Issue:
61(11)
Published: Oct. 26, 2023
The
rapid
pace
of
name
changes
medically
important
fungi
is
creating
challenges
for
clinical
laboratories
and
clinicians
involved
in
patient
care.
We
describe
two
sources
change
which
have
different
drivers,
at
the
species
versus
genus
level.
Some
suggestions
are
made
here
to
reduce
number
changes.
urge
taxonomists
provide
diagnostic
markers
taxonomic
novelties.
Given
instability
phylogenetic
trees
due
variable
taxon
sampling,
we
advocate
maintain
genera
largest
possible
size.
Reporting
identified
complexes
or
series
should
where
comprise
both
overarching
that
molecular
sibling,
often
cryptic
species.
Because
use
names
same
will
be
unavoidable
many
years
come,
an
open
access
online
database
all
fungi,
with
proper
nomenclatural
designation
synonymy,
essential.
further
recommend
while
discovery
continues,
adaptation
new
by
reviewed
routinely
a
standing
committee
validation
stability
over
time,
reference
database,
wherein
reasons
listed
transparent
way.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4775 - 4775
Published: April 27, 2024
Extracellular
proteases
are
key
factors
contributing
to
the
virulence
of
pathogenic
fungi
from
genus
Candida.
Their
proteolytic
activities
crucial
for
extracting
nutrients
external
environment,
degrading
host
defenses,
and
destabilizing
internal
balance
human
organism.
Currently,
enzymes
most
frequently
described
in
this
context
secreted
aspartic
(Saps).
This
review
comprehensively
explores
multifaceted
roles
Saps,
highlighting
their
importance
biofilm
formation,
tissue
invasion
through
degradation
extracellular
matrix
proteins
components
coagulation
cascade,
modulation
immune
responses
via
impairment
neutrophil
monocyte/macrophage
functions,
contribution
antifungal
resistance.
Additionally,
diagnostic
challenges
associated
with
Candida
infections
potential
Saps
as
biomarkers
were
discussed.
Furthermore,
we
examined
prospects
developing
vaccines
based
on
use
protease
inhibitors
adjunctive
therapies
candidiasis.
Given
complex
biology
central
role
pathogenicity,
a
multidisciplinary
approach
may
pave
way
innovative
strategies
open
new
opportunities
clinical
interventions
against
Diagnostics,
Journal Year:
2024,
Volume and Issue:
14(5), P. 520 - 520
Published: Feb. 29, 2024
The
world
has
seen
a
tremendous
increase
in
the
number
of
fungal
infections
during
past
two
decades.
Recently,
World
Health
Organisation
released
pathogen
priority
list
for
infections,
signifying
importance
these
fields
research
and
public
health.
Microbiology
laboratories
demand
an
upgrade
diagnostic
system
to
keep
up
with
increased
burden
infections.
Diagnosis
using
conventional
techniques
always
faced
limitations
terms
specificity,
sensitivity,
turnaround
time.
Although
methods
are
core
pillars
diagnosis,
there
is
need
molecular
approaches.
Molecular
have
revolutionised
field
diagnostics.
diverse
array
techniques,
including
like
Polymerase
Chain
Reaction
(PCR),
emerged
as
cornerstone
transformed
diagnostics,
providing
powerful
tools
rapid
accurate
identification
pathogens.
As
technologies
continue
evolve,
their
integration
into
routine
clinical
practice
holds
promise
improving
patient
outcomes
through
timely
targeted
antifungal
interventions.
This
review
will
cover
approaches
involved
moving
from
basic
advanced-level
nucleic-acid-based
high
throughput
decreased
time
diagnosis
serious
Therapeutic Advances in Infectious Disease,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
It
is
of
utmost
importance
to
monitor
any
change
in
the
epidemiology
fungal
diseases
that
may
arise
from
a
number
at-risk
population
or
availability
local
data.
JAC-Antimicrobial Resistance,
Journal Year:
2025,
Volume and Issue:
7(2)
Published: March 4, 2025
The
aim
of
this
study
was
to
identify
and
determine
the
MICs
13
antifungal
drugs,
including
novel
agents
ibrexafungerp,
manogepix
rezafungin,
against
22
laboratory
reference
strains
from
14
different
Candida
spp.
allied
yeast
genera
using
EUCAST,
CLSI
Sensititre™
YeastOne™
(SYO)
methods.
Complete
agreement
between
molecular
proteomics
methods
observed
for
identification.
compounds
with
greatest
in
vitro
activity,
as
indicated
by
lowest
geometric
mean
MIC
(GM),
were
(GM:
0.01),
isavuconazole
0.05)
rezafungin
0.03-0.07).
overall
essential
(EA)
(within
±0
±2
2-fold
dilutions)
methods,
EUCAST
CLSI,
95%,
results
ranging
82%
(ibrexafungerp)
100%
(amphotericin
B,
anidulafungin,
fluconazole,
5-flucytosine
micafungin).
Regarding
EA
compared
SYO,
values
91%
89%,
respectively.
Nevertheless,
when
transformed
into
log2,
significant
differences
(e.g.
ibrexafungerp
5-flucytosine).
At
species
level,
Candidozyma
auris
duobushaemulonii
exhibited
highest
number
cases
comparing
three
techniques
each
antifungal.
high
reinforces
reliability
SYO
guiding
therapy.
However,
EA,
particularly
5-flucytosine,
highlight
importance
continued
evaluation
these
methodologies
ensure
consistency.
Given
that
susceptibility
testing
plays
a
critical
role
treatment
decisions,
understanding
variations
is
prevent
potential
misclassification
profiles,
which
could
impact
clinical
outcomes.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
14
Published: Jan. 14, 2025
Candida
albicans
is
a
prevalent
fungal
pathogen
responsible
for
infections
in
humans.
As
described
recently,
nanometer-sized
extracellular
vesicles
(EVs)
produced
by
C.
play
crucial
role
the
pathogenesis
of
infection
facilitating
host
inflammatory
responses
and
intercellular
communication.
This
study
investigates
functional
properties
EVs
released
biofilms
formed
two
strains—3147
(ATCC
10231)
SC5314—in
eliciting
responses.
We
demonstrate
capability
to
trigger
reactions
human
epithelial
immune
cells.
The
involvement
was
evidenced
from
initial
stages
infection,
specifically
adherence
further
established
capacity
these
induce
cytokine
production
A549
cell
line,
THP-1
macrophage-like
cells,
blood-derived
monocytes
differentiated
into
macrophages.
Internalization
cells
confirmed,
identifying
macropinocytosis
phagocytosis
as
most
probable
mechanisms,
demonstrated
using
various
inhibitors
that
target
potential
vesicle
uptake
pathways
Additionally,
their
cargo
were
identified
chemoattractants
neutrophils.
After
verification
vivo
effect
biofilm-derived
on
host,
Galleria
mellonella
larvae
an
alternative
model,
it
SC5314
increased
mortality
injected
larvae.
In
conclusion,
both
types
predominantly
pro-inflammatory
observed,
highlighting
significant
response
during
infection.
Expert Review of Molecular Diagnostics,
Journal Year:
2023,
Volume and Issue:
23(12), P. 1135 - 1152
Published: Oct. 6, 2023
Invasive
fungal
infections
cause
millions
of
annually,
but
diagnosis
remains
challenging.
There
is
an
increased
need
for
low-cost,
easy
to
use,
highly
sensitive
and
specific
molecular
assays
that
can
differentiate
between
colonized
pathogenic
organisms
from
different
clinical
specimens.