A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

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Microbes Saving Lives and Reducing Suffering

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

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The Gut-Brain Axis and Neuroinflammation in Traumatic Brain Injury

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 62(4), P. 4576 - 4590

Published: Oct. 28, 2024

Language: Английский

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Beneficial Effects of Synbiotics on the Gut Microbiome in Individuals with Low Fiber Intake: Secondary Analysis of a Double-Blind, Randomized Controlled Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2082 - 2082

Published: June 29, 2024

Insufficient dietary fiber intake can negatively affect the intestinal microbiome and, over time, may result in gut dysbiosis, thus potentially harming overall health. This randomized controlled trial aimed to improve of individuals with low (<25 g/day) during a 7-week synbiotic intervention. The metabolically healthy male participants (n = 117, 32 ± 10 y, BMI 25.66 3.1 kg/m2) were divided into two groups: one receiving supplement (Biotic Junior, MensSana AG, Forchtenberg, Germany) and other placebo, without altering their habits or physical activity. These groups further stratified by group (LFG) high (HFG). Stool samples for analysis collected before after Statistical was performed using linear mixed effects partial least squares models. At baseline, microbiomes LFG HFG partially separated. After seven weeks intervention, abundance SCFA-producing microbes significantly increased LFG, which is known health; however, this effect less pronounced HFG. Beneficial on be achieved synbiotics, demonstrating importance personalized synbiotics.

Language: Английский

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Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 125 - 125

Published: Jan. 7, 2025

Background and Aims: Avolition is a symptom responsible for high burden in patients suffering from psychiatric diseases. It refers to motivation loss initiating maintaining goal-directed activities, often called fatigue by patients. Fatigue widespread complaint of inflammatory bowel disease (IBD), significantly impacting patients' well-being, even during the quiescent stage disease. We here address hypothesis that experienced IBD associated with motivational impairment. Methods: Patients presenting (n = 110) Crohn's (CD) 60) ulcerative colitis (UC) 50) were enrolled classified following their declared experience 58) or not 52). phenotyped using self-administered scales experience, disability, quality life mental health symptoms. Results: The negative symptoms scale scores identified avolition as specific feature experience: fatigued vs. no-fatigue CD group (3.806 2.103; p 0.003) UC (2.815 1.174; 0.003). This difference independent current depressive disorder previous history disorder. associates correlates (r 0.49) multivariate analysis. Conclusions: To tackle question IBD, research should consider investigating biological mechanisms implicating intestinal physiopathology impairment brain structure involved motivation. may open new fields treatment targeting structures reward system.

Language: Английский

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The Legalome: Microbiology, Omics and Criminal Justice

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(3)

Published: March 1, 2025

ABSTRACT Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles human cognition behaviour. Included this research is evidence indicating gut microbes, through direct indirect pathways, can influence aggression, anger, irritability antisocial Moreover, manufacture chemicals are known to compromise cognition. For example, recent court decisions United States Europe acknowledge produce high levels of ethanol, without consumption alcohol by defendants. The dismissal driving while intoxicated charges these cases—so‐called auto‐brewery syndrome—highlights way which microbiome knowledge will enhance precision, objectivity fairness our legal systems. Here opinion essay, we introduce concept ‘legalome’—the application science forensic psychiatry criminal law. We argue rapid pace microbial discoveries, including those challenge ideas free moral responsibility, necessitate a reconsideration traditional doctrines justifications retributive punishment. implications extend beyond courtroom, challenging us reconsider how environmental factors—from diet socioeconomic conditions—might shape preventative rehabilitative efforts their effects on microbiome.

Language: Английский

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Associations of Microbiome Pathophysiology with Social Activity and Behavior are Mediated by Epigenetic Modulations: Avenues for Designing Innovative Therapeutic Strategies

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106208 - 106208

Published: May 1, 2025

Language: Английский

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The Intersection of Ultra-Processed Foods, Neuropsychiatric Disorders, and Neurolaw: Implications for Criminal Justice

NeuroSci, Journal Year: 2024, Volume and Issue: 5(3), P. 354 - 377

Published: Sept. 23, 2024

Over the last decade there has been increasing interest in links between consumption of ultra-processed foods and various neuropsychiatric disorders, aggression, antisocial behavior. Neurolaw is an interdisciplinary field that seeks to translate rapid voluminous advances brain science into legal decisions policy. An enhanced understanding biophysiological mechanisms by which influence behavior allows for a historical reexamination one forensic neuropsychiatry's most famous cases-

Language: Английский

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The Legalome: Nutritional Psychology and Microbiome Sciences at the Intersection of Criminal Justice, Mens Rea, and Mitigation

Criminal Justice and Behavior, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Recent studies have linked ultra-processed foods with neuropsychiatric disorders, and behaviors of relevance to the criminal justice system. This nutritional epidemiology has been bolstered by mechanistic bench science, human intervention trials, addiction advances in microbiome research. Here, we examine this burgeoning research through lens diminished capacity intent. We use recent legal decisions related auto-brewery syndrome as a way illustrate how intersecting diet gut science is already finding its courtrooms. The legalome—microbiome omics applied forensic psychology—is emerging an important consideration for experts within field behavior. It our contention that are merely prelude ways which combination microbiology psychology will challenge basic assumptions free mens rea.

Language: Английский

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Dysbiose

Heilpflanzen, Journal Year: 2024, Volume and Issue: 04(04), P. 18 - 21

Published: Dec. 1, 2024

Milliarden von Lebewesen bevölkern den menschlichen Darm. Und das ist gut so. Ein gesundes Darmmikrobiom fördert Gesundheit und Wohlbefinden. Ungleichgewicht in seiner Zusammensetzung kann hingegen Beschwerden verursachen Krankheiten begünstigen.

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