Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 107 - 139
Published: Oct. 1, 2024
Language: Английский
Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(9), P. 241 - 241
Published: Aug. 23, 2024
The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity insufficient biological signaling. This review examines nanoparticles (NPs) in tissue engineering (TE) to address these challenges, evaluating polymers, metals, ceramics, composites their potential enhance osteogenesis angiogenesis by mimicking extracellular matrix (ECM) nanostructure. involved synthesizing characterizing nanoparticle-based scaffoldsand integrating hydroxyapatite (HAp) with polymers mechanical properties osteogenic potential. results showed that NPs significantly promote cell growth, differentiation, formation, carbon-based graphene carbon nanotubes showing promise. offer versatile, biocompatible, customizable scaffolds drug delivery support repair. Despite promising results, challenges cytotoxicity, biodistribution, immune responses remain. Addressing issues through surface modifications biocompatible molecules can improve biocompatibility efficacy nanomaterials. Future research should focus on long-term vivo studies assess safety NP-based explore synergistic effects other bioactive or growth factors. underscores transformative advancing BTE calls further optimize technologies clinical applications.
Language: Английский
Citations
11
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 60828 - 60841
Published: Oct. 24, 2024
Intracellular sensing technologies necessitate a delicate balance of spatial resolution, sensitivity, biocompatibility, and stability. While existing methods partially fulfill these criteria, none offer comprehensive solution. Nanodiamonds (NDs) harboring nitrogen-vacancy (NV) centers have emerged as promising candidates due to their capabilities under biological conditions ability meet all aforementioned requirements. This study focuses on expanding the application NDs NV center-based neuronal contexts by investigating functionalization subsequent effects three distinct cell lines relevant neurodegenerative disease research. Our concentrates positioning fluorescent (FNDs) with center point defects onto surfaces. Achieving this through specific antibody attachment enhances proximity FND neurites, facilitating detection local action potentials. Targeting voltage-dependent calcium channels (Cav2.2) biotin-streptavidin-bound antibodies enables precise FNDs. The functionalized FNDs (f-FNDs) show increased size zeta potential, confirming presence without compromising viability. Two-color confocal imaging co-localization algorithms are employed further attest success functionalization. f-FNDs applied cultures lines: SH-SY5Y, differentiated dopaminergic neurons, hippocampal rat neurons; biocompatibility synaptic activity explored. Moreover, preliminary total internal reflection fluorescence - optically detected magnetic resonance (TIRF-ODMR) experiments across cellular sites demonstrate field sensitivity our sensor network. successful establishment network provides platform for characterizing signaling in healthy models mimicking Parkinson's disease.
Language: Английский
Citations
4
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 227 - 239
Published: Jan. 1, 2025
Language: Английский
Citations
0
Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114313 - 114313
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 9, 2025
In this review, we explore the exciting potential of nanodiamonds (NDs) as innovative materials for future wound dressings. These aim to tackle important issues in care and offer fresh solutions. While NDs show promising mechanical structural properties, their full healing applications is still not fully explored. We emphasize unique features-like high surface area, dispersion functional groups, excellent purity-which contribute stability, adhesion, growth, movement-all critical effective tissue repair. also focused on modifying these particles using various functionalization, which can enhance biocompatibility, antibacterial heat conductivity, wettability. This positions a powerful tool improving chronic future. However, there are notable challenges when it comes scaling up ND-based nanofiber matrices, currently limits electrospinning process mass production. Also, with physical chemical stability nanofibers interacting cells need be resolved guarantee long-lasting effectiveness. study, by suggesting solutions like optimizing process, creating hybrid scaffolds. Our findings that innovations effectively address scalability issues, paving way broader clinical applications. review only emphasizes advantages but introduces new insights enhancing biocompatibility functionality nanofibers, finally pushing technology dressings forward.
Language: Английский
Citations
0
Green Processing and Synthesis, Journal Year: 2024, Volume and Issue: 13(1)
Published: Jan. 1, 2024
Abstract As carbon-based nanomaterials have such remarkable physical, chemical, and electrical capabilities, they become a major focus of materials science study. A thorough examination several carbon nanomaterial varieties, as nanotubes, graphene, fullerenes, nanodiamonds, is given in this review work. These all distinctive qualities that qualify them for particular uses. This work starts by examining the synthesis processes these nanomaterials, outlining ways which are made variables affecting their ultimate characteristics. The specific features each kind will then be briefly discussed study, along with size, structure, special physical chemical properties. wide range possible uses fields. They employed electronics industry to fabricate sensors, high-speed transistors, other devices. Their high surface area conductivity make useful energy storage devices like supercapacitors batteries. applied environmental remediation water purification science. biomedicine biosensing, bioimaging, medication delivery. Notwithstanding encouraging uses, large-scale functionalization present difficulties. discusses importance studying multifaceted properties potential applications industries. novelty lies its detailed degradation toxicity materials, essential safe integration into various technological biomedical applications. By thoroughly analysing recent experimental results, aims bridge gap between fundamental research practical
Language: Английский
Citations
1
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 107 - 139
Published: Oct. 1, 2024
Language: Английский
Citations
0