International Journal of Scientific Research in Science and Technology,
Journal Year:
2024,
Volume and Issue:
11(6), P. 826 - 840
Published: Dec. 27, 2024
The
integration
of
silver
nanoparticles
(AgNPs)
into
bone
cement
has
emerged
as
a
cutting-edge
approach
to
enhance
the
functional
properties
orthopedic
biomaterials.
Silver
nanoparticles,
known
for
their
broad-spectrum
antimicrobial
properties,
provide
an
innovative
solution
combat
implant-associated
infections.
This
review
delves
synthesis
methods,
including
in
situ
formation
and
physical
blending,
examines
performance
AgNP-infused
terms
efficacy,
mechanical
strength,
biocompatibility.
By
addressing
challenges
such
cytotoxicity
regulatory
considerations,
this
analysis
highlights
its
transformative
potential
reducing
infection
rates,
enhancing
implant
longevity,
ultimately
improving
patient
outcomes
surgeries.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(23), P. 3303 - 3303
Published: Nov. 26, 2024
Polymers
have
become
essential
in
advancing
bone
tissue
engineering,
providing
adaptable
healing
and
regeneration
solutions.
Their
biocompatibility
biodegradability
make
them
ideal
candidates
for
creating
scaffolds
that
mimic
the
body’s
natural
extracellular
matrix
(ECM).
However,
significant
challenges
remain,
including
degradation
by-products,
insufficient
mechanical
strength,
suboptimal
cellular
interactions.
This
article
addresses
these
by
evaluating
performance
of
polymers
like
poly(lactic-co-glycolic
acid)
(PLGA),
polycaprolactone
(PCL),
polylactic
acid
(PLA)
scaffold
development.
It
also
explores
recent
innovations,
such
as
intelligent
polymers,
bioprinting,
integration
bioactive
molecules
to
enhance
efficacy.
We
propose
overcoming
current
limitations
requires
a
combination
novel
biomaterials,
advanced
fabrication
techniques,
tailored
regulatory
strategies.
The
future
potential
polymer-based
personalised
regenerative
medicine
is
discussed,
focusing
on
their
clinical
applicability.
Materials Research Express,
Journal Year:
2025,
Volume and Issue:
12(1), P. 015405 - 015405
Published: Jan. 1, 2025
Abstract
Nanofibers
are
considered
promising
materials
for
tissue
engineering
applications
due
to
their
ability
promote
cell
adhesion
and
form
desired
environments
where
new
can
grow.
Furthermore,
we
evaluated
the
impact
of
increasing
concentration
(1–6
wt%)
HAp
on
morphology
subsequent
consequences
regarding
mechanical
properties,
wettability,
biodegradative
nature
wrinkle-free
PVA/collagen
nanofiber
scaffolds
fabricated
by
electrospinning.
FTIR
SEM
were
used
analyze
functional
groups
surface
observe
morphological
characteristics
those
particles.
revealed
that
when
was
enhanced,
a
finer
fiber
with
diameters
in
range
80–500
nm
obtained.
The
test
demonstrated
better
properties
composites
load.
In
addition,
water
contact
angle
decreased
(a
faster
degradation
rate),
which
consistent
higher
suitability
degradation.
Roughly
1.71
billion
people
worldwide
suffer
from
large
bone
abnormalities,
which
are
the
primary
cause
of
disability.
Traditional
grafting
procedures
have
several
drawbacks
that
impair
their
therapeutic
efficacy
and
restrict
use
in
clinical
settings.
A
great
deal
work
has
been
done
to
create
fresh,
more
potent
strategies.
Under
these
circumstances,
a
crucial
technique
for
regeneration
major
lesions
emerged:
tissue
engineering
(BTE).
BTE
involves
biomaterials
can
imitate
natural
design
bone.
To
yet,
no
biological
material
able
fully
meet
parameters
perfect
implantable
material,
even
though
varieties
created
investigated
regeneration.
Against
this
backdrop,
researchers
focused
interest
over
past
few
years
on
subject
nanotechnology
nanostructures
regenerative
medicine.
The
ability
nanoengineered
particles
overcome
current
constraints
strategies─such
as
decreased
cell
proliferation
differentiation,
insufficient
mechanical
strength
materials,
production
extrinsic
factors
required
effective
osteogenesis
revolutionized
field
engineering.
effects
nanoparticles
characteristics
application
materials
main
topics
our
review,
summarizes
most
recent
vitro
vivo
research
context
BTE.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(3), P. 109 - 109
Published: March 19, 2025
Background:
Oral
cancer
is
an
aggressive
malignancy
with
modest
survival
rates.
It
also
causes
disfigurement
following
surgical
removal
of
the
tumor,
thus
highlighting
need
for
new
treatment
and
tissue
repair
modalities.
Carbon-based
nanomaterials
have
emerged
as
promising
tools
in
both
anticancer
regenerative
therapies.
Objectives:
We
aimed
to
synthesize
a
carbon-based
nanomaterial
(CBN)
test
its
antineoplastic
effects,
well
potential
capacity.
Materials
Methods:
A
carbon
nanomaterial,
obtained
by
ball
milling
graphite
flakes,
was
functionalized
polyvinylpyrrolidone
(CBN/PVP).
Its
physicochemical
properties
were
explored
X-ray
diffraction
(XRD),
attenuated
total
reflection–Fourier
transform
infrared
spectroscopy
(ATR-FTIR),
micro-Raman
spectroscopy,
fluorescent
scanning
electron
microscopy,
wettability
analysis.
For
effects
investigation,
oral
cells
treated
CBN/PVP
examined
MTT
migration
assays,
cell-cycle
ROS
production
analyses.
Gene
expression
determined
qPCR.
To
examine
pro-regenerative
capacity
CBN/PVP,
dental
pulp
stem
cell
cultures
(DPSCs)
subjected
osteo-
chondro-induction.
Results:
Lower
concentrations
(50,
100
μg/mL)
applied
on
exerted
remarkable
cytotoxic
induced
G1
arrest,
reduced
invasion
different
mechanisms,
including
downregulation
PI3K/AKT/mTOR
pathway.
In
contrast,
addition
50
µg/mL
DPSCs
stimulated
their
proliferation.
significantly
enhanced
osteogenic
(p
<
0.05)
chondrogenic
0.01)
induction
DPSCs.
Conclusions:
The
novel
displays
unique
characteristics,
making
it
suitable
therapies
concomitantly.
Oral,
Journal Year:
2025,
Volume and Issue:
5(1), P. 21 - 21
Published: March 20, 2025
Background:
Orthodontics
and
orthognathic
surgery
present
challenges
such
as
extended
treatment
durations,
patient
discomfort,
complications
like
root
resorption.
Recent
advancements
in
tissue
engineering
nanotechnology
offer
promising
solutions
by
improving
bone
regeneration,
periodontal
repair,
biomaterial
integration.
Objectives:
This
review
explores
the
integration
of
scaffold-based
orthodontics,
focusing
on
their
roles
accelerating
reducing
times,
minimizing
adverse
effects
to
enhance
predictability
success
orthodontic
interventions.
Methods:
Relevant
literature
was
selected
from
PubMed,
Scopus,
Web
Science,
studies
related
scaffold
technology,
biomaterials,
orthodontics.
Keywords
included
“tissue
engineering”,
“orthodontics”,
“biomaterials”,
“scaffolds”,
“nanotechnology”,
“bone
regeneration”.
Priority
given
peer-reviewed
original
studies,
systematic
reviews,
meta-analyses
addressing
innovative
approaches
clinical
outcomes.
Results:
Findings
indicate
that
scaffolds
regeneration
while
nanoparticles
improve
drug
delivery
efficiency.
These
contribute
faster,
more
predictable
treatments
with
reduced
complications.
However,
high
costs,
regulatory
hurdles,
need
for
long-term
validation
remain
barriers
widespread
adoption.
Conclusions:
Tissue
minimally
invasive,
biologically
driven
treatment.
While
significant
progress
has
been
made,
further
cost-effective
strategies,
approvals
are
needed
integrate
these
innovations
into
routine
practice.
