Mendelian Randomization Analyses Accounting for Causal Effect of COVID-19 on Brain Imaging-Derived Phenotypes DOI
Jiajie Lu,

Rihong Huang,

Yuecheng Peng

et al.

Journal of Alzheimer s Disease, Journal Year: 2023, Volume and Issue: 96(3), P. 1059 - 1070

Published: Nov. 6, 2023

The coronavirus disease 2019 (COVID-19) has been a major challenge to global health and financial burden. Little is known regarding the possible causal effects of COVID-19 on macro- micro-structures human brain. To determine links between susceptibility, hospitalization, severity brain imaging-derived phenotypes (IDPs). Mendelian randomization (MR) analyses were performed investigate effect three exposures (SARS-CoV-2 infection, hospitalized COVID-19, critical COVID-19) structure employing summary datasets genome-wide association studies. In terms cortical phenotypes, hospitalization due was associated with decrease in surface area (SA) cortex (β= -624.77, 95% CI: -1227.88 -21.66, p = 0.042). At regional level, SARS-CoV-2 infection found have nominally thickness (TH) postcentral region -0.004, -0.007 -0.001, 0.01), as well eight other IDPs. Hospitalized relationship TH 0.01) 6 medial orbitofrontal (β=0.004, 0.001to 0.007, 0.004) 7 IDPs revealed. Our study provides compelling genetic evidence supporting relationships traits This discovery holds promise for enhancing predictions interventions imaging.

Language: Английский

Causal influences of neuropsychiatric disorders on Alzheimer’s disease DOI Creative Commons
Ancha Baranova, Qian Zhao, Hongbao Cao

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 23, 2024

Abstract Previous studies have observed a significant comorbidity between Alzheimer’s disease (AD) and some other neuropsychiatric disorders. However, the mechanistic connections disorders AD are not well understood. We conducted Mendelian randomization analysis to appraise potential influences of 18 neurodegenerative on AD. found that four causally associated with increased risk for AD, including bipolar disorder (BD) (OR: 1.09), migraine schizophrenia 1.05), Parkinson’s (PD) 1.07), while attention-deficit/hyperactivity (ADHD) was decreased 0.80). In case amyotrophic lateral sclerosis 1.04) Tourette’s syndrome there suggestive evidence their causal effects Our study shows genetic components predisposing BD, migraine, schizophrenia, PD may promote development ADHD be reduced The treatments aimed at alleviating diseases earlier onset also influence AD-related cognitive decline, which is typically later in life.

Language: Английский

Citations

16
Exploring the influences of education, intelligence and income on mental disorders DOI Creative Commons
Ancha Baranova, Hongbao Cao, Fuquan Zhang

et al.

General Psychiatry, Journal Year: 2024, Volume and Issue: 37(1), P. e101080 - e101080

Published: Feb. 1, 2024

Background Previous studies have shown that educational attainment (EA), intelligence and income are key factors associated with mental disorders. However, the direct effects of each factor on major disorders unclear. Aims We aimed to evaluate overall independent causal three psychosocial common Methods Using genome-wide association study summary datasets, we performed Mendelian randomisation (MR) multivariable MR (MVMR) analyses assess potential associations between 3 (EA, N=766 345; household income, N=392 422; intelligence, N=146 808) 13 disorders, sample sizes ranging from 9907 807 553. Inverse-variance weighting was employed as main method in analysis. Results Our analysis showed (1) higher EA a protective for eight but contributed anorexia nervosa, obsessive-compulsive disorder (OCD), bipolar (BD) autism spectrum (ASD); (2) five risk OCD ASD; (3) protected against 10 confers nervosa. MVMR attention-deficit/hyperactivity (ADHD) insomnia schizophrenia, BD schizophrenia depressive (MDD) seven including BD, MDD, ASD, post-traumatic stress disorder, ADHD anxiety disorder. Conclusions reveals education, intertwine other. For factor, its present more complex picture than effects.

Language: Английский

Citations

15
Causal Associations between Posttraumatic Stress Disorder and COVID-19 DOI Creative Commons
Ancha Baranova, Li Fu, Yuqing Song

et al.

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(4), P. 68 - 68

Published: April 1, 2024

Objective: We aimed to evaluate bidirectional genetic relationships between posttraumatic stress disorder (PTSD) and COVID-19. Methods: investigated potential causal associations PTSD two COVID-19 conditions (COVID-19 hospitalization SARS-CoV-2 infection) via Mendelian randomization (MR) analyses. Three genome-wide association study (GWAS) summary datasets were used in the study, including (N = 174,659), infection 2,597,856), 2,095,324). performed a literature-based analysis uncover molecular pathways connecting Results: found that exerts effect on (odds ratio (OR): 1.10, 95% confidence interval (CI): 1.00–1.21, p 0.048) hospitalized (OR: 1.34, CI: 1.07–1.67, 0.001). However, both not associated with risk of PTSD. Pathway revealed several immunity-related genes may link Conclusions: Our suggests was increased risks for susceptibility severity. Early diagnosis effective treatment individuals infected coronavirus improve management outcomes

Language: Английский

Citations

5
Exploring the causal effects of depression and antidepressants on COVID-19 DOI Creative Commons
Li Fu, Ancha Baranova, Hongbao Cao

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 359, P. 350 - 355

Published: May 25, 2024

Language: Английский

Citations

4
Causal effects of education, intelligence, and income on COVID-19: evidence from a Mendelian randomization study DOI Creative Commons
Yuqing Song, Ancha Baranova, Hongbao Cao

et al.

Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Feb. 25, 2025

Abstract Background The protective effects of higher educational attainment (EA) and intelligence on COVID-19 outcomes are not yet understood with regard to their dependency income. objective our study was examine the overall as well independent three psychosocial factors susceptibility severity COVID-19. To accomplish this, we utilized genetic correlation, Mendelian randomization (MR), multivariable MR (MVMR) analyses evaluate associations between EA, intelligence, household income, specific outcomes: SARS-CoV-2 infection, hospitalized COVID-19, critical Results correlation analysis revealed that were negatively correlated (r g : -0.19‒-0.36). indicated liability income exerted against infection (OR: 0.86‒0.92), 0.70‒0.80), 0.65‒0.85). MVMR elevated levels EA conferred 0.85), hospitalization due 0.79), 0.63). Furthermore, exhibited a negative association risk 0.91), whereas linked an 1.13). Conclusions Our findings could significantly reduce regardless However, impact or supported by research.

Language: Английский

Citations

0
Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder DOI Creative Commons
Yuqing Song, Yi Zhao, Ancha Baranova

et al.

Psychiatric Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Background Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum (ASD) are two neurodevelopmental disorders that often result in individuals experiencing traumatic events. However, little is known about the connection between ADHD/ASD post-traumatic stress (PTSD). This study aimed to investigate genetic associations these disorders. Methods Genetic correlation analysis was used examine components shared ADHD (38 691 cases 275 986 controls), ASD (18 381 27 969 controls) PTSD (23 212 151 447 controls). Two-sample Mendelian randomization analyses were employed explore bidirectional causal relationships PTSD. Results The results of revealed significant positive correlations with ADHD(r g = 0.70) (r 0.34). Furthermore, liabilities [odds ratio (OR) 1.14; 95% confidence interval (CI), 1.06–1.24; P 7.88 × 10 −4 ] (OR 1.04; CI, 1.01–1.08; 0.014) associated an increased risk developing later life. no evidence supported liability could elevate or ASD. Conclusion findings this may increase PTSD, but not vice versa.

Language: Английский

Citations

3
Causal associations between COVID-19 and childhood mental disorders DOI Creative Commons
Fei Chen, Hongbao Cao, Ancha Baranova

et al.

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 8, 2023

Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can invade both the peripheral and central nervous systems impact function of brain. Therefore, it is necessary to evaluate mutual influences between COVID-19 outcomes childhood mental disorders. Methods We examined genetic correlations potential causalities three disorders phenotypes by genetically proxied analyses. included attention-deficit/hyperactivity disorder (ADHD, N = 292,548), Tourette’s (TS, 14,307), autism spectrum (ASD, 46,350). traits SARS-CoV-2 infection (N 2,597,856), hospitalized 2,095,324), critical 1,086,211). Literature-based analysis was used build gene-based pathways connecting ADHD COVID-19. Results positively correlated with (R g : 0.22 ~ 0.30). Our Mendelian randomization (MR) analyses found that confers a causal effect on (odds ratio (OR): 1.36, 95% confidence interval (CI): 1.10–1.69). TS (OR: 1.14, CI: 1.04–1.25). Genetic liability may not increase risk for Pathway identified several immunity-related genes link COVID-19, including CRP , OXT IL6 PON1 AR TNFSF12 IL10 . Conclusions study suggests augment severity through pathways. However, our results did support role in

Language: Английский

Citations

8
Causal influences of osteoarthritis on COVID-19: a Mendelian randomization study DOI Creative Commons
Li Fu, Ancha Baranova, Hongbao Cao

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 31, 2023

Although observational and genetic studies have indicated a correlation between OA COVID-19, it remains uncertain whether osteoarthritis (OA) contributes to the severity of COVID-19. Here, we aimed investigate potential causal links two.In this study, conducted Mendelian randomization (MR) analysis there is connection COVID-19 outcomes. The utilized publicly available GWAS summary datasets, incorporating data on (N = 455,221), SARS-CoV-2 infection 2,597,856), hospitalized 2,095,324), critical 1,086,211). Additionally, performed literature establish molecular network connecting COVID-19.The MR showed effects (OR: 1.21, 95% CI: 1.02-1.43, p 0.026) 1.35, 1.09-1.68, 0.006) but not as such 1.00, 0.92-1.08, 0.969). Moreover, literature-based pathway uncovered set specific genes, CALCA, ACE, SIRT1, TNF, IL6, CCL2, others, that were found mediate association COVID-19.Our findings indicate elevates risk severe Therefore, larger efforts should be made in prevention patients.

Language: Английский

Citations

5
Causal association of COVID-19 with brain structure changes: Findings from a non-overlapping 2-sample Mendelian randomization study DOI
Pingjian Ding, Rong Xu

Journal of the Neurological Sciences, Journal Year: 2023, Volume and Issue: 454, P. 120864 - 120864

Published: Oct. 31, 2023

Language: Английский

Citations

3
Causal effects of education, intelligence, and income on COVID-19: evidence from a Mendelian randomization study DOI Creative Commons
Yuqing Song, Ancha Baranova, Hongbao Cao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 22, 2024

Abstract Background The protective effects of higher educational attainment (EA) and intelligence on COVID-19 outcomes are not yet understood with regard to their dependency income. objective our study was examine the overall as well independent three psychosocial factors susceptibility severity COVID-19. To accomplish this, we utilized genetic correlation, Mendelian randomization (MR), multivariable MR (MVMR) analyses evaluate associations between EA, intelligence, household income, specific outcomes: SARS-CoV-2 infection, hospitalized COVID-19, critical Results correlation analysis revealed that were negatively correlated (r g : -0.19‒-0.36). indicated liability income exerted infection (OR: 0.86‒0.92), 0.70‒0.80), 0.65‒0.85). MVMR elevated levels EA conferred against 0.85), hospitalization due 0.79), 0.63). Furthermore, exhibited a negative association risk 0.91), whereas linked an 1.13). Conclusions Our findings could significantly reduce regardless However, impact or supported by research.

Language: Английский

Citations

0