Bidirectional associations between mental disorders, antidepressants and cardiovascular disease

BMJ Mental Health, Journal Year: 2024, Volume and Issue: 27(1), P. e300975 - e300975

Published: Jan. 1, 2024

Background Mental disorders have a high comorbidity with cardiovascular disease (CVD), but the causality between them has not been fully appreciated. Objective This study aimed to systematically explore bidirectional two broad categories of diseases. Methods We conducted Mendelian randomisation (MR) and multivariable MR (MVMR) analyses evaluate potential causal links 10 mental disorders, use antidepressants 7 CVDs. Findings discovered that major depressive disorder (MDD), attention-deficit/hyperactivity (ADHD) insomnia exhibit connections elevated risks or more Moreover, is linked heightened each CVD. Each distinct CVD correlated greater probability taking antidepressants. Our MVMR analysis demonstrated elevation respective across all conditions. includes arrhythmias (OR: 1.28), atrial fibrillation 1.44), coronary artery 1.16), hypertension heart failure stroke 1.44) entire group 1.35). However, MDD itself was risk any Conclusions The findings our indicate MDD, ADHD may increase highlight utilisation as an independent factor for CVD, thus explaining influence on through mediating effects Clinical implications When treating patients antidepressants, it necessary take into consideration beneficial detrimental

Language: Английский

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Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 27, 2024

The high comorbidity of major depressive disorder (MDD) with other diseases has been well-documented. However, the pairwise causal connections for MDD comorbid networks are poorly characterized. We performed Phenome-wide Mendelian randomization (MR) analyses to explore bidirectional associations between (N = 807,553) and 877 common from FinnGen datasets 377,277). inverse variance weighting method was primary technique, methods (weighted median MR-Egger) were used sensitivity analyses. Our MR showed that genetic liability is causally associated risks 324 disease phenotypes (average b: 0.339), including 46 psychiatric behavioral disorders 0.618), 18 neurological 0.348), 44 respiratory 0.345), 40 digestive 0.281), circulatory 0.237), 37 genitourinary 0.271), 66 musculoskeletal connective 0.326), 22 endocrine 0.302), others. In a reverse analysis, total 51 components predisposing various risk 0.086), 5 infectious 0.056), 11 0.106), 14 oncological 0.108), 0.114). Bidirectional identified 15 diseases. For most analyses, little evidence heterogeneity pleiotropy detected. findings confirmed extensive significant role predisposition in contributing human phenotypes, which more pronounced than those seen analysis influences on MDD.

Language: Английский

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Gut microbiome and schizophrenia: insights from two-sample Mendelian randomization

Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 2, 2024

Growing evidence suggests a potential link between the gut microbiome and schizophrenia. However, it is unclear whether causally associated with We performed two-sample bidirectional Mendelian randomization to detect causal relationships Summary genome-wide association study (GWAS) datasets of from MiBioGen consortium (n = 18,340) schizophrenia 130,644) were utilized in our study. Then cohort sensitive analyses was followed validate robustness MR results. identified nine taxa that exerted positive effects on (OR: 1.08–1.16) six conferred negative 0.88–0.94). On other hand, reverse analysis showed may increase abundance 1.03–1.08) reduce two 0.94). Our unveiled mutual The findings provide for treatment microbiomes

Language: Английский

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Gut microbiome and major depressive disorder: insights from two-sample Mendelian randomization

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 8, 2024

Abstract Background Existing evidence suggests that alterations in the gut microbiome are closely associated with major depressive disorder (MDD). We aimed to reveal causal relationships between MDD and various microbial taxa gut. Methods used two-sample Mendelian randomization (TSMR) explore bidirectional effects microbiota MDD. The genome-wide association studies summary results of were obtained from two large consortia, MibioGen consortium Dutch Microbiome Project, which we analyzed separately. Results Our TSMR analysis identified 10 bacterial protective against MDD, including phylum Actinobacteria , order Clostridiales family Bifidobacteriaceae (OR: 0.96 ∼ 0.98). Ten an increased risk phyla Firmicutes Proteobacteria class genus Alistipes 1.01 1.09). On other hand, may decrease abundance 12 taxa, families Defluviitaleaceae 0.63 0.88). increase 8 Bacteroidetes genera Parabacteroides Bacteroides 1.12 1.43). Conclusions study supports there mutual certain development suggesting be targeted treatment

Language: Английский

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Evaluating the causal effects of circulating metabolic biomarkers on Alzheimer's disease

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 138, P. 111309 - 111309

Published: March 2, 2025

Language: Английский

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Opposite causal effects of type 2 diabetes and metformin on Alzheimer's disease

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100129 - 100129

Published: March 1, 2025

Type 2 diabetes (T2D) is commonly co-morbid with Alzheimer's disease (AD). However, it remains unclear whether T2D itself or the antidiabetic drug metformin contributes to progression of AD. This study aimed investigate overall and independent effects use on risk Summary genome-wide association datasets were utilized for Mendelian randomization (MR) multivariable MR (MVMR) analyses, including ones (N = 455,017), 456,276), AD 453,733). Additionally, using proportional imbalance method, we analyzed AD-related adverse events in FDA Adverse Event Reporting System (FAERS) database (covering Q1 2004 Q2 2024). Our two-sample analysis indicated that not associated (OR: 1.03, CI: 0.99-1.08, P 0.128). while statistically significant, genetic signature exposure demonstrated a trend toward an increased 1.05, 1.00-1.09, 0.053). Interestingly, MVMR analysis, which evaluates T2D, found robust decrease 0.82, 0.68-0.98, 0.031), was higher 1.26, 1.06-1.50, 9.45E-3). In FAERS database, total 228,283 metformin-related event reports from 67,742 cases found. For as target event, signal reported 29 (ROR: 0.83, 95 % 0.58-1.19, 0.3126). reveals opposite causal These findings highlight importance assessing when prescribing patients T2D.

Language: Английский

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Bidirectional causal associations between plasma metabolites and bipolar disorder

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

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Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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Bidirectional causal effects between bipolar disorder and immune cell traits

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 4, 2024

Language: Английский

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