Bone Regeneration Induced by Patient-Adapted Mg Alloy-Based Scaffolds for Bone Defects: Present and Future Perspectives

Biomimetics, Journal Year: 2023, Volume and Issue: 8(8), P. 618 - 618

Published: Dec. 17, 2023

Treatment of bone defects resulting after tumor surgeries, accidents, or non-unions is an actual problem linked to morbidity and the necessity a second surgery often requires critical healthcare cost. Although surgical technique has changed in modern way, treatment outcome still influenced by patient age, localization defect, associated comorbidities, surgeon approach, systemic disorders. Three-dimensional magnesium-based scaffolds are considered important step because they can have precise defect geometry, high porosity grade, anatomical pore shape, mechanical properties close human bone. In addition, magnesium been proven vitro vivo studies influence regeneration new blood vessel formation positively. this review paper, we describe alloy’s effect on regenerative processes, starting with short description magnesium’s role healing process, host immune response modulation, finishing primary biological mechanism ions angiogenesis osteogenesis presenting detailed analysis based literature review. A strategy that must be followed when patient-adapted scaffold dedicated tissue engineering proposed main fabrication technologies combined, some cases artificial intelligence for Mg alloy scaffolds, presented examples. We emphasized microstructure, properties, corrosion behavior, biocompatibility each study made basis researchers who want start apply potential clinical practice. Challenges, future directions, special applications such as osteosarcoma persistent infection present at end our paper.

Language: Английский

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Surface Analysis of Orthodontic Mini-Implants after Their Clinical Use

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(9), P. 244 - 244

Published: Aug. 24, 2024

Temporary anchorage devices (TADs) are orthodontic mini-implants with remarkable characteristics that, once inserted, present mechanical retention (primary stability) without the process of bone osseointegration. However, interaction biological environment may cause changes in morphology external surface dental TADs. In this study, we used 17 TADs made aluminum-vanadium titanium alloy, produced by two companies, which were analyzed through optical microscopy after being removed from patients during treatment. We evaluated that appeared on TADs' surfaces their use environment, depending morphological area they inserted. our found implant surface, and especially deposits material all study groups. On samples examined clinical use, regardless period corrosion different locations observed. Our obtained results support idea is aggressive for mini-implant structures, always producing to use.

Language: Английский

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Sonodynamic and Enzyme-like Activities of Niobium-based Coatings: Antimicrobial, Cell Proliferation and Cell Differentiation

Journal of Inorganic Materials, Journal Year: 2024, Volume and Issue: 39(10), P. 1125 - 1125

Published: Jan. 1, 2024

Currently, to repair infectious bone defects is still a clinical serious challenge.Here, we prepared heterojunction coating of niobium oxide on pure surface by using microarc oxidation and hydrothermal treatment.We found that the obtained heterogeneous junctions exhibited synchronously enzyme-like ultrasonic dynamic properties triggered ultrasound treatment, especially in acidic microenvironment mimic bacterial infection.Uinder these key conditions, oxidase-like activity was enhanced, generating several reactive oxygen species which can kill bacteria remove their biofilm.Their clearance rates were 91.43% 98.57%, respectively.Under simulated physiological enhanced antioxidant-like enzyme this kind junction, thereby scavenging species, alleviating oxidative stress, promoting proliferation osteo-differentiation rBMSCs.In conclousion, niobium-based coatings with sonodynamic activities has profound potential application prospects repair.

Language: Английский

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Bio-properties of Mg-RE alloys: an applied study on cytotoxicity and genotoxicity

Canadian Metallurgical Quarterly, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Aug. 27, 2024

This study presents a comprehensive review of magnesium alloys with rare elements. It discusses Mg-RE and includes an experimental process. Thus, the data obtained by examining provided better interpretation study. In this study's investigation report, were thoroughly analyzed. part, cytotoxic genotoxic results elements added to Mg-Zn-RE master alloy are discussed. Experiments carried out adding Nd Ce in inverse proportions. data, it was observed that viability rate bacteria increased up 200%. addition, significant obtained, which uncommon literature. As result, new perspective on has been created.

Language: Английский

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Study on degradation tracer and osteogenic ability of CS / NaYF4: Yb3+, Er3+ / AZ31 composites

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 8, 2024

In order to reduce the degradation rate of magnesium alloys and improve their biocompatibility, polymers are often used modify surfaces. However, there is a lack non-invasive means detect polymer coatings, tracking composite important for various applications such as tissue engineering drug delivery. Among imaging tools, upconversion nanoparticles emitting visible light under near-infrared excitation hold promise in post-implantation composites. We therefore report simple synthetic method surface coat AZ31 alloy using chitosan monitor its by release NaYF₄: Yb³⁺, Er³⁺ encapsulated therein cause decrease fluorescence intensity coating. found that addition coating reduced alloy, improved biocompatibility verified osteogenic ability, had linear relationship with time. Thus, this study, prepared AZ31-CN paved way monitoring behavior could be great candidate material bone regeneration.

Language: Английский

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Investment casting of porous Mg-alloy networks biomechanically tuned for bone implant applications

The International Journal of Advanced Manufacturing Technology, Journal Year: 2024, Volume and Issue: 135(7-8), P. 3473 - 3486

Published: Oct. 29, 2024

Abstract Manufacturing technology has been refined and described for the fabrication of honeycomb-based bioresorbable networks temporal bone replacement applications. Two novel techniques, digital light processing investment casting, were utilized to produce customized, shape-optimized cellular constructs with additional orifices promoting tissue ingrowth during osteo-regeneration. For this purpose, a conventional magnesium casting alloy (AZ91) was chosen. Numerical simulations conducted predict compressive behavior proposed biodegradable lightweight scaffolds. Spatial castings adjusted possess mechanical properties comparable ones cortical or trabecular bones. kinds protective coatings (plasma electrolytic oxidation organic based on natural polyphenols from tea extract) deposited characterized. They can be control degradation rate exploitation achieve predictable implant lifespan. The elaborated layers aim mitigate rapid corrosion substrates by prolonging their bioresorption time thus expanding applicability in osseointegration. To evaluate assumption, immersion tests phosphate-buffered saline performed, showing better chemical resistance PEO coating as-cast sample (for both mass gain below 1%), visible increase coated (increase almost 5%). Compressive strength results numerical approach further validated experimental compression tests, that deteriorated 3%, improved it over 9%. Results achieved than expected stiffer sample, slightly lower one bigger pores.

Language: Английский

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Biomechanical analysis of a magnesium plantar plate prototype system for the first tarsometatarsal joint fusion: a cadaveric study

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 28, 2024

Abstract Background Titanium plantar plates have proven successful in the fixation of first tarsometatarsal arthrodesis (TMT). However, a second surgery is typically needed for implant removal, and potential adverse effects, carried by conventional implantations, are not uncommon. The purpose this study was to determine whether novel magnesium-based plate system provides similar fusion stability titanium-based under various loading conditions. Methods Six matched-pair human cadaveric specimens underwent TMT fusions using either magnesium prototype or titanium system. Specimens were cyclically loaded with force ranging from 5 N 50 5,000 cycles, displacement recorded. Axial stiffness (N/mm) calculated load-displacement curves. Each specimen failure at rate mm/min, ultimate load Results No significant difference found vertical between Ti group Mg after 100 cycles (2.4 ± 1.0 mm vs. 1.3 1.4 mm, p = 0.196), 500 (3.3 1.7 0.142), 1,000 (3.7 1.5 1.9 0.128), 2,500 (4.2 2.3 2.2 0.172) (4.5 1.8 3.3 0.125), Additionally, no differences observed initial (53.1 19.2 N/mm 82.2 53.9 N/mm, 0.257), final (90.6 48.9 120.0 48.3 0.319), maximum load-to-failure (259.8 98.2 323.9 134.9 N, 0.369). Conclusions Based on performed biomechanical testing, mechanical equivalent joint fusion.

Language: Английский

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Multiphysics Simulation and Experimental Investigation of HA and Zn-doped HA Coatings on Magnesium Alloys for Resorbable Implant Applications

Materials Today Communications, Journal Year: 2024, Volume and Issue: unknown, P. 111241 - 111241

Published: Dec. 1, 2024

Language: Английский

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A Cross-Linked Coating Loaded with Antimicrobial Peptides for Corrosion Control, Early Antibacterial, and Sequential Osteogenic Promotion on a Magnesium Alloy as Orthopedic Implants

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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