Regulated Magnesium Ion Release From Polydopamine‐Mg Modified Polyetheretherketone Surface for Improved Anti‐Infection and Osseointegration Properties DOI Open Access
Shengdong Liu, Da Li, Tianhua Xiao

et al.

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: 142(10)

Published: Dec. 9, 2024

ABSTRACT Polyetheretherketone (PEEK) emerges as a highly promising biopolymer due to its mechanical properties and elastic modulus akin those of human cortical bone. Despite these advantages, the clinical utilization PEEK is often hindered by limited bioactivity suboptimal capability for bone integration. Herein, we introduce facile expeditious method enhancing osseointegration efficacy substrates depositing polydopamine (PDA) chelated with magnesium ions at varying concentrations (0.02, 0.1, 0.5 M) surface coating (PDA‐Mg). This PDA‐Mg‐modified exhibits distinctive properties, including antibacterial (antibacterial rate 93.267%), improved vascular regeneration, osteogenic promotion (ALP activity increased 239.5%). Moreover, Mg 2+ are released in regulated way, impact concentration on aforementioned has been thoroughly examined. Our study demonstrates that offers prospect applications. Specifically, implants stand out exceptional candidates graft materials, potential significantly improve patient outcomes accelerate recovery processes.

Language: Английский

Bioactive and Protective Calcium Orthophosphate (CaPO4) Deposits on Magnesium and Its Alloys DOI Creative Commons
Sergey V. Dorozhkin

Corrosion and Materials Degradation, Journal Year: 2025, Volume and Issue: 6(1), P. 9 - 9

Published: Feb. 18, 2025

Research on bone regeneration has always been an intense and challenging field of tissue engineering. Biodegradable metals represent a novel class biomaterials combining superior mechanical qualities with capacity to promote growth. Among them, magnesium (Mg) its alloys have proposed as innovative for grafting therapy due their non-toxic nature comparable properties bones. In addition, they are lightweight, biocompatible biodegradable. They offer several advantages over other implant metals, including reduced stress-shielding effects unnecessity second surgery remove them. Unfortunately, clinical application is limited the rapid degradation rates in rather aggressive physiological conditions. Therefore, development Mg-based implants possessing controlled accordance kinetics healing necessary. On hand, protective yet biodegradable surface coatings emerged useful strategy fulfill diverse requirements, effective corrosion resistance. Calcium orthophosphates (abbreviated CaPO4) excellent candidates producing such well tolerated by living organisms. However, high chemical reactivity low melting point, grafts require specific parameters successful CaPO4 deposition. This paper reviews currently available preparation methods deposits Mg alloys, aiming build up comprehensive knowledge framework deposition techniques, processing parameters, performance measures terms resistance, adhesion strength biocompatibility. The literature analysis shows that increase ability magnesium-based metallic withstand improve biocompatibility surfaces all cases.

Language: Английский

Citations

0
Evaluating the Degradation of WE43 for Implant Applications: Optical and Mechanical Insights DOI Creative Commons
Janina Siring,

Anil Cökelek,

Norman MOHNFELD

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(6), P. 3300 - 3300

Published: March 18, 2025

In the context of an ageing society, advancements in medicine and biomedical technology are becoming increasingly important. A major goal is to minimise number surgical operations. Magnesium alloys gaining attention due their degradable properties, good biocompatibility, osteoconductivity. However, for implants made from this material be usable, a precise understanding degradation rate correspondingly adapted design must available. This work focuses on constructing suitable experimental chamber analysis, as well investigating impact sample positioning using two different geometries WE43 alloy potential use osteosynthesis implants. Optical mechanical tests were carried out these geometries. The revealed that affects degradation, with central position yielding most results future applications. addition, demonstrated reduced properties layer. provides initial basis further investigations into implant supports numerical calculation degradation.

Language: Английский

Citations

0
A review on Mg-based metallic glasses for biomedical scaffolds: experimental and computational modeling DOI Open Access
Chijioke Raphael Onyeagba, Tuquabo Tesfamichael

Microstructures, Journal Year: 2025, Volume and Issue: 5(2)

Published: March 24, 2025

Magnesium (Mg)-based metallic glasses have emerged as a promising class of biomaterials for various biomedical applications due to their unique properties, such high strength-to-weight ratio, good biocompatibility and biodegradability. The development Mg-based glass scaffolds is particular interest tissue engineering regenerative medicine applications. However, the rate biodegradability materials not well controlled requires extensive research efficient tissue/bone regeneration. This review provides comprehensive overview recent advancements in tuneable with different compositions thin film coatings. It discusses structural biological mechanical biodegradation behavior, fabrication techniques employed produce bulk scaffolds. Furthermore, explores surface modification permanent implants biodegradable simulate regeneration on implants. Optimization scaffold design increase growth healing by understanding complex interactions between tissues predicting long-term implant behavior using computational models are reviewed. challenges future directions this field also discussed, providing insights into potential applications, including bone engineering, wound healing, cardiovascular

Language: Английский

Citations

0
Osteoimmunomodulation by Bone Implant Materials: Harnessing Physicochemical Properties and Chemical Composition DOI Creative Commons
Mehdi Sanati,

Ines Pieterman,

Natalie Levy

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Optimizing the physicochemical properties of engineered bone implants enhances osseointegration and promotes regeneration by regulating local immune responses.

Language: Английский

Citations

0
Biomimetic multizonal scaffolds for the reconstruction of zonal articular cartilage in chondral and osteochondral defects DOI Creative Commons
Xiaoqi Lin, Ye Zhang, Jiarong Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 43, P. 510 - 549

Published: Oct. 11, 2024

Language: Английский

Citations

2
Influence of Magnesium Degradation on Schwannoma Cell Responses to Nerve Injury Using an In Vitro Injury Model DOI Creative Commons
Krathika Bhat, Lisa Hanke, Heike Helmholz

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(4), P. 88 - 88

Published: March 31, 2024

Nerve guidance conduits for peripheral nerve injuries can be improved using bioactive materials such as magnesium (Mg) and its alloys, which could provide both structural trophic support. Therefore, we investigated whether exposure to Mg Mg-1.6wt%Li thin films (Mg/Mg-1.6Li) would alter acute Schwann cell responses injury. Using the RT4-D6P2T Schwannoma line (SCs), tested extracts from freeze-killed cells (FKC) nerves (FKN) in vitro injury stimulants. Both FKC FKN induced SC release of macrophage chemoattractant protein 1 (MCP-1), a marker repair phenotype after Next, FKC-stimulated exposed Mg/Mg-1.6Li reduced MCP-1 by 30%, suggesting that these have anti-inflammatory effects. Exposing FKC-treated gene expression growth factor (NGF), glial line-derived neurotrophic (GDNF), myelin zero (MPZ), but not p75 neurotrophin receptor. In absence FKC, treatment increased NGF, p75, MPZ, beneficial regeneration. Thus, presence differentially SCs, depending on microenvironment. These results demonstrate applicability this model, has wide-ranging effects phenotype.

Language: Английский

Citations

1
Regulated Magnesium Ion Release From Polydopamine‐Mg Modified Polyetheretherketone Surface for Improved Anti‐Infection and Osseointegration Properties DOI Open Access
Shengdong Liu, Da Li, Tianhua Xiao

et al.

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: 142(10)

Published: Dec. 9, 2024

ABSTRACT Polyetheretherketone (PEEK) emerges as a highly promising biopolymer due to its mechanical properties and elastic modulus akin those of human cortical bone. Despite these advantages, the clinical utilization PEEK is often hindered by limited bioactivity suboptimal capability for bone integration. Herein, we introduce facile expeditious method enhancing osseointegration efficacy substrates depositing polydopamine (PDA) chelated with magnesium ions at varying concentrations (0.02, 0.1, 0.5 M) surface coating (PDA‐Mg). This PDA‐Mg‐modified exhibits distinctive properties, including antibacterial (antibacterial rate 93.267%), improved vascular regeneration, osteogenic promotion (ALP activity increased 239.5%). Moreover, Mg 2+ are released in regulated way, impact concentration on aforementioned has been thoroughly examined. Our study demonstrates that offers prospect applications. Specifically, implants stand out exceptional candidates graft materials, potential significantly improve patient outcomes accelerate recovery processes.

Language: Английский

Citations

0