Nanomaterials Based on Hollow Gold Nanospheres for Cancer Therapy DOI Creative Commons
You Li, Jing Wang, Ying Li

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Gold nanoparticles have recently been exploited as versatile nanocarriers in diagnostic and therapeutic drug delivery for cancer nanomedicine, owing to their biocompatibility, low biotoxicity, surface modifiability plasma optical properties. A variety of gold emerged delivery, mainly including nanorods, nanocages, nanostars, solid nanospheres hollow (HGNs). Among these, HGNs widely studied higher photothermal conversion efficiency, wider spectral absorption range stronger surface-enhanced Raman scattering compared with nanospheres. Therefore, nowadays, researchers prefer use other metal nanocarriers, which can not only play the role controlled-release drugs but also act agents tumor therapy diagnosis, due properties modification. Combined Au-S bond on HGNs, targeted preparation is loaded achieve precise delivery. With assistance characteristics themselves, efficacy enhanced. In addition, vital values field bioimaging, serve imaging scattering-guided preparations assist achieving purpose diagnosis. this review, we summarize synthesis methods recent application HGNs-based nanomaterials diagnosis therapy. issues be addressed were pointed out a bright prospect nanomaterials.

Language: Английский

Near-infrared-driven upconversion nanoparticles with photocatalysts through water-splitting towards cancer treatment DOI
Pranjyan Dash, Pradeep Kumar Panda,

Chaochin Su

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(16), P. 3881 - 3907

Published: Jan. 1, 2024

Water splitting is promising, especially for energy and environmental applications; however, there are limited studies on the link between water cancer treatment. Upconversion nanoparticles (UCNPs) can be used to convert near-infrared (NIR) light ultraviolet (UV) or visible (Vis) have great potential biomedical applications because of their profound penetration ability, theranostic approaches, low self-fluorescence background, reduced damage biological tissue, toxicity. UCNPs with photocatalytic materials enhance activities that generate a shorter wavelength increase tissue depth in microenvironment under NIR irradiation. Moreover, photosensitizer absorb it into UV/vis emit upconverted photons, which excite photoinitiator create H

Language: Английский

Citations

17
Recent progress in functional metal–organic frameworks for bio-medical application DOI Creative Commons

Wenwen Chai,

Xiaochen Chen, Jing Liu

et al.

Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 11

Published: Dec. 23, 2023

Abstract Metal–organic frameworks (MOFs) have a high specific surface area, adjustable pores and can be used to obtain functional porous materials with diverse well-ordered structures through coordination self-assembly, which has intrigued wide interest in broad range of disciplines. In the arena biomedical engineering, functionalized modification MOFs produced drug carriers excellent dispersion functionalities such as target delivery response release, promising applications bio-detection, disease therapy, tissue healing, other areas. This review summarizes present state research on functionalization by physical binding or chemical cross-linking small molecules, polymers, biomacromolecules, hydrogels evaluates role approach boosting reactivity materials. On this basis, application composites engineering fields delivery, repair, treatment, bio-detection imaging is surveyed, development trend prospects an important new class field are anticipated, may provide some inspiration reference for further MOF bio-medical applications.

Language: Английский

Citations

14
Mitochondria-targeting Nanomedicines with Autophagy Inhibitor to Enhance Cancer Photothermal-Chemotherapy DOI Creative Commons
Shuqi Chen, Wenxia Gao,

Shuhua Chang

et al.

Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

In this article, we fabricated nanomedicines with mitochondrial targeting function and autophagy inhibitor for enhancing cancer photothermal-chemotherapy. The nanoparticles were gold (AuNPs) as cores amphiphilic dextran (3-carboxypropyl) triphenyl phosphorus bromide β-cyclodextrin (β-CD) modification (TPP-DCD) shells; the chemotherapeutic doxorubicin (DOX) chloroquine (CQ) encapsulated in nanoparticles. TPP-DCD was synthesized via immobilization of 2-aminoethanethiol modified β-CD triphenylphosphonium on to receive coordination interaction AuNPs mitochondria targeting. size, morphology properties Au@DOX/CQ@TPP-DCD studied. efficiently targeted cellular produce reactive oxygen species photothermal effect under NIR irradiation. released DOX CQ could not only kill tumor cells directly, but also inhibit enhance therapeutic effects. Both vitro vivo anticancer activities investigated detail. imaging demonstrated that exhibited efficient targeting, accumulation retention tumor-bearing mice. apoptosis suppression greatly accelerated addition 808 nm nanomedicine significant synergistic therapy, 75% tumors mice disappeared. nanoparticle is a promising therapy

Language: Английский

Citations

0
Tumor Microenvironment-Responsive Biodegradable Nanomedicine for Self-Enhanced Synergistic Chemo-, Photothermal, and Chemodynamic Therapy DOI
Hanxiao Tang,

Zhi-Hang He,

Chenguang Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

The nanoscale multidrug codelivery system for synergistic therapy is an effective strategy tumor treatment. However, the low drug delivery efficiency and poor therapeutic effects limit its application. Here, based on coordination effect of Artemisinin (Art), quercetin (Qc), Fe

Language: Английский

Citations

3
Inducing Pyroptosis and Cuproptosis Using Copper Carriers for ROS-Augmented Effective Cancer Therapy DOI
Jun Zhong,

Xiao-Chang Lu,

Xiang Zheng

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(9), P. 4282 - 4290

Published: Aug. 20, 2024

Copper overload shows promise as a therapeutic strategy by disrupting copper homeostasis and inducing cell death pathways. However, challenges include the expulsion of excess from cells. This study introduces ZCCP NPs, three-metal MOF nanoparticles that amplify reactive oxygen species (ROS) to enhance cellular uptake reduce efflux. In tumor microenvironment, NPs decompose in response H+ glutathione (GSH), releasing Zn Co ions increase intracellular ROS. Additionally, TMPyP ligand converts Phlorin under near-infrared (NIR) excitation, raising site temperature increasing cancer susceptibility cuproptosis. Elevated ROS activate NLRP3 inflammasome Caspase-1, leading gasdermin D cleavage pyroptosis. Enhanced generation impairs mitochondrial function reduces efflux protein ATP7A expression, promoting combines pyroptosis cuproptosis for effective treatment.

Language: Английский

Citations

2
Nanomaterials Based on Hollow Gold Nanospheres for Cancer Therapy DOI Creative Commons
You Li, Jing Wang, Ying Li

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Gold nanoparticles have recently been exploited as versatile nanocarriers in diagnostic and therapeutic drug delivery for cancer nanomedicine, owing to their biocompatibility, low biotoxicity, surface modifiability plasma optical properties. A variety of gold emerged delivery, mainly including nanorods, nanocages, nanostars, solid nanospheres hollow (HGNs). Among these, HGNs widely studied higher photothermal conversion efficiency, wider spectral absorption range stronger surface-enhanced Raman scattering compared with nanospheres. Therefore, nowadays, researchers prefer use other metal nanocarriers, which can not only play the role controlled-release drugs but also act agents tumor therapy diagnosis, due properties modification. Combined Au-S bond on HGNs, targeted preparation is loaded achieve precise delivery. With assistance characteristics themselves, efficacy enhanced. In addition, vital values field bioimaging, serve imaging scattering-guided preparations assist achieving purpose diagnosis. this review, we summarize synthesis methods recent application HGNs-based nanomaterials diagnosis therapy. issues be addressed were pointed out a bright prospect nanomaterials.

Language: Английский

Citations

0