Nanomaterials Based on Hollow Gold Nanospheres for Cancer Therapy DOI Creative Commons
You Li, Jing Wang, Ying Li

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Gold nanoparticles have recently been exploited as versatile nanocarriers in diagnostic and therapeutic drug delivery for cancer nanomedicine, owing to their biocompatibility, low biotoxicity, surface modifiability plasma optical properties. A variety of gold emerged delivery, mainly including nanorods, nanocages, nanostars, solid nanospheres hollow (HGNs). Among these, HGNs widely studied higher photothermal conversion efficiency, wider spectral absorption range stronger surface-enhanced Raman scattering compared with nanospheres. Therefore, nowadays, researchers prefer use other metal nanocarriers, which can not only play the role controlled-release drugs but also act agents tumor therapy diagnosis, due properties modification. Combined Au-S bond on HGNs, targeted preparation is loaded achieve precise delivery. With assistance characteristics themselves, efficacy enhanced. In addition, vital values field bioimaging, serve imaging scattering-guided preparations assist achieving purpose diagnosis. this review, we summarize synthesis methods recent application HGNs-based nanomaterials diagnosis therapy. issues be addressed were pointed out a bright prospect nanomaterials.

Language: Английский

The micro(nano)plastics perspective: exploring cancer development and therapy DOI Creative Commons
Xiangying Deng,

Yajun Gui,

Lin Zhao

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Language: Английский

Citations

2
Unlocking the Potential of RGD-Conjugated Gold Nanoparticles: A New Frontier in Targeted Cancer Therapy, Imaging, and Metastasis Inhibition DOI
Hossein Javid, Mahsa Akbari Oryani,

Nastaran Rezagholinejad

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10786 - 10817

Published: Jan. 1, 2024

The review highlights the potential of RGD-conjugated AuNPs in cancer diagnosis and treatment, including breast cancer. It emphasizes need for further research to fully realize this technology’s inspire future investigations.

Language: Английский

Citations

5
Near-infrared Photoimmunotherapy: mechanisms, applications, and future perspectives in cancer research DOI Creative Commons
Donald O. Allen,

Madeline JoAnna Szoo,

Tessa D. van Bergen

et al.

Antibody Therapeutics, Journal Year: 2025, Volume and Issue: 8(1), P. 68 - 85

Published: Jan. 1, 2025

Abstract Photoimmunotherapy (PIT) involves the targeted delivery of a photosensitizer through antibody conjugation, which, upon binding to its cellular target and activation by external irradiation, induces localized toxicity. This approach addresses several limitations conventional cancer therapies, such as chemo- radiotherapies, which result in off-target effects that significantly reduce patient quality life. Furthermore, PIT improves on challenges encountered with photodynamic therapy (PDT), nonspecific localization photosensitizer, often results unintended toxicities. Although was first proposed early 1980s, clinical applications have been constrained engineering, conjugation chemistries, optical technologies. However, recent advances antibody–drug conjugate (ADC) research emergence sophisticated laser technologies greatly benefited broader applicability PIT. Notably, near-infrared photoimmunotherapy (NIR-PIT) treatment for head neck has approved Japan is currently phase III trials USA. A significant advantage over traditional ADCs management agnostic nature PDT, making it more adaptable different tumor types. Specifically, can act stem cells displaying resistance aggressive phenotypes—a capability beyond scope alone. review provides an overview mechanism action NIR-PIT, highlighting adaptability application therapeutics, concludes exploring potential advancing treatments.

Language: Английский

Citations

0
Targeting oxygenases could be a viable anti-metastatic approach in cancer therapy DOI
Pengfei Shi, Jie Xu,

Hongjuan Cui

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143375 - 143375

Published: April 1, 2025

Language: Английский

Citations

0
Nanomaterials Based on Hollow Gold Nanospheres for Cancer Therapy DOI Creative Commons
You Li, Jing Wang, Ying Li

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Gold nanoparticles have recently been exploited as versatile nanocarriers in diagnostic and therapeutic drug delivery for cancer nanomedicine, owing to their biocompatibility, low biotoxicity, surface modifiability plasma optical properties. A variety of gold emerged delivery, mainly including nanorods, nanocages, nanostars, solid nanospheres hollow (HGNs). Among these, HGNs widely studied higher photothermal conversion efficiency, wider spectral absorption range stronger surface-enhanced Raman scattering compared with nanospheres. Therefore, nowadays, researchers prefer use other metal nanocarriers, which can not only play the role controlled-release drugs but also act agents tumor therapy diagnosis, due properties modification. Combined Au-S bond on HGNs, targeted preparation is loaded achieve precise delivery. With assistance characteristics themselves, efficacy enhanced. In addition, vital values field bioimaging, serve imaging scattering-guided preparations assist achieving purpose diagnosis. this review, we summarize synthesis methods recent application HGNs-based nanomaterials diagnosis therapy. issues be addressed were pointed out a bright prospect nanomaterials.

Language: Английский

Citations

0