A Microbial Electrochemical Technology to Detect and Degrade Organophosphate Pesticides DOI Creative Commons
Amruta Karbelkar,

Erin. E. Reynolds,

Rachel Ahlmark

et al.

ACS Central Science, Journal Year: 2021, Volume and Issue: 7(10), P. 1718 - 1727

Published: Sept. 21, 2021

Organophosphate (OP) pesticides cause hundreds of illnesses and deaths annually. Unfortunately, exposures are often detected by monitoring degradation products in blood urine, with few effective methods for detection remediation at the point dispersal. We have developed an innovative strategy to remediate these compounds: engineered microbial technology targeted destruction OP pesticides. This system is based upon electrochemistry using two strains. The strains combined such that first microbe (E. coli) degrades pesticide, while second (S. oneidensis) generates current response product without requiring external electrochemical stimulus or labels. cellular unique E. coli serves only as inert scaffold enzymes degrade OPs, circumventing a fundamental requirement coculture design: maintaining viability simultaneously. With this platform, we can detect submicromolar levels, outperforming reported colorimetric fluorescence sensors. Importantly, approach affords modular, adaptable be expanded additional environmental contaminants.

Language: Английский

Global trends in pesticides: A looming threat and viable alternatives DOI
Akanksha Sharma, Ananya Shukla,

Kriti Attri

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 201, P. 110812 - 110812

Published: June 5, 2020

Language: Английский

Citations

432
Neurotoxicity in acute and repeated organophosphate exposure DOI Creative Commons
Sean X. Naughton, Alvin V. Terry

Toxicology, Journal Year: 2018, Volume and Issue: 408, P. 101 - 112

Published: Aug. 23, 2018

Language: Английский

Citations

267
A treatise on Organophosphate pesticide pollution: Current strategies and advancements in their environmental degradation and elimination DOI Creative Commons
Jyoti Kaushal, Madhu Khatri, Shailendra Kumar Arya

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 207, P. 111483 - 111483

Published: Oct. 22, 2020

Pesticides have been used in the field of agriculture ever since their role protection crops from pests which include four different categories namely insects, mites, rodents and animals has identified. Organophosphate pesticides are one most extensively applied insecticides such that around 40% all produced commercially belong to this category. The main toxicological effect these when exposed a living being encompasses irremediable inhibition acetylcholinesterase (AChE) enzyme is involved neurotransmission signals hence its causes impairment respiratory tract neuromuscular transmission. Apart as pesticide, organophosphates also herbicides some extent. residues highly toxic chemicals found route into underground water system by seeping ground, rivers where agricultural run off disposed, air sprayed on posing threat strata various ways discussed further. Many significant studies carried out order evaluate health risks associated with commonly acute neurological disorders. This review emphasizes effects organophosphate recent methods detection identify trace amounts along strategies for degradation.

Language: Английский

Citations

246
Organophosphate exposures during pregnancy and child neurodevelopment: Recommendations for essential policy reforms DOI Creative Commons
Irva Hertz‐Picciotto, Jennifer Sass, Stephanie M. Engel

et al.

PLoS Medicine, Journal Year: 2018, Volume and Issue: 15(10), P. e1002671 - e1002671

Published: Oct. 24, 2018

In a Policy Forum, Irva Hertz-Picciotto and colleagues review the scientific evidence linking organophosphate pesticides to cognitive, behavioral, neurological deficits in children recommend actions reduce exposures.

Language: Английский

Citations

207
Essential oils as active ingredients of botanical insecticides against aphids DOI
Ikbal Chaieb, Roman Pavela

Journal of Pest Science, Journal Year: 2019, Volume and Issue: 92(3), P. 971 - 986

Published: Feb. 5, 2019

Language: Английский

Citations

147
The growing concern of chlorpyrifos exposures on human and environmental health DOI

Nilay Kumar Nandi,

Akshun Vyas,

Md Jawaid Akhtar

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2022, Volume and Issue: 185, P. 105138 - 105138

Published: June 10, 2022

Language: Английский

Citations

91
Phosphine Oxides from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery DOI

Peter Finkbeiner,

Jörg P. Hehn,

Christian Gnamm

et al.

Journal of Medicinal Chemistry, Journal Year: 2020, Volume and Issue: 63(13), P. 7081 - 7107

Published: June 1, 2020

Phosphine oxides and related phosphorus-containing functional groups such as phosphonates phosphinates are established structural motifs that still underrepresented in today's drug discovery projects, only few examples can be found among approved drugs. In this account, the physicochemical vitro properties of phosphine reported compared to more commonly used discovery. Furthermore, impact on a real scaffold is exemplified by series analogs imatinib. We demonstrate highly polar leading high solubility metabolic stability but occasionally at cost reduced permeability. conclude valuable elements they deserve considered routine part every medicinal chemist's toolbox.

Language: Английский

Citations

132
Enzymatic Bioremediation of Organophosphate Compounds—Progress and Remaining Challenges DOI Creative Commons
Meghna Thakur, Igor L. Medintz, Scott A. Walper

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2019, Volume and Issue: 7

Published: Nov. 8, 2019

Organophosphate compounds are ubiquitously employed as agricultural pesticides and maintained chemical warfare agents by several nations. These highly toxic, show environmental persistence accumulation, contribute to numerous cases of poisoning death each year. While their use weapons mass destruction is rare, these never fully disappear into obscurity they continue be tools fear control governments terrorist organizations. Beyond weaponization, wide-scale dissemination products has led accumulation intoxication soil water across the globe. Therefore, there a dire need for rapid safe bioremediation, personal decontamination, therapeutic detoxicants. hydrolyzing enzymes emerging appealing targets satisfy decontamination needs owing ability hydrolyze both nerve using biologically-derived materials environment individual. As release genetically modified organisms not widely accepted practice, researchers exploring alternative strategies organophosphate bioremediation that focus on cell-free enzyme systems. In this review, we first discuss more prevalent organophosphorus along with research engineering efforts have an enhancement in activity, substrate tolerance, stability. later half advances achieved through focusing enhancing catalytic activity stability phosphotriesterase, model hydrolase, various approaches such nanoparticle display, DNA scaffolding, outer membrane vesicle encapsulation.

Language: Английский

Citations

127
Endocrine disrupting chemicals: Impacts on human fertility and fecundity during the peri-conception period DOI
Mark P. Green, Alexandra J. Harvey,

Bethany J. Finger

et al.

Environmental Research, Journal Year: 2020, Volume and Issue: 194, P. 110694 - 110694

Published: Dec. 30, 2020

Language: Английский

Citations

123
Proton-Coupled Electron Transfer Enables Tandem Radical Relay for Asymmetric Copper-Catalyzed Phosphinoylcyanation of Styrenes DOI

Guoyu Zhang,

Liang Fu, Pinhong Chen

et al.

Organic Letters, Journal Year: 2019, Volume and Issue: 21(13), P. 5015 - 5020

Published: June 17, 2019

A tandem radical relay strategy was realized for the first Cu(I)-catalyzed enantioselective phosphinocyanation of styrenes. In this reaction, tBuOOSiMe3 generated in situ from tBuOOH serves as a initiator to trigger t-butoxy production upon oxidization L*Cu(I) species via proton-coupled-electron transfer (PCET) pathway, which leads sequential phosphinoyl and benzyl formations. The resultant β-cyanodiarylphosphine oxides could be easily converted series chiral γ-amino phosphine ligands.

Language: Английский

Citations

79