A treatise on Organophosphate pesticide pollution: Current strategies and advancements in their environmental degradation and elimination

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 207, P. 111483 - 111483

Published: Oct. 22, 2020

Pesticides have been used in the field of agriculture ever since their role protection crops from pests which include four different categories namely insects, mites, rodents and animals has identified. Organophosphate pesticides are one most extensively applied insecticides such that around 40% all produced commercially belong to this category. The main toxicological effect these when exposed a living being encompasses irremediable inhibition acetylcholinesterase (AChE) enzyme is involved neurotransmission signals hence its causes impairment respiratory tract neuromuscular transmission. Apart as pesticide, organophosphates also herbicides some extent. residues highly toxic chemicals found route into underground water system by seeping ground, rivers where agricultural run off disposed, air sprayed on posing threat strata various ways discussed further. Many significant studies carried out order evaluate health risks associated with commonly acute neurological disorders. This review emphasizes effects organophosphate recent methods detection identify trace amounts along strategies for degradation.

Language: Английский

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Organophosphate pesticides an emerging environmental contaminant: Pollution, toxicity, bioremediation progress, and remaining challenges

Journal of Environmental Sciences, Journal Year: 2022, Volume and Issue: 127, P. 234 - 250

Published: April 30, 2022

Language: Английский

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Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 15, 2024

An interdisciplinary fetal-neonatal neurology (FNN) program over the first 1,000 days teaches perspectives of neural exposome that are applicable across life span. This curriculum strengthens neonatal neurocritical care, pediatric, and adult training objectives. Teaching at maternal-pediatric hospital centers optimally merges reproductive, pregnancy, pediatric approaches to healthcare. Phenotype–genotype expressions health or disease pathways represent a dynamic developmental time. The science uncertainty applied FNN re-enforces importance shared clinical decisions minimize bias reduce cognitive errors. Trainees select mentoring committee participants will maximize their learning experiences. Standardized questions oral presentations monitor educational progress. Master doctoral defense preparation competitive research funding can be goals for specific individuals. principles practice offer an understanding gene–environment interactions recognizes effects reproductive on maternal-placental-fetal triad, neonate, child, adult. Pre-conception prenatal adversities potentially diminish life-course brain health. Endogenous exogenous toxic stressor interplay (TSI) alters through maladaptive neuroplasticity. Developmental disorders epilepsy primarily expressed during days. Communicable noncommunicable illnesses continue interact with express diverse neurologic lifespan, particularly critical/sensitive time periods adolescence senescence. Anomalous destructive fetal neuropathologic lesions change this developmental-aging continuum. integrated placental, neonatal, childhood, offers perspective exposome. Exosome promises improved monitoring drug delivery starting pregnancy. origins anticipate diagnoses interventions benefit successive generations. Addressing care disparities in Global South high-income country medical deserts require constructive dialogue among stakeholders achieve equity. Population policies capital strategy reduces global burden diseases by applying practice. integrative approach prolong survival quality persons lifespan confronted neurological disorders.

Language: Английский

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Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Environmental Science and Pollution Research, Journal Year: 2020, Volume and Issue: 27(21), P. 26036 - 26057

Published: May 12, 2020

Language: Английский

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Enzymatic Bioremediation of Organophosphate Compounds—Progress and Remaining Challenges

Frontiers in Bioengineering and Biotechnology, Journal Year: 2019, Volume and Issue: 7

Published: Nov. 8, 2019

Organophosphate compounds are ubiquitously employed as agricultural pesticides and maintained chemical warfare agents by several nations. These highly toxic, show environmental persistence accumulation, contribute to numerous cases of poisoning death each year. While their use weapons mass destruction is rare, these never fully disappear into obscurity they continue be tools fear control governments terrorist organizations. Beyond weaponization, wide-scale dissemination products has led accumulation intoxication soil water across the globe. Therefore, there a dire need for rapid safe bioremediation, personal decontamination, therapeutic detoxicants. hydrolyzing enzymes emerging appealing targets satisfy decontamination needs owing ability hydrolyze both nerve using biologically-derived materials environment individual. As release genetically modified organisms not widely accepted practice, researchers exploring alternative strategies organophosphate bioremediation that focus on cell-free enzyme systems. In this review, we first discuss more prevalent organophosphorus along with research engineering efforts have an enhancement in activity, substrate tolerance, stability. later half advances achieved through focusing enhancing catalytic activity stability phosphotriesterase, model hydrolase, various approaches such nanoparticle display, DNA scaffolding, outer membrane vesicle encapsulation.

Language: Английский

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Acetylcholinesterase inhibitors (nerve agents) as weapons of mass destruction: History, mechanisms of action, and medical countermeasures

Neuropharmacology, Journal Year: 2020, Volume and Issue: 181, P. 108298 - 108298

Published: Sept. 6, 2020

Language: Английский

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A review of health effects associated with exposure to jet engine emissions in and around airports

Environmental Health, Journal Year: 2021, Volume and Issue: 20(1)

Published: Feb. 6, 2021

Abstract Background Airport personnel are at risk of occupational exposure to jet engine emissions, which similarly diesel exhaust emissions include volatile organic compounds and particulate matter consisting an inorganic carbon core with associated polycyclic aromatic hydrocarbons, metals. Diesel is classified as carcinogenic the fraction has in itself been linked several adverse health effects including cancer. Method In this review, we summarize available scientific literature covering human airport both settings for residents living close airports. We also report findings from limited mechanistic studies animal cell models. Results Jet contain large amounts nano-sized particles, particularly prone reach lower airways upon inhalation. Size particles emission levels depend on type aircraft, conditions, fuel type, well operation modes. Exposure reported be biomarkers effect among personnel, especially ground-support functions. Proximity running engines or such residential areas increased disease, hospital admissions self-reported lung symptoms. Conclusion conclude that though scarce low consistency methods measured biomarkers, there evidence have physicochemical properties similar other traffic emissions.

Language: Английский

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Mechanisms of organophosphate neurotoxicity

Current Opinion in Toxicology, Journal Year: 2021, Volume and Issue: 26, P. 49 - 60

Published: April 30, 2021

Language: Английский

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Surface imprinted CoZn-bimetalic MOFs as selective colorimetric probe: Application for detection of dimethoate

Sensors and Actuators B Chemical, Journal Year: 2020, Volume and Issue: 325, P. 128768 - 128768

Published: Sept. 2, 2020

Language: Английский

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Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4523 - 4523

Published: April 20, 2022

Organophosphorus pesticides (OPs) are widespread insecticides used for pest control in agricultural activities and the of vectors human animal diseases. However, OPs’ neurotoxic mechanism involves cholinergic components, which, beyond being involved transmission neuronal signals, also influence activity cytokines other pro-inflammatory molecules; thus, acute chronic exposure to OPs may be related development degenerative pathologies inflammatory The present article reviews discusses experimental evidence linking process with OP-induced dysregulation, emphasizing molecular mechanisms role cellular alterations humans models, possible therapeutic targets inhibit inflammation.

Language: Английский

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