Neuron-derived Extracellular Vesicles in Blood Reveal Effects of Exercise in Alzheimer’s Disease DOI Creative Commons
Francheska Delgado‐Peraza, Carlos Nogueras‐Ortiz, Anja Hviid Simonsen

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: April 5, 2023

Abstract Background Neuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for effects of exercise Alzheimer’s disease (AD). For this purpose, we studied changes neuroprotective proteins proBDNF, BDNF and humanin plasma NDEVs from patients with mild moderate AD participating the randomized controlled trial (RCT) ADEX. Methods were quantified immunocaptured 95 ADEX participants, into control groups, collected at baseline 16-weeks. Exploratorily, also NDEV levels putative exerkines known respond peripheral tissues. Results increased group, especially APOE ε4 carriers, but remained unchanged group. Inter-correlations between observed maintained after exercise. unchanged. Conclusions Findings suggest that cognitive benefits could mediated by upregulation factors NDEVs. Additionally, our results indicate subjects carrying are more responsive physical activity. Unchanged activity imply engages different pathways neurons Future studies should aim expand upon duration, intensity, type early additional neurodegenerative disorders. Trial registration: The Effect Physical Exercise Alzheimer Patients (ADEX) was registered as ClinicalTrials.gov Identifier: NCT01681602 first submitted on April 30, 2012 met QC criteria September 5, 2012.

Language: Английский

An NIMH Workshop on Non-Affective Psychosis in Midlife and Beyond: Research Agenda on Phenomenology, Clinical Trajectories, Underlying Mechanisms, and Intervention Targets DOI Creative Commons
Ellen Lee, David H. Adamowicz, Sophia Frangou

et al.

American Journal of Geriatric Psychiatry, Journal Year: 2023, Volume and Issue: 31(5), P. 353 - 365

Published: Feb. 1, 2023

Language: Английский

Citations

2
Research progress in role of exosomes exosomes in mental disorders. DOI
Jialing Wu,

Shansi Li,

Yi Zhang

et al.

PubMed, Journal Year: 2023, Volume and Issue: 48(5), P. 771 - 781

Published: May 28, 2023

Exosomes are a class of extracellular vesicles with structure lipid bilayer-membrane. In the central nervous system (CNS), exosomes can be secreted from both neurons and glial cells. released into matrix freely cross blood-brain barrier function as crucial carriers cellular communication substance exchange in CNS. play key role pathological process mental disorders such schizophrenia, depression, bipolar disorder, they have potential to used targeted carrier antipsychotic medications. likely become new tool future aid early prevention, accurate diagnosis, effective treatment for people disorders.

Language: Английский

Citations

1
Neuroprotective effects of annexin A1 tripeptide in rats with sepsis‐associated encephalopathy DOI

Qiao Cui,

Nannan Qin,

Yonghan Zhang

et al.

Biotechnology and Applied Biochemistry, Journal Year: 2024, Volume and Issue: 71(4), P. 701 - 711

Published: Feb. 26, 2024

Abstract Sepsis‐associated encephalopathy (SAE) is characterized by high incidence and mortality rates, with limited treatment options available. The underlying mechanisms pathogenesis of SAE remain unclear. Annexin A1 (ANXA1), a membrane‐associated protein, involved in various vivo pathophysiological processes. This study aimed to explore the neuroprotective effects novel bioactive ANXA1 tripeptide (ANXA1sp) SAE. Forty Sprague–Dawley rats were randomly divided into four groups ( n = 10 each): control, (intraperitoneal injection lipopolysaccharide), vehicle (SAE + normal saline), ANXA1sp ANXA1sp) groups. Changes serum inflammatory factors (interleukin‐6 [IL‐6], tumor necrosis factor‐α [TNF‐α]), hippocampal reactive oxygen species (ROS), mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) levels measured. Morris water maze Y tests used assess learning memory capabilities rats. Further, changes peroxisome proliferator–activated receptor‐gamma (PPAR‐γ) apoptosis‐related protein expression detected using western blot. IL‐6, TNF‐α, ROS significantly increased group compared control group. Intraperitoneal administration led significant decrease p < 0.05). Compared group, exhibited reduced escape latency on day 5, increase number platform crossings percent spontaneous alternation, higher MMP ATP Meanwhile, level PPAR‐γ was that other expressions proteins (nuclear factor‐kappa B [NF‐κB], Bax, Caspase‐3) increased, noticeable Bcl‐2 expression, noted Moreover, NF‐κB, Caspase‐3 decreased markedly can effectively reverse cognitive impairment effect may be attributed activation pathway, resulting neuroinflammatory response inhibition apoptosis.

Language: Английский

Citations

0
Psychotic Disorders and exosomes: An overview of current evidence and future directions DOI Creative Commons
Charles Desmeules, Olivier Corbeil, Maxime Huot‐Lavoie

et al.

Psychiatry Research, Journal Year: 2024, Volume and Issue: 339, P. 116066 - 116066

Published: July 6, 2024

Language: Английский

Citations

0
Identification of Schizophrenia Susceptibility Loci in the Urban Taiwanese Population DOI Creative Commons
Chih-Chung Huang,

Yiguang Wang,

Chun-Lun Hsu

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(8), P. 1271 - 1271

Published: Aug. 6, 2024

: Genomic studies have identified several SNP loci associated with schizophrenia in East Asian populations. Environmental factors, particularly urbanization, play a significant role development. This study aimed to identify susceptibility and characterize their biological functions molecular pathways Taiwanese urban Han individuals.

Language: Английский

Citations

0
Neuron-derived Extracellular Vesicles in Blood Reveal Effects of Exercise in Alzheimer’s Disease DOI Creative Commons
Francheska Delgado‐Peraza, Carlos Nogueras‐Ortiz, Anja Hviid Simonsen

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: April 5, 2023

Abstract Background Neuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for effects of exercise Alzheimer’s disease (AD). For this purpose, we studied changes neuroprotective proteins proBDNF, BDNF and humanin plasma NDEVs from patients with mild moderate AD participating the randomized controlled trial (RCT) ADEX. Methods were quantified immunocaptured 95 ADEX participants, into control groups, collected at baseline 16-weeks. Exploratorily, also NDEV levels putative exerkines known respond peripheral tissues. Results increased group, especially APOE ε4 carriers, but remained unchanged group. Inter-correlations between observed maintained after exercise. unchanged. Conclusions Findings suggest that cognitive benefits could mediated by upregulation factors NDEVs. Additionally, our results indicate subjects carrying are more responsive physical activity. Unchanged activity imply engages different pathways neurons Future studies should aim expand upon duration, intensity, type early additional neurodegenerative disorders. Trial registration: The Effect Physical Exercise Alzheimer Patients (ADEX) was registered as ClinicalTrials.gov Identifier: NCT01681602 first submitted on April 30, 2012 met QC criteria September 5, 2012.

Language: Английский

Citations

0