Published: Jan. 1, 2024
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Language: Английский
JOGN Nursing, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
2
The FASEB Journal, Journal Year: 2023, Volume and Issue: 37(9)
Published: Aug. 29, 2023
Endometriosis is a common estrogen-dependent disorder wherein uterine lining tissue (endometrium) found mainly in the pelvis where it causes inflammation, chronic pelvic pain, pain with intercourse and menses, infertility. Recent evidence also supports systemic inflammatory component that underlies associated co-morbidities, e.g., migraines cardiovascular autoimmune diseases. Genetics environment contribute significantly to disease risk, explosion of omics technologies, underlying mechanisms symptoms are increasingly being elucidated, although novel effective therapeutics for infertility have lagged behind these advances. Moreover, there stark disparities diagnosis, access care, treatment among persons color transgender/nonbinary identity, socioeconomically disadvantaged populations, adolescents, disturbing low awareness health care providers, policymakers, lay public about endometriosis, which, if left undiagnosed under-treated can lead significant fibrosis, infertility, depression, markedly diminished quality life. This review summarizes endometriosis epidemiology, compelling its pathogenesis, pathophysiology age precision medicine, recent biomarker discovery, therapeutic approaches, issues around reproductive justice marginalized populations this spanning past 100 years. As we enter next revolution biomedical research, rich molecular clinical datasets, single-cell omics, population-level data, well positioned benefit from data-driven research leveraging computational artificial intelligence approaches integrating data predicting response medical surgical therapies, prognosis recurrence.
Language: Английский
Citations
32
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Dec. 4, 2023
Endometriosis is an incurable, under-diagnosed, systemic inflammatory disease affecting millions world-wide. Common symptoms include life-impacting pain, gastrointestinal/urinary symptoms, excessive fatigue, and infertility. Global public health policies are urgently needed to promote awareness, implement multidisciplinary care, fund research for aetiology, biomarker discovery, effective therapies associated with endometriosis.
Language: Английский
Citations
23
Radiology, Journal Year: 2024, Volume and Issue: 312(3)
Published: Sept. 1, 2024
Endometriosis is a common condition impacting approximately 190 million individuals and up to 50% of women with infertility globally. The disease characterized by endometrial-like tissue located outside the uterine corpus, which causes cyclical hemorrhage, inflammation, fibrosis. Based on clinical suspicion or findings at routine transvaginal pelvic US other prior imaging, dedicated imaging for endometriosis may be warranted MRI advanced US. Deep (DE) in pelvis includes evaluation stromal fibrotic components architectural distortion resulting from fibrosis tethering. It requiring compartment-based, pattern-recognition approach. has benefit global assessment effective assessing features malignancy evaluating extrapelvic locations. Transvaginal advantage dynamic maneuvers assess adhesions achieve higher spatial resolution depth bowel wall invasion. T1-weighted increases specificity diagnosis identifying hemorrhagic components, but presence T1 signal hyperintensity not essential diagnosing DE. broad spectrum; understanding mild through manifestations, including evaluation, within scope breadth radiologists' interpretation.
Language: Английский
Citations
10
Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 266, P. 155813 - 155813
Published: Jan. 9, 2025
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7068 - 7068
Published: June 27, 2024
Endometriosis is a chronic inflammatory disorder characterized by the abnormal growth of endometrial-like tissue outside uterine cavity, affecting 10-15% women reproductive age. Pain most common symptom. Treatment options include surgery, which has limited effectiveness and high recurrence rates, pharmacotherapy. Hormonal therapies, commonly used for symptom management, can have side effects contraceptive outcomes, contributing to infertility associated with endometriosis, pain lesions often reappearing after treatment cessation. Among its etiological factors, immunological dysregulation plays significant role, representing an interesting target developing new therapeutic strategies. This review critically analyzes recent studies provide updated synthesis ongoing research into potential pharmacotherapies focusing on lesion progression, relief, improving quality life. Immunotherapy, natural anti-inflammatory antioxidant compounds drug repurposing show promise in addressing limitations current treatments targeting potentially offering non-invasive solutions managing endometriosis. Promising results been obtained from vitro animal model studies, but clinical trials are still limited. More effort needed translate these findings practice effectively reduce disease alleviate symptoms preserve capacity, patients' overall wellbeing.
Language: Английский
Citations
6
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 4, 2024
Endometriosis is a prevalent gynecological disorder characterized by the ectopic growth of endometrial-like tissue outside uterus. This condition poses significant challenges due to its chronic nature, debilitating symptoms such as pelvic pain and infertility, substantial impact on quality life. Central pathogenesis endometriosis are inflammatory mechanisms that perpetuate proliferation, adhesion formation, immune dysregulation within cavity. Inflammation plays pivotal role in development progression endometriosis, influencing severity complications associated with disease. Dysregulated responses contribute persistence endometrial implants, exacerbating other experienced affected individuals. Moreover, milieu created endometriotic lesions disrupts normal ovarian function, impairs follicular development, compromises reproductive outcomes, thereby posing fertility. review comprehensively explores underlying their implications for Synthesizing current research clinical insights elucidates intricate interplay between inflammation, disease progression, health outcomes. Understanding these complex interactions essential developing targeted diagnostic strategies optimizing therapeutic approaches tailored alleviate improve fertility outcomes individuals endometriosis. Ultimately, this aims enhance understanding pathophysiology, inform practice, stimulate further advance personalized care management challenging condition.
Language: Английский
Citations
6
npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)
Published: Feb. 6, 2025
Endometriosis is an enigmatic disease whose diagnosis and management are being transformed through innovative surgical, molecular, computational technologies. Integrating single-cell other omic data with clinical surgical metadata can identify multiple subtypes translation to novel diagnostics therapeutics. Herein, we present real-world perspectives on endometriosis the importance of multidisciplinary collaboration in informing epidemiologic, cell-specific contexts.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 17, 2025
Human longevity is a sex-biased process in which sex chromosomes and sex-specific immunity may play crucial role the health lifespan disparities between men women. Generally, women have higher life expectancy than men, exhibiting lower infection rates for broad range of pathogens, results prevalence female centenarians compared to males. Investigation immunological changes that occur during healthy aging, while taking into account differences sexes, can significantly enhance our understanding mechanisms underlie longevity. In this review, we aim summarize current knowledge on sexual dimorphism human immune system gut microbiome with particular focus centenarians, based exclusively data.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2458 - 2458
Published: March 10, 2025
Endometriosis is a complex gynecological disorder characterized by endometrial-like tissue growing outside the uterus, leading to chronic pain, infertility, and reduced quality of life. Its pathophysiology involves genetic, epigenetic, immune, molecular factors. Theories such as retrograde menstruation, coelomic metaplasia, stem cell involvement explain lesion formation. Endometrial mesenchymal cells (eMSCs) epithelial progenitors (eEPs) contribute establishment adhering peritoneal surfaces, proliferating, differentiating into ectopic tissue. Aberrant adhesion molecules, inflammatory cytokines, pathways like PI3K/Akt Wnt/β-catenin drive proliferation, angiogenesis, resistance apoptosis. Elevated estrogen levels progesterone further promote growth immune evasion. Immune dysfunction, including altered macrophage activity natural killer (NK) function, contributes inflammation persistence. Pain linked prostaglandin E2 (PGE2) nerve infiltration, emphasizing need for targeted pain management. Current therapies, GnRH agonists, suppress ovarian hormone production but face limitations in long-term efficacy side effects. Integrating insights clinical practice may advance diagnostics treatment, with emerging approaches focusing on pathways, modulation, hormonal regulation more effective, personalized therapies. Future research should unravel mechanisms driving endometriosis improve patient outcomes.
Language: Английский
Citations
0