Decoding immune tolerance in infertility: Exploring immune pathways and non-coding RNAs as pioneering biomarkers and therapeutic targets

Human Immunology, Journal Year: 2025, Volume and Issue: 86(3), P. 111264 - 111264

Published: Feb. 20, 2025

Language: Английский

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Endometriosis and Infertility: Gynecological Examination Practical Guide

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1904 - 1904

Published: March 12, 2025

Endometriosis, a prevalent gynecological condition affecting 10–15% of reproductive-age women, involves the growth endometrial-like tissue outside uterine cavity. This chronic inflammatory disease can significantly impact fertility by disrupting ovulation, tubal transport, and implantation. Clinical manifestations vary widely, ranging from asymptomatic cases to severe pelvic pain, dysmenorrhea, dyspareunia. Accurate diagnosis remains challenging, often requiring combination patient history, clinical examination, imaging studies. paper will discuss approach endometriosis during first-line appointment, focusing on including detailed assessment menstrual, pelvic, bowel symptoms, examination; thorough abdominal palpation, speculum bimanual evaluation (particularly role ultrasound in identifying characterizing endometriotic lesions, use #ENZIAN classification for deep infiltrating impact); discussion Endometriosis Fertility Index (EFI) as tool assessing potential. comprehensive aims guide clinicians managing effectively, improving outcomes optimizing management strategies. Methods: A literature search suitable articles published January 1974 2024 English language was performed using PubMed. Results: is associated with infertility rates 20% 68%, mechanisms adhesions, inflammation, immune dysregulation. The revised American Society Reproductive Medicine (rASRM) were identified essential tools staging disease. Transvaginal (TVS) demonstrated high diagnostic accuracy endometriosis, sensitivity up 96% specificity 99%. EFI emerged valuable predictor natural conception post-surgery. Additionally, review underscores frequent co-occurrence adenomyosis women which may further compromise fertility. Despite advancements techniques systems, variability symptom presentation progression continues challenge early effective management. Conclusions: reproductive age infertility. describes physical imaging, particularly ultrasound, lesions. adoption standardized systems such enhances prognosis, allowing tailored treatment improvements non-invasive methods, challenges persist correlating severity extent, necessitating continued research into biomarkers novel techniques. coexistence complicates outcomes, underscoring need Further needed enhance detection strategies optimize preservation affected women.

Language: Английский

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Exploring the link between serum uric acid and endometriosis: a cross-sectional analysis utilizing NHANES data from 1999-2006

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Background Substantial impacts on the female reproductive system have been definitively linked to heightened levels of serum uric acid. However, evidence directly linking increased acid endometriosis in women remains sparse, and precise characteristics this influence are still not fully understood. Objective To explore exact relationship between endometriosis. Study design Referencing data accumulated from National Health Nutrition Examination Survey (NHANES), study covers period 1999 2006, conducted an analysis 5,162 participants aged 20 54 years (representing a sample size approximately 66,927,890 women). The adopted cross-sectional methodology delve into tie prevalence Utilizing rigorous methodologies, including weighted multivariable logistic regression models, subgroup analyses, statistical methodologies for smooth curve fitting. Results A positive association was found continuous risk (OR = 1.25, 95% CI [1.09, 1.44], P 0.003). At same time, highest quartile had 133% higher compared with lowest (OR=2.33,95%CI [1.28, 4.23], P=0.009). fitting also linear correlation There no heterogeneity analysis. Conclusion indicates strong link appearance women. Specifically, elevated face likelihood developing

Language: Английский

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Fibrinogen Structural Changes and Their Potential Role in Endometriosis-Related Thrombosis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1456 - 1456

Published: Nov. 27, 2024

Endometriosis (EM), a chronic inflammatory condition predominantly affecting women of reproductive age, has been linked to an elevated risk thrombosis, though its underlying molecular mechanisms remain incompletely understood. In this case-control study, involving 71 EM patients and matched controls, we explored the structural functional changes in fibrinogen their potential role thrombosis. Key oxidative stress markers, such as reactive oxygen species (ROS) levels blood lymphocytes, monocytes, granulocytes, along with plasma lipid peroxidation markers total antioxidant capacity, were measured. Fibrinogen structure was examined using circular dichroism spectroscopy intrinsic fluorescence, while properties evaluated by analyzing thrombin-mediated polymerization plasmin-induced lysis. Compared exhibited ROS production systemic stress, leading notable oxidation alterations. These associated impaired fibrin enhanced resistance lysis, which are indicative pro-thrombotic state. findings suggest that stress-driven modifications may contribute heightened thrombotic EM, highlighting therapeutic target mitigate cardiovascular complications.

Language: Английский

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Impact of Sport on the Course of Endometriosis

Quality in Sport, Journal Year: 2024, Volume and Issue: 35, P. 56300 - 56300

Published: Dec. 13, 2024

Endometriosis is a common condition affecting approximately 10% of women reproductive age and leads to many unpleasant symptoms, such as pelvic pain, painful intercourse, fertility issues. Although treatment primarily involves surgical hormonal approaches, growing evidence suggests that physical activity may play beneficial role in alleviating symptoms the disease. The aim this paper review literature on impact endometriosis evaluate exercise improving quality life for patients. Available research indicates regular activity, including aerobic strength exercises, can reduce pain intensity, improve well-being, decrease need medications. Additionally, positively affects mental health, reducing stress, anxiety, depression, which, turn, improves course findings suggest should be considered an integral part treatment, serving supportive therapeutic approach. However, further controlled studies long-term observations are necessary determine optimal type, frequency with endometriosis.

Language: Английский

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Therapeutic Significance of NLRP3 Inflammasome in Cancer: Friend or Foe?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13689 - 13689

Published: Dec. 21, 2024

Besides various infectious and inflammatory complications, recent studies also indicated the significance of NLRP3 inflammasome in cancer progression therapy. NLRP3-mediated immune response pyroptosis could be helpful or harmful cancer, depend on nature tumor microenvironment. The activation increase surveillance efficacy immunotherapy. It can lead to removal cells by recruitment phagocytic macrophages, T-lymphocytes, other site. On hand, harmful, as chronic inflammation driven supports creating an environment that facilitates cell proliferation, migration, invasion, metastasis. release pro-inflammatory cytokines such IL-1β IL-18 promote growth angiogenesis, while sustained may suppression, hindering effective anti-tumor responses. In this review article, we discuss role inflammasome-mediated pathophysiology types; understanding is essential for development innovative therapeutic strategies spread.

Language: Английский

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