Early pregnancy associations with Gestational Diabetes: methods and cohort results of the Hoosier Moms Cohort DOI Creative Commons
David M. Haas,

Hani Faysal,

Mitchell Grecu

et al.

North American Proceedings in Gynecology & Obstetrics, Journal Year: 2024, Volume and Issue: 3(3)

Published: July 27, 2024

Background Gestational Diabetes (GDM) raises the risk of adverse perinatal outcomes and long-term type 2 diabetes. There is currently a lack comprehensive GDM prediction models based on more than simple clinical features. Objective The objective this study was to collect set clinical, sociodemographic, biobehavioral, genomic features in prospective high-risk cohort for GDM, discover novel predictive therapeutic targets during early pregnancy. Study design Hoosier Moms Cohort observational pregnant individuals, with singleton gestation <20 weeks. protocol included visits pregnancy one at delivery. Psychosocial, dietary, social, demographic characteristics were collected addition maternal newborn samples. Developing primary outcome. Univariate associations continuous variables analyzed using either two-sample t-test or Wilcoxon Rank Sum test, categorical chi-square Fishers exact test. Multiple logistic regression performed independent GDM. Results A total 411 participants recruited, complete data available 391. Patients average 30 years age, had mean body mass index (BMI) 28, 17% Hispanic ethnicity. Additionally, 54% reported family history diabetes, 4% reporting personal prior 39 (10.0%) developed Compared those that did not, who significantly higher baseline BMI (31.6 vs 27.2, p=0.003), HbA1c (5.24 5.07, p<0.001), triglycerides (156.8 134.2, p=0.022), random blood glucose (85.90 79.96, p=0.025) initial visit. Those likely have gestational diabetes (28.21% 1.96%, current chronic hypertension (12.82% 1.9%, p=0.003). they scored validated insomnia questionnaire (9.62 7.80, p=0.028). significant association found between 3 previously genetic markers (p<0.01). Individuals high polygenic scores not diagnosis. Through stepwise regression, diagnosis hypertension, insomnia, independently associated (odds ratio, 95% confidence intervals: 14.98, 4.49-50.02; 10.94, 2.32-51.69; 1.11, 1.01-1.22; 1.09, 1.03-1.16, respectively). Conclusion identified previous diagnosis, elevated BMI, increased odds developing diverse participants. These factors will be integrated into machine learning model multi-omics develop predictor

Language: Английский

Care plan for individuals at risk for preeclampsia: shared approach to education, strategies for prevention, surveillance, and follow-up DOI Creative Commons
James M. Roberts, Tekoa L. King,

John R. Barton

et al.

American Journal of Obstetrics and Gynecology, Journal Year: 2023, Volume and Issue: 229(3), P. 193 - 213

Published: April 27, 2023

Preeclampsia is a multisystemic disorder of pregnancy that affects 250,000 pregnant individuals in the United States and approximately 10 million worldwide per annum. associated with substantial immediate morbidity mortality but also long-term for both mother offspring. It now clearly established low dose aspirin given daily, beginning early modestly reduces occurrence preeclampsia. Low-dose seems safe, because there paucity information about effects on infant, it not recommended all individuals. Thus, several expert groups have identified clinical factors indicate sufficient risk to recommend low-dose preventive therapy. These may be complemented by biochemical and/or biophysical tests either increased probability preeclampsia factors, or more importantly, identify likelihood those without other evident risk. In addition, opportunity exists provide this population additional care prevent mitigate short- Patient provider education, surveillance, behavioral modification, approaches improve outcomes these can chance healthy outcome. We assembled group diverse, relevant expertise (clinicians, investigators, advocates, public private stakeholders) develop plan which providers at work together reduce morbidities. The moderate high developing preeclampsia, receive therapy, as laboratory findings. recommendations are presented using GRADE methodology quality evidence upon each based. printable appendices concise summaries plan's patients healthcare provided. believe shared approach will facilitate prevention its attendant development disorder.

Language: Английский

Citations

27

An RCT META analysis based on the effect of tai chi exercise therapy on the outcome of elderly patients with moderate-to-severe sleep disorders-A systematic review study DOI Creative Commons
Lujia Li, Xiaozheng Li,

Yuerong Huang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24085 - e24085

Published: Jan. 1, 2024

BackgroundAccording to statistics, about one-fifth of the world's elderly people suffer from sleep disorders, and problem disorders in is extremely serious, this one important causes chronic diseases such as hypertension, hyperlipidemia, diabetes mellitus, coronary heart disease elderly. The positive effect Tai Chi exercise therapy on problems has been confirmed, but at present, specific duration improvement with moderate severe varies.ObjectiveMETA analysis was used investigate find that long-term best improving patients disorders. Methods: META performed using Revman 5.3 after searching Web science, Pubmed, Scopus, Cochroae Library, OVID, CBM, CNKI, VIP, other databases, then filtering extracting.ResultsA total seven papers were included. Meta-analysis showed tai chi more effective compared control group, difference significant. This demonstrated by a decrease global Pittsburgh Sleep Quality Index (PSQI) score [SMD = −0.66, 95 % CI (−0.91, −0.41), P < 0.00001], well its subdomains subjective quality −0.79, (−1.06, −0.52), latency −0.80, (−1.21, −0.40), −0.38, (−0.72, −0.04), 0.03], habitual efficiency −0.58, (−0.84, −0.31), 0.0001], disturbance −0.51, (−0.78, −0.25), 0.00001] daytime dysfunction −0.33, (−0.59, −0.07), 0.01]. Improvement also observed Epworth Sleepiness Scale (ESS) Insomnia Severity (ISI). results optimal frequency for moderately long-term.ConclusionThis study systematically assessed efficacy moderate-to-severe Through meta-analysis relevant randomized controlled trials (RCTs), it aims determine effectiveness compare effects those traditional treatments; analyze safety patient population assess feasibility non-pharmacological therapy; fill research gaps provide comprehensive systematic evidence support. provides practical approach reducing risk medication side older adults offers potentially treatment option, especially who are unable or unwilling use medication. may not only improve sleep, coordination, muscle strength, balance, reduce stress anxiety adults. It helps socialize enhances their social connections emotional suggests community centers activity can organize classes promote participation adults, be scientific rehabilitation tool clinical treatment, incorporating practice into daily life, fixed time every day week, which improves overall life.

Language: Английский

Citations

6

A Scientometric Review of Obstructive Sleep Apnea and Obesity DOI Creative Commons
Michelle Jin Yee Neoh, Alessandro Carollo, Mengyu Lim

et al.

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(2), P. 753 - 753

Published: Jan. 5, 2023

Obstructive sleep apnea (OSA) is a common disorder that has high prevalence in the obese population. Studies have established relationship between OSA and multitude of adverse health outcomes including cardiovascular diseases metabolic diseases, indicating nature as with comorbidity mortality. Thus, growing public concern face rising obesity trends globally. This study conducted systematic analysis scientific literature on from 1977 to 2022 order gain better understanding major research areas concerning connections these areas. Findings indicate there are clusters investigating which conditions commonly associated significant disease burden. The findings this scientometric also emerging into more specific populations such children pregnant women.

Language: Английский

Citations

10

Construction and validation of a predictive model for sleep disorders among pregnant women DOI Creative Commons
Deguang Yang, Ye Li, Jing Jia

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 6, 2025

Sleep disorders are among the most common major problems during pregnancy. Most studies on sleep of pregnant women closely related to adverse birth outcomes. In this study, our aim was develop and validate a predictive model for risk in women. A total 2,467 healthy were enrolled randomly partitioned into training set validation at ratio 7:3. During variable selection stage, Pearson's chi-square test employed identify variables with p-value below 0.05, which then designated as candidate subsequent logistic regression analysis. Concurrently, LASSO technique utilized sift through isolate valuable variables. Ultimately, we developed binary Logistic models predicated (Model 1) 2). The performance nomograms evaluated using Bootstrap resampling procedure, sensitivity specificity receiver-operating characteristic (ROC), area under ROC curve (AUC), decision analysis (DCA). 439 (25.4%) 208 (28.1%) exhibited disorder, respectively. prediction shared 6 factors (age, anxiety, depression, family functions, degree pregnancy reaction, pre-pregnancy physical condition). Model 1, 69.4%, 59.6%. When weeks, residence, only child included 2, 82.4% 54.8%. set, areas 1 2 0.678 (0.635, 0.720), 0.719 (0.678, 0.761), showed that calibration is approximately distributed along reference line. Decision analyses demonstrated favorable net benefit within range threshold probability nomograms. superior performance, can serve convenient reliable tool predicting

Language: Английский

Citations

0

Prenatal Sleep Restriction Altered Learning Ability and Memory Behaviour by Decreasing Hippocampal Synaptic Plasticity in Offspring Mice DOI
Natasha Chitakwa,

Na Chen,

Chuan‐Mu Chen

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 106500 - 106500

Published: April 1, 2025

Language: Английский

Citations

0

Association Between the Dietary Inflammatory Index and Depression in Mid-Pregnancy: Mediating Effect of Sleep Quality DOI Open Access

Z. Y. Zhang,

Cong Huang, Hua Zhang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1434 - 1434

Published: April 24, 2025

Objective: The aim of this study was to assess the association between Dietary Inflammatory Index (DII) and depression in mid-pregnancy mediating effect sleep quality according Edinburgh Postnatal Depression Scale (EPDS). Methods: This a cross-sectional conducted 2017–2019 at maternal child health centre Hunan Province. After applying inclusion exclusion criteria, 749 pregnant women were finally included study. A multifactorial logistic regression model used estimate odds ratio (OR) 95% confidence interval (95% CI) DII on depression. Restricted cubic spline plot analyse nonlinearity Mediation effects models role quality. Results: average age 29.42 ± 4.22 years. mean 0.21 1.48 overall presenting rate 9.35%. In final adjusted for covariates such as age, race, body mass index (BMI), occupation, literacy, monthly income, risk Q3 3.51 times higher than Q4 [OR = 3.51, CI (1.45 8.53)]. high factor (p < 0.05). analyses showed that could not be considered nonlinear. Sleep may play (25.26% total effect). Conclusions: is can influence only directly but also indirectly through

Language: Английский

Citations

0

Pregnant women’s sleep quality and its associated factors among antenatal care attendants in Bahir Dar City, Northwest Ethiopia DOI Creative Commons

Samuel Awlachew,

Assefa Desalew, Usmael Jibro

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 4, 2025

Good sleep quality is crucial for health and body equilibrium, particularly during pregnancy, where changes in are influenced by mechanical hormonal factors. Poor can hinder daily activities lead to adverse pregnancy outcomes. Data on scarce low middle-income countries such as Ethiopia. Hence, this study aimed determine the magnitude of its associated factors among pregnant mothers Bahir Dar City, northwest A facility-based cross-sectional was conducted with 367 randomly selected women. All women who attended public facilities City from November 1st December 30, 2022 were included except critically ill aged less than 18 years. The data collected through face-to-face interviews. Sleep assessed using Pittsburgh Quality Index (PSQI). Stata v14 used analysis. binary logistic regression model identify poor quality. Statistical significance set at p < 0.05. prevalence 55.04%. In multivariable analysis, older maternal age (AOR = 3.62), third trimester 2.83), multigravidas 2.55), hemoglobin 1.92), coffee consumption 2.19) More half had Women ≥ 30 years, 3rd trimester, multigravidas, anemic women, concerned should pay attention improving Hgb level iron/folate supplementation reduce intake improve pregnancy.

Language: Английский

Citations

0

Continuous Positive Airway Pressure Treatment and Hypertensive Adverse Outcomes in Pregnancy DOI Creative Commons
Yi‐Chieh Lee, Yun‐Chen Chang,

Liang-Wei Tseng

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(8), P. e2427557 - e2427557

Published: Aug. 13, 2024

Importance Pregnancy may contribute to the development or exacerbation of obstructive sleep apnea (OSA) and increase risk gestational complications. Continuous positive airway pressure (CPAP) is first-line criterion standard treatment for OSA regarded as most feasible choice during pregnancy. However, association between CPAP therapy in pregnant women with reduced complications remains inconclusive. Objective To investigate reduction adverse hypertensive outcomes gestation. Data Sources Keyword searches PubMed, Embase, Cochrane Database Systematic Reviews Clinical Trials were conducted from inception November 5, 2023. Study Selection Original studies reporting effect use on lowering hypertension preeclampsia risks selected. Extraction Synthesis The Preferred Reporting Items Meta-Analyses (PRISMA) guideline was followed reviews. independently extracted by 2 authors. Random-effects model meta-analyses performed ratios (RRs) reported. Subgroup analysis, meta-regression based age body mass index (BMI; calculated weight kilograms divided height meters squared), publication bias assessment also conducted. Main Outcome Measures primary outcome RR receiving those who did not receive treatment. Results Six original 809 participants (mean age, 31.4 years; mean BMI, 34.0) identified systematically reviewed meta-analysis. pooled results showed significant differences intervention (CPAP use) control (non-CPAP groups reducing (RR, 0.65; 95% CI, 0.47-0.89; P = .008) 0.70; 0.50-0.98; .04). Meta-regression revealed that patients’ (coefficient, −0.0190; .83) BMI −0.0042; .87) correlated preeclampsia. Conclusions Relevance These findings suggest implementing reduce

Language: Английский

Citations

3

Sleep quality disparities in different pregnancy trimesters in low- and middle-income countries: a systematic review and meta-analysis DOI Creative Commons
Esuyawkal Mislu, Henok Kumsa, Shimelis Tadesse

et al.

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 1, 2024

Language: Английский

Citations

3

Obstructive sleep apnea in pregnancy: A review of the literature from the obstetrics practitioner’s view and a proposed clinical approach DOI

Sophie Farid,

Mackenzie Giunio-Zorkin,

Danny J. Schust

et al.

European Journal of Obstetrics & Gynecology and Reproductive Biology, Journal Year: 2024, Volume and Issue: 300, P. 29 - 34

Published: July 4, 2024

Language: Английский

Citations

2