The last word on COVID-19 vaccines and breastfeeding? DOI Creative Commons
Andrea Balduit, Roberta Bulla, Chiara Agostinis

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 97, P. 104830 - 104830

Published: Oct. 12, 2023

More than two years have now elapsed since the COVID-19 vaccination was first authorized and administered worldwide. Over time, evidence on vaccines has been continuously reviewed by regulatory bodies leading to progressive inclusion of even more susceptible groups (i.e., infants, pregnant breastfeeding women). The initial lack consensus, in concert with absence any preliminary data about mRNA vaccine transfer persistence breast milk (BM), determined hesitancy low compliance among mothers. In this issue eBioMedicine, Hanna colleagues attempted put final word biodistribution, fragmentation biological activity BM.1Hanna N. Manzano de Mejia C. Heffes-Doon A. et al.Biodistribution human milk.EBioMedicine. 2023; 96104800https://doi.org/10.1016/j.ebiom.2023.104800Summary Full Text PDF PubMed Scopus (0) Google Scholar They demonstrated that does not persist injection site but can be systemically spread, being mainly packaged into BM extracellular vesicles (EVs). addition, they definitively reported presence BM, although displaying large very little translational activity. Recent scientific literature focused determining functionality anti-Spike protein antibodies vaccinated women,2Rosenberg-Friedman M. Kigel Bahar Y. al.BNT162b2 elicited antibody response blood women.Nat Commun. 2021; 12: 6222Crossref (30) Scholar,3Agostinis Toffoli Balduit al.Anti-spike present SARS-CoV-2 mothers are complement-activating.Int J Mol Sci. 24: 4395Crossref (2) only few studies investigated levels BNT162b2 or mRNA-1273 BM.4Shook L.L. Edlow A.G. Safety efficacy coronavirus disease 2019 (COVID-19) during lactation.Obstet Gynecol. 141: 483-491Crossref (5) Golan al., analyzing 13 samples collected from 7 women 24 h after -including multiple time points, up 48 h, a single participant-have initially neglected vaccine-associated mRNA.5Golan Prahl Cassidy al.Evaluation messenger RNA BTN162b2 milk.JAMA Pediatr. 175: 1069-1071Crossref (35) Low al. instead minimal at sub-picogram level approximately 10% BM: highest concentration detected 2 ng/mL, which would consistent 0.667% original dose 100 mL BM.6Low J.M. Gu Ng M.S.F. al.Codominant IgG IgA expression vaccinees.NPJ Vaccines. 6: 105Crossref (44) Yeo also transient intact 5/309 (2%) samples, serum breastfed infants.7Yeo K.T. Chia W.N. Tan C.W. al.Neutralizing breastmilk lactating women.Front Immunol. 12783975Google It is worthwhile mention limited sample sizes, sensitivity techniques storage may significant impact results these studies. ultimate convincing for precisely study 154 were individuals different intervals and/or booster dose.1Hanna group small amounts 15 post-injection. Interestingly, provided packaging EVs isolated supernatants, as previously anticipated same group,8Hanna Lin X. al.Detection 2022; 176: 1268-1270Crossref (19) approximatively 12–90% found EV fraction. Similar findings paved way proposal new model biodistribution intramuscular injection, lipid nanoparticles enclosing diffuse mammary glands via hematic lymphatic pathways; within cells, developing released BM. surprising researchers working nanoparticles, off-target distribution major formulations last decade.9Carrasco M.J. Alishetty S. Alameh M.G. al.Ionization structural properties influence intravascular administration.Commun Biol. 4: 956Crossref (92) authors moved step further other previous publications field exploring potential integrity mRNA. Assuming EVs, resistant gastric pancreatic digestion retain capability enter intestinal cells vitro,10Liao Du Li J. Lönnerdal B. Human exosomes their microRNAs survive vitro taken cells.Mol Nutr Food Res. 2017; 61https://doi.org/10.1002/mnfr.201700082Crossref (209) decisive breakthrough consists demonstration residual unable induce Spike EV-treated HT-29 cells. This likely due poor it reduced 12–25% duplex droplet digital PCR (ddPCR) using probes targeting flanks vaccine. We like particularly point out had great merit overcoming some technical limitations research, ddPCR linkage assays, use distinct set primers allowed specific sensitive respective mRNAs. should keep mind detection synonymous harm, suggested its scarce benefits maternal lactation mother-infant dyad outweigh conceivable hazards, accordance recommendations governmental health agencies. accumulating evidence, particular emerging current study, allows us reasonably assert danger newborns is, say least, remote; however, safety needed shed light fate BM-derived infant's body provide still controversial issue. Andrea Chiara Agostinis: conceptualization draft preparation. Roberta Bulla: review editing. declare no conflict interest. work supported Italian Ministry Health, through contribution given Institute Maternal Child Health IRCCS Burlo Garofolo-Trieste, Italy.

Language: Английский

Biodistribution of RNA Vaccines and of Their Products: Evidence from Human and Animal Studies DOI Creative Commons

Ildus Pateev,

Kristina Seregina,

Roman Ivanov

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 12(1), P. 59 - 59

Published: Dec. 26, 2023

Explosive developments in mRNA vaccine technology the last decade have made it possible to achieve great success clinical trials of vaccines prevent infectious diseases and develop cancer treatments mRNA-based gene therapy products. The approval mRNA-1273 BNT162b2 against SARS-CoV-2 by U.S. Food Drug Administration has led mass vaccination (with vaccines) several hundred million people around world, including children. Despite its effectiveness fight COVID-19, rare adverse effects been shown some studies, vascular microcirculation disorders autoimmune allergic reactions. biodistribution remains one most poorly investigated topics. This mini-review discussed results recent experimental studies on humans rodents regarding vaccines, their constituents (mRNA lipid nanoparticles), encoded antigens. We focused dynamics products possibility crossing blood–brain blood–placental barriers as well transmission infants through breast milk. In addition, we critically assessed strengths weaknesses detection methods that applied these articles, whose results’ reliability is becoming a subject debate.

Language: Английский

Citations

22
Factors Associated with Anti-SARS-CoV-2 Vaccine Acceptance among Pregnant Women: Data from Outpatient Women Experiencing High-Risk Pregnancy DOI Creative Commons
Marianna Maranto, Giuseppe Gullo, Alessandra Nejar Bruno

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 454 - 454

Published: Feb. 16, 2023

Pregnant women are at higher risk of severe Coronavirus disease 2019 (COVID-19) complications than non-pregnant women. The initial exclusion pregnant from anti-SARS-CoV-2 vaccines clinical trials has caused a lack conclusive data about safety and efficacy for this vulnerable population. This cross-sectional study aims to define the factors related vaccination adherence in sample experiencing high-risk pregnancies. recruited completed questionnaire based on Health Belief Model. Data were analyzed evaluate associations between socio-demographic variables acceptance through descriptive, univariate multivariate logistic analyses. Among 233 enrolled, 65.2% (n = 152) declared that they would accept vaccine. Multivariate analysis showed was associated with high educational level (aOR 4.52, p 0.001), low perception barriers 1.58, 0.005) gynecologist’s advice 3.18, 0.01). About third still hesitant vaccine, probably because conflicting information received media, friends, acquaintances health institutions. Determining linked vaccine hesitancy among is useful creating strategies increase uptake.

Language: Английский

Citations

17
EudraVigilance insights: Suspected adverse drug reactions in infants through breastfeeding DOI Creative Commons
Ida M. Heerfordt, Ditte Resendal Gotfredsen, Henrik Horwitz

et al.

British Journal of Clinical Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

Aims We aimed to describe suspected adverse drug reactions (ADRs) in infants resulting from medications transmitted through mothers' milk, as reported the European ADR database, EudraVigilance. The research sought understand frequency, seriousness and nature of these ADRs assess potential risks associated with maternal medication use during breastfeeding. Methods Data EudraVigilance were analysed. study included all be related milk 1 January 2013 July 2023. data categorized by reporting time, infant age sex, type ADR, involved. Results A total 922 breastfed infants. Serious accounted for 133 cases (14%), 15 fatalities, primarily methadone ( n = 11) diamorphine 3). COVID‐19 vaccines linked half reports 479, 52%), while serious mainly nervous system drugs 73, 43%), particularly anticonvulsants opioids. Most 511, 55%) occurred aged between month year. Conclusions over a decade, compared estimated millions exposed via annually Europe, suggests very low rate ADRs. This finding emphasizes significant challenges postmarketing surveillance that underreporting remains critical concern pharmacovigilance.

Language: Английский

Citations

0
Determinants of Vaccination and Willingness to Vaccinate against COVID-19 among Pregnant and Postpartum Women during the Third Wave of the Pandemic: A European Multinational Cross-Sectional Survey DOI Creative Commons
Émeline Maisonneuve, Eva Gerbier, Fatima Tauqeer

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(5), P. 1090 - 1090

Published: April 29, 2023

With COVID-19 vaccination hesitancy at around 50% in the obstetric population, it is critical to identify which women should be addressed and how. Our study aimed assess willingness among pregnant postpartum Europe investigate associated determinants. This was a cross-sectional, web-based survey conducted Belgium, Norway, Switzerland, The Netherlands, United Kingdom (UK) June–August 2021. Among 3194 women, proportions of vaccinated or willing ranged from 80.5% Belgium 21.5% Norway. characteristics were country residence, chronic illness, history flu vaccine, trimester pregnancy, belief that more severe during vaccine effective safe pregnancy. 1659 86.0% UK 58.6% Switzerland. determinants breastfeeding, breastfeeding. Vaccine population depends on medical especially opinion residence.

Language: Английский

Citations

7
Vaccine Hesitancy in Women’s Health DOI

Benjamin Spires,

Annabeth Brewton,

Jill M. Maples

et al.

Obstetrics and Gynecology Clinics of North America, Journal Year: 2023, Volume and Issue: 50(2), P. 401 - 419

Published: May 4, 2023

Language: Английский

Citations

5
Newborns at risk of COVID-19, the story continues DOI Creative Commons
Malika D. Shah, Nicholas Miller, Ola Didrik Saugstad

et al.

Journal of Perinatal Medicine, Journal Year: 2024, Volume and Issue: 52(6), P. 567 - 574

Published: May 14, 2024

After more than 4 years of the SARS-CoV-2 pandemic, a great deal knowledge on how this virus affects pregnant women, fetus and newborn has accumulated. Guidelines for mode delivery, cord clamping, skin to skin, breastfeeding, rooming-in have become uniform across world. Vaccination considerably improved outcomes, but hesitancy amongst patients emergence variants remain challenged positivity during pregnancy continues be associated with an increased risk maternal complications, premature delivery higher neonatal mortality morbidity. An emerging body data now exists effect in early medical education obstetrics pediatrics, longer-term developmental outcomes. In article, we review development field since our last review.

Language: Английский

Citations

1
Persistence and Efficacy of Maternal COVID-19 Vaccine-Induced Antibodies in Human Milk: A Comprehensive Meta-Analysis DOI Creative Commons

Neha Fatima,

Syeda Nawal Fatima,

Nisha Noor

et al.

Developmental medico-life-sciences, Journal Year: 2024, Volume and Issue: 1(2), P. 8 - 19

Published: May 28, 2024

Abstract Background: The ongoing global health challenge posed by the COVID-19 pandemic has necessitated a thorough examination of vaccine efficacy, particularly transfer vaccine-induced immunity to infants via human milk. This meta-analysis aims explore persistence and efficacy antibodies in milk, offering insights into passive breastfeeding infants. Methods: We conducted systematic review peer-reviewed studies published from January 2021 December 2023, extracted databases such as PubMed, Scopus, Web Science. Our focus was on measuring SARS-CoV-2-specific (IgA IgG) milk following maternal vaccination. Results: Fifteen involving 1,200 lactating mothers who received mRNA vaccines were included. analysis highlighted consistent presence IgA IgG persisting for up six months post-vaccination. Conclusion: results highlight noteworthy transmission suggesting an extended duration possible protection neonates against SARS-CoV-2 infection. argues favor immunizing nursing preemptive public strategy provide their children immunity.

Language: Английский

Citations

1
Factors Associated With Coronavirus Disease 2019 Vaccine Uptake Among Pregnant Women and Nonpregnant Women of Reproductive Age in Jamaica DOI Creative Commons
Jodian Pinkney, Laura M. Bogart, Kamali Carroll

et al.

Open Forum Infectious Diseases, Journal Year: 2023, Volume and Issue: 10(5)

Published: April 13, 2023

Abstract Background Despite high rates of coronavirus disease 2019 (COVID-19)-related maternal mortality, Jamaica currently has little data on COVID-19 vaccine uptake among pregnant women. Methods We conducted a cross-sectional, web-based survey 192 reproductive-aged women in from February 1 to 8, 2022. Participants were recruited convenience sample patients, providers, and staff at teaching hospital. assessed self-reported vaccination status COVID-19-related medical mistrust (operationalized as confidence, government mistrust, race-based mistrust). used multivariable modified Poisson regression test the association between pregnancy. Results Of respondents, 72 (38%) pregnant. Most (93%) Black. Vaccine was 35% versus 75% nonpregnant Pregnant more likely cite healthcare providers trustworthy sources information (65% vs 28%). Pregnancy, low associated with lower likelihood (adjusted prevalence ratio [aPR] = 0.68 [95% confidence interval {CI}, .49–.95], aPR 0.61 CI, .40–.95], .52–.89], respectively). Race-based not final model. Conclusions Jamaica. Future studies should evaluate efficacy strategies proven improve coverage, including standing “opt-out” orders collaborative provider patient-led educational videos tailored for individuals. Strategies that decouple messaging agencies also warrant evaluation.

Language: Английский

Citations

2
COVID-19 vaccination for patients with epilepsy: A Chinese expert consensus DOI
Xuewu Liu, Qun Wang, Liankun Ren

et al.

Epilepsy & Behavior, Journal Year: 2023, Volume and Issue: 147, P. 109387 - 109387

Published: Aug. 23, 2023

Language: Английский

Citations

2
Comparative analysis of the effectiveness difference of SARS-COV-2 mRNA vaccine in different populations in the real world: A review DOI Creative Commons
Sihui Cai, Chunyan Chang, Xiuhong Zhang

et al.

Medicine, Journal Year: 2023, Volume and Issue: 102(34), P. e34805 - e34805

Published: Aug. 25, 2023

Coronavirus disease 2019 (COVID-19) has ravaged the world since December 2019. Up to now, it is still prevalent around world. Vaccines are an important means prevent spread of COVID-19 and reduce severe mortality. Currently, different types novel coronavirus vaccines being developed improved, relevant that have been approved for marketing widely vaccinated As vaccination coverage continues grow, concerns about efficacy safety after real-world use grown. Some clinical studies shown vaccine effectiveness closely related antibody response vaccination. Among them, advantages messenger ribonucleic acid (mRNA) vaccine, such as better adaptability variant strains immune ability, attracted great attention. However, populations with genders, ages, previous infection history, underlying diseases treatments will show responses mRNA vaccination, which affect protection vaccine. Based on this, this paper reviews reports acute respiratory syndrome 2 vaccines, summarizes in states looked forward precise strategy future.

Language: Английский

Citations

2