Long-Term Response to SARS-CoV-2 mRNA Vaccine in Adolescents

The Pediatric Infectious Disease Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Background: The COVID-19 pandemic’s transition to an endemic phase emphasizes the importance of vaccination. Despite initial strong immunogenicity, waning vaccine-induced immunity requires further investigation. Therefore, this study evaluated immunogenicity BNT162b2 vaccine in adolescents, focusing on spike-specific and neutralizing antibody kinetics following primary booster vaccinations as well impact breakthrough infections. Methods: This observational included 157 adolescents 12–17 years old who received 22 participants doses. Antibody levels were measured at 1, 3, 5 10 months post-vaccination post-booster. Breakthrough infections identified using SARS-CoV-2 antigen/polymerase chain reaction tests. Safety was monitored by tracking adverse effects. Results: Post-primary vaccination, geometric mean titer anti-spike antibodies decreased significantly over time, with a 2.3-fold reduction after months. Booster doses induced higher titers, which also waned albeit more slowly. boosted including those against variants such Delta Omicron. Long-term effects minimal, only 7 cases transient lymph node enlargement menstrual irregularities. Conclusions: robust immune responses adolescents; however, time. are essential for sustained protection, especially emerging variants. enhance responses, highlighting benefits hybrid immunity. safety profile is generally favorable; ongoing monitoring warranted.

Language: Английский

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Menstrual Cycle Length Changes Following Vaccination Against Influenza Alone or With COVID-19

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(4), P. e257871 - e257871

Published: April 29, 2025

Multiple studies have identified an association between COVID-19 vaccination and menstrual disturbances. Data on whether health is impacted by other vaccines are needed to counsel individuals about what expect address vaccine hesitancy. To assess the of changes in length cycle with influenza vaccination, or without concurrent receipt a vaccine. This global retrospective cohort study prospectively collected data from April 25, 2023, February 27, 2024 (4-5 cycles per individual), among international English-speaking users digital birth control application. Participants included aged 18 45 years, not using hormonal contraception, average lengths 24 38 days 3 consecutive before vaccines. Seasonal The primary outcome consisted adjusted mean within-individual assessed group. Secondary analysis evaluated phase at time vaccination. A total 1501 met inclusion criteria, whom 791 were vaccinated for only 710 concurrently COVID-19. By race ethnicity, 1 participant (0.1%) was American Indian Alaska Native; 10 (0.7%), Asian; (0.2%), Black; 15 (1.0%), Hispanic Latina; (0.1%), Middle Eastern North African; 368 (24.5%), White; 19 (1.3%), other; 1084 (72.2%), missing. Most younger than 35 years (1230 [82.0%]), had least college degree (1122 [74.8%]), located US Canada (938 [62.5%]). Individuals alone experienced increase 0.40 (95% CI, 0.08-0.72) days, while those 0.49 0.16-0.83) (P = .69 difference groups). 37 (4.7%) change 8 42 (5.9%) both .28). In postvaccination cycle, groups returned their prevaccination lengths. Menstrual occurred follicular but luteal phase. this regular cycles, given combination associated small temporary length. These findings may help clinicians confirm utility patients concerns adverse effects

Language: Английский

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Menstruation as the Next Vital Sign

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(5), P. e2412778 - e2412778

Published: May 29, 2024

Zifan Wang, PhD, MS; Gowtham Asokan, Jukka-Pekka Onnela, DSc; Donna D. Baird, PhD; Anne Marie Z. Jukic, MSPH; Allen J. Wilcox, MD, Christine L. Curry, Tyler Fischer-Colbrie, MBA; Michelle A. Williams, ScD; Russ Hauser, ScD, MPH; Brent Coull, Shruthi Mahalingaiah, MS

Language: Английский

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Susceptibility to Infection and Impact of COVID-19 Vaccines on Symptoms of Women with Endometriosis: A Systematic Review and Meta-Analysis of Available Evidence

Reproductive Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

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In Reply:

Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 144(1), P. e12 - e13

Published: June 20, 2024

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Timing of Coronavirus Disease 2019 (COVID-19) Vaccination and Effects on Menstrual Cycle Changes

Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 144(1), P. e10 - e12

Published: June 20, 2024

Language: Английский

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