Pharmaceutical Research, Journal Year: 2023, Volume and Issue: 40(11), P. 2585 - 2596
Published: Aug. 23, 2023
Language: Английский
Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(2), P. 173 - 190
Published: Jan. 19, 2024
Citations
16
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 4, 2025
Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.
Language: Английский
Citations
3
Cancer and Metastasis Reviews, Journal Year: 2023, Volume and Issue: 43(2), P. 673 - 708
Published: Dec. 1, 2023
Abstract Hepatocellular carcinoma (HCC) is an increasing burden on global public health and associated with enhanced lipogenesis, fatty acid uptake, lipid metabolic reprogramming. De novo lipogenesis under the control of transcription factor sterol regulatory element-binding protein 1 (SREBP-1) essentially contributes to HCC progression. Here, we summarize current knowledge regulation SREBP-1 isoforms in based cellular, animal, clinical data. Specifically, (i) address overarching mechanisms for regulating transcription, proteolytic processing, nuclear stability, transactivation (ii) critically discuss their impact HCC, taking into account (iii) insights from pharmacological approaches. Emphasis placed cross-talk phosphatidylinositol-3-kinase (PI3K)-protein kinase B (Akt)-mechanistic target rapamycin (mTOR) axis, AMP-activated (AMPK), A (PKA), other kinases that directly phosphorylate SREBP-1; factors, such as liver X receptor (LXR), peroxisome proliferator-activated receptors (PPARs), γ co-activator (PGC-1), signal transducers activators (STATs), Myc; epigenetic mechanisms; post-translational modifications SREBP-1-regulatory metabolites oxysterols polyunsaturated acids. By carefully scrutinizing role development, progression, metastasis, therapy resistance, shed light potential SREBP-1-targeting strategies prevention treatment.
Language: Английский
Citations
35
Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(10), P. 822 - 840
Published: July 18, 2024
Language: Английский
Citations
13
Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111589 - 111589
Published: Jan. 5, 2025
Language: Английский
Citations
1
Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(7)
Published: March 27, 2025
ABSTRACT Background Within the tumor microenvironment, cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in extracellular milieu. Furthermore, within this microenvironment influences immune landscape tumors, facilitating evasion consequently promoting tumorigenesis. These biological involve modifications numerous enzymes associated with uptake synthesis, including NPC1L1, SREBP, HMGCR, SQLE, PCSK9. Review This review systematically summarizes role metabolism its cancer progression, examines mechanisms through which dysregulation affects discusses recent advancements therapies that target metabolism. Conclusion Targeting metabolism‐related can inhibit growth, reshape landscapes, rejuvenate antitumor immunity, offering potential therapeutic avenues treatment.
Language: Английский
Citations
1
Cancers, Journal Year: 2023, Volume and Issue: 15(12), P. 3161 - 3161
Published: June 13, 2023
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related deaths worldwide. There has been significant progress in understanding risk factors and epidemiology HCC during last few decades, resulting efficient preventative, diagnostic treatment strategies. Type 2 diabetes mellitus (T2DM) demonstrated to be a major factor for developing HCC. Metformin widely used hypoglycemic agent patients with T2DM shown play potentially beneficial role improving survival Experimental clinical studies evaluating outcomes metformin as an antineoplastic drug setting were reviewed. Pre-clinical evidence suggests that may enhance antitumor effects immune checkpoint inhibitors (ICIs) reverse effector T cells' exhaustion. However, there still limited regarding efficacy combination ICIs We appraised analyzed vitro animal aimed elucidate mechanisms action metformin, well assessed its impact on patients.
Language: Английский
Citations
19
Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 327 - 346
Published: Feb. 1, 2024
Abstract: Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving prognosis HCC remains formidable challenge. It is noteworthy that lipid metabolism plays pivotal role onset, development, progression cells. Existing research indicates potential application targeting HCC. This review aims to thoroughly explore alterations HCC, offering detailed account advantages associated innovative therapeutic strategies metabolism. Targeting holds promise for potentially enhancing Keywords: cholesterol, fatty acid, hepatocellular carcinoma, uptake, catabolism, synthesis
Language: Английский
Citations
6
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 4, 2024
Abstract Hepatocellular carcinoma (HCC), an aggressive malignancy with a dismal prognosis, poses significant public health challenge. Recent research has highlighted the crucial role of lipid metabolism in HCC development, enhanced synthesis and uptake contributing to rapid proliferation tumorigenesis cancer cells. Lipids, primarily synthesized utilized liver, play critical pathological progression various cancers, particularly HCC. Cancer cells undergo metabolic reprogramming, essential adaptation tumor microenvironment (TME), fatty acid emerging as key player this process. This review delves into intricate interplay between metabolism, focusing on four areas: de novo lipogenesis, oxidation, dysregulated immune TME, therapeutic strategies targeting for treatment.
Language: Английский
Citations
5
Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 3017 - 3017
Published: Aug. 29, 2024
Oral cancer, particularly oral squamous cell carcinoma (OSCC), is a significant global health challenge because of its high incidence and limited treatment options. Major risk factors, including tobacco use, alcohol consumption, specific microbiota, contribute to the disease’s prevalence. Recently, compelling association between diabetes mellitus (DM) cancer has been identified, with metformin, widely used antidiabetic drug, emerging as potential therapeutic agent across various cancers, OSCC. This review explores both preclinical clinical studies understand mechanisms by which metformin may exert anticancer effects, such inhibiting proliferation, inducing apoptosis, enhancing efficacy existing treatments. Preclinical demonstrate that modulates crucial metabolic pathways, reduces inflammation, impacts cellular thereby potentially lowering improving patient outcomes. Additionally, metformin’s ability reverse epithelial-to-mesenchymal transition (EMT), regulate LIN28/let-7 axis, role in head neck (HNSCC) are examined through experimental models. In contexts, shows promise outcomes reducing recurrence rates, although challenges drug interactions, complex dosing regimens, risks vitamin B12 deficiency remain. Future research should focus on optimizing application, investigating synergistic effects other therapies, conducting rigorous trials validate OSCC treatment. dual exploration underscores play transformative management care, revolutionizing strategies.
Language: Английский
Citations
4