Epidemiology of gastrointestinal cancers: a systematic analysis from the Global Burden of Disease Study 2021

Gut, Journal Year: 2024, Volume and Issue: 74(1), P. 26 - 34

Published: Sept. 6, 2024

Gastrointestinal cancers comprise nearly one-third of global mortality from cancer, yet the comprehensive burden these remains uninvestigated.

Language: Английский

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Global epidemiology of alcohol‐associated liver disease in adolescents and young adults

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(3), P. 378 - 388

Published: June 3, 2024

Summary Background and Aims The objective of the study was to analyse prevalence, incidence, death alcohol‐associated liver disease (ALD) among adolescents young adults globally, continentally, nationally, focusing on trends over time. Methods analysed data from Global Burden Disease (GBD) between 2000 2019. It examined ALD's in aged 15–29, segmented by region, nation, sociodemographic index. analysis utilised Joinpoint regression modelling calculate annual per cent change (APC) rate these parameters Results In 2019, there were 281,450 ALD prevalences, 18,930 incidences, 3190 deaths globally. From age‐adjusted prevalence 100,000 increased 25–29 age group (APC: +0.6%, p = 0.003), remained stable ages 20–24 ( 0.302) 15–19 0.160). Prevalence significantly (19‐fold increase) (2.5‐fold increase). rates all groups Africa Eastern Mediterranean region. Around three‐quarters countries territories experienced an increase incidence adults. Conclusion Over two decades, burden has emphasises importance public health policies aimed at reducing alcohol consumption preventing younger populations.

Language: Английский

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Liver diseases: epidemiology, causes, trends and predictions

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 4, 2025

Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.

Language: Английский

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Socio‐economic association of alcohol use disorder and cardiovascular and alcohol‐associated liver disease from 2010 to 2019

Alimentary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 60(3), P. 340 - 349

Published: May 29, 2024

Summary Backgrounds and Aims Alcohol use leads to disabilities deaths worldwide. It not only harms the liver but also causes alcohol disorder (AUD) heart disease. Additionally, consumption contributes health disparities among different socio‐economic groups. Methods We estimated global regional trends in burden of AUD, disease, cardiovascular disease from using methodology Global Burden Disease study. Results In 2019, highest disability‐adjusted life years rate per 100,000 population was due AUD (207.31 [95% Uncertainty interval (UI) 163.71–261.66]), followed by alcohol‐associated (ALD) (133.31 UI 112.68–156.17]). The prevalence decreased for (APC [annual percentage change] −0.38%) alcohol‐induced cardiomyopathy −1.85%) increased ALD 0.44%) cancer 0.53%). Although mortality 0.30%), rates other diseases decreased. Between 2010 complications countries with low low‐middle sociodemographic index (SDI), contributing more significantly burden. Conclusion liver, has been high increasing over past decade, particularly complications. Lower SDI are this There is a pressing need effective strategies address escalating

Language: Английский

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Global epidemiology of early‐onset upper gastrointestinal cancer: trend from the Global Burden of Disease Study 2019

Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 39(9), P. 1856 - 1868

Published: May 21, 2024

Abstract Background and Aim In recent years, there has been a growing incidence of gastrointestinal cancer in young individuals. Despite its significant morbidity mortality, research on upper (UGI) populations relatively limited. Therefore, studies the epidemiological changes this are needed. Methods Using data from Global Burden Disease Study 2019, we examined incidence, death, disability‐adjusted life years (DALYs) UGI cancers young, namely, early‐onset esophageal (EOEC) gastric (EOGC). These results were stratified by sex, geographical region, country, sociodemographic index. Results There was total 185 140 cases, 120 289 deaths, 5.70 million DALYs attributable to globally. From 2010 global rates decreased. contrast, increased both EOEC (+1.15%) EOGC (+0.21%) Eastern Mediterranean region. Conclusions Over past decade, burden However, it Further elucidate risk factors population is warranted.

Language: Английский

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Increased MASH-associated liver cancer in younger demographics

Hepatology Communications, Journal Year: 2025, Volume and Issue: 9(1)

Published: Jan. 1, 2025

Background: The incidence of cancer and the prevalence metabolic disease dysfunction–associated steatotic liver is increasing in young adults. However, updated global data on steatohepatitis (MASH)-associated primary (PLC) adults remains scarce. Methods: This study analyzed from Global Burden Disease between 2000 2021 to assess age-standardized incidence, mortality, disability-adjusted life years rates MASH-associated PLC (15–49 y). Results: In 2021, there were 4300 cases, 3550 deaths, 179,340 Among various etiologies adults, only had increased (annual percent change: +0.26, 95% CI: 0.16%–0.35%), with Eastern Mediterranean region having largest observed increase 1.46%, 1.40%–1.51%). made up 6% (+1% 2000) incident (+2% all this age group. Over half countries exhibited an rate 2021. Conclusions: significantly increasing, signaling likely future increases among older as cohort ages. trend necessitates urgent strategies worldwide mitigate epidemics

Language: Английский

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Hepatocellular carcinoma: updates on epidemiology, surveillance, diagnosis and treatment

Clinical and Molecular Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Hepatocellular carcinoma (HCC) is a major global burden, ranking as the third leading cause of cancer-related mortality.HCC due to chronic hepatitis B virus (HBV) or C (HCV) infection has decreased universal vaccination for HBV and effective antiviral therapy both HCV, but HCC related metabolic dysfunction associated steatotic liver disease (MASLD) alcohol-associated (ALD) increasing.Biannual ultrasonography serum α-fetoprotein are primary surveillance tools early detection among high-risk patients (e.g., cirrhosis, HBV).Alternative such blood-based biomarker panels abbreviated MRIs being investigated.Multiphasic CT MRI standard diagnosis, histological confirmation should be considered, especially when inconclusive findings seen on cross-sectional imaging.Staging treatment decisions complex made in multidisciplinary settings, incorporating multiple factors including tumor degree dysfunction, patient performance status, available expertise, preferences.Early-stage best treated with curative options resection, ablation, transplantation.For intermediatestage disease, locoregional therapies primarily recommended although systemic may preferred large intrahepatic burden.In advanced-stage immune checkpoint inhibitor (ICI)-based regimen.In this review article, we discuss recent epidemiology, risk factors, care continuum encompassing surveillance, staging, treatments.

Language: Английский

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Changes in the epidemiological trends of primary liver cancer in the Asia–Pacific region

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 22, 2024

Primary liver cancer is the third leading cause of cancer-related mortality. The increasing prevalence metabolic syndrome and alcohol consumption, along with existing burden viral hepatitis, could significantly heighten impact primary cancer. However, specific effects these factors in Asia–Pacific region, which comprises more than half global population, remain largely unexplored. This study aims to analyze epidemiology region. We evaluated regional national data from Global Burden Disease spanning 2010 2019 assess age-standardized incidence, mortality, disability-adjusted life years associated During period, there were an estimated 364,700 new cases 324,100 deaths, accounting for 68 67% totals, respectively. Upward trends observed incidence rates due dysfunction-associated fatty disease (MASLD) alcohol-associated (ALD) as well increase Hepatitis B virus infection Western Pacific Notably, approximately 17% occurred individuals aged 15–49 years. Despite overall decline region over past decade, increases noted several etiologies, including MASLD ALD. hepatitis remains cause, responsible 60% total burden. These findings underscore urgent need comprehensive strategies address rising

Language: Английский

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Early-Onset Gastrointestinal Cancers and Metabolic Risk Factors: Global Trends From the Global Burden of Disease Study 2021

Mayo Clinic Proceedings, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Young Adults and Alcohol-Associated Liver Cancer: Incidence and Death from 2000 to 2021

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 609 - 609

Published: Feb. 11, 2025

Background/Objectives: The incidence and mortality of early-onset cancers have been rising in recent decades. While epidemiological studies examined various types cancer, updated global data on alcohol-attributable primary liver cancer (PLC) young adults remains limited. Methods: This study utilized from the Global Burden Disease (GBD) spanning 2000 to 2021 evaluate age-standardized incidence, mortality, corresponding rates PLC among aged 15–49 years. Results: In 2021, there were 8290 cases 6590 deaths adults. rate has increased Europe (annual percent change [APC]: 0.44%, 95%CI 0.35 0.54%), Southeast Asia (APC: 0.40%, 95% CI 0.37 0.44%), Western Pacific region 0.65%, 0.44 0.86%). represented 11% (+2% 2000) incident all About half countries showed an increase between 2021. Conclusions: shifted significantly over past two decades, with notable increases Asia–Pacific region. trend underscores need for strategies address prevalence alcohol use disorder alcohol-associated disease their impact

Language: Английский

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