Comparison of postoperative survival prognosis between early-onset and late-onset esophageal cancer: A Population-based study DOI Creative Commons
Lang Qin, Jie Tian, Yuan Zhang

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0315391 - e0315391

Published: Dec. 12, 2024

The prognosis of non-distant metastatic early-onset esophageal cancer (EC) patients undergoing surgical treatment remains unclear, this study aims to compare the and late-onset EC. Information on EC who underwent were initially diagnosed between 2004 2015 was collected from Surveillance, Epidemiology, End Results (SEER) database. Propensity score matching (PSM) used balance baseline differences patients. Univariate multivariate Cox regression analyses calculate hazard ratio (HR) 95% confidence interval (CI). Kaplan-Meier method log-rank test overall survival (OS) two groups Atotal 5320 included, with 571 in group 4749 group. Multivariate analysis showed that had better OS (HR = 0.732, CI: 0.655-0.819, p<0.001). Using PSM at a 1:1 ratio, we matched 557 After matching, model still favorable for 0.728, 0.630-0.842, Additionally, subgroup indicated long-term prognosis. Non-distant demonstrated outcomes, confirmed by cohort.

Language: Английский

Increased MASH-associated liver cancer in younger demographics DOI Creative Commons
Pojsakorn Danpanichkul,

Yanfang Pang,

Kanokphong Suparan

et al.

Hepatology Communications, Journal Year: 2025, Volume and Issue: 9(1)

Published: Jan. 1, 2025

Background: The incidence of cancer and the prevalence metabolic disease dysfunction–associated steatotic liver is increasing in young adults. However, updated global data on steatohepatitis (MASH)-associated primary (PLC) adults remains scarce. Methods: This study analyzed from Global Burden Disease between 2000 2021 to assess age-standardized incidence, mortality, disability-adjusted life years rates MASH-associated PLC (15–49 y). Results: In 2021, there were 4300 cases, 3550 deaths, 179,340 Among various etiologies adults, only had increased (annual percent change: +0.26, 95% CI: 0.16%–0.35%), with Eastern Mediterranean region having largest observed increase 1.46%, 1.40%–1.51%). made up 6% (+1% 2000) incident (+2% all this age group. Over half countries exhibited an rate 2021. Conclusions: significantly increasing, signaling likely future increases among older as cohort ages. trend necessitates urgent strategies worldwide mitigate epidemics

Language: Английский

Citations

1
Global burden and cross-country health inequalities of early-onset colorectal cancer and its risk factors from 1990 to 2021 and its projection until 2036 DOI Creative Commons
Jinhai Zhang, Dehua Ou,

Aosi Xie

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 12, 2024

To explore the worldwide, regional, and country-specific burden of early-onset colorectal cancer (EO-CRC) identify its associated risk factors between 1990 2021, to project incidence mortality rates for 2036. We acquired data on EO-CRC categorized by gender, socio-demographic index (SDI), based Global Burden Disease (GBD) Study 2021. Joinpoint regression analysis was utilized variation in disease burden. The autoregressive integrated moving average (ARIMA) model performed forecast up Globally, rate, prevalence disability-adjusted life years (DALYs) rate were estimated at 5.37 (95%UI: 4.91 5.86)/100,000, 34 30.96 37.35)/100,000, 2.01 1.84 2.19)/100,000, 101.37 (95%: 92.85 110.18)/100,000 showed an ascending trajectory, whilst DALYs demonstrated a downward trajectory high-middle SDI regions East Asia exhibited highest among five 21 GBD respectively. A low-whole-grains diet chief factor contributing EO-CRC. It predicted that age-standardized (ASR) would increase 5.56%, while ASR decrease 13.9% globally until current future global is heavy varies significantly across different countries.

Language: Английский

Citations

6
Hereditary Gastrointestinal Cancer Syndromes and Early‐Onset Gastrointestinal Cancers DOI
Rashid N. Lui, Han‐Mo Chiu

Journal of Gastroenterology and Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Sex-based analysis of clinical outcomes in elderly patients with esophageal squamous cell carcinoma post-esophagectomy: a propensity score matching analysis DOI Creative Commons

Kai Li,

Simiao Lu,

Changding Li

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 14, 2025

Background Esophageal squamous cell carcinoma (ESCC) is a common and aggressive form of esophageal cancer, particularly prevalent in East Asia. This study aimed to investigate the impact sex on clinical outcomes, including survival postoperative complications, elderly ESCC patients following esophagectomy. Methods We conducted retrospective cohort using data from Sichuan Cancer Hospital &amp; Institute Case Management Database, involving aged 70 years older who underwent esophagectomy May 2016 August 2021. Patients were grouped by sex, subgroup analyses performed non-smoking, non-drinking patients. OS DFS analyzed Kaplan-Meier method, between-group comparisons log-rank test. Propensity score matching (PSM) was applied adjust for potential confounders. Results Although females showed longer median (60.2 months) compared males (40.0 months), difference not statistically significant after PSM (HR = 0.885, P 0.573). Similarly, no differences observed between sexes. In subgroups, remained higher but without sex-based differences. Postoperative adverse events such as pulmonary infection anastomotic leakage across groups. Conclusions While does significantly affect patients, male may experience rates certain abnormal liver function pneumothorax.

Language: Английский

Citations

0
Disparity in trends and characteristics of early onset colorectal cancer: analysis from the National Inpatient Sample, 2016 to 2021 DOI
Thanathip Suenghataiphorn, Pojsakorn Danpanichkul,

Narathorn Kulthamrongsri

et al.

Baylor University Medical Center Proceedings, Journal Year: 2024, Volume and Issue: 37(6), P. 928 - 933

Published: Sept. 19, 2024

Colon cancer is the second most common cause of death in United States. With an increasing number patients diagnosed at younger ages, disease remains a significant burden. However, recent data on early onset admitted with colon are still limited.

Language: Английский

Citations

3
Bone Metastasis Mediates Poor Prognosis in Early‐Onset Gastric Cancer: Insights Into Immune Suppression, Coagulopathy, and Inflammation DOI Creative Commons

Shi Yin,

Xiaohui Zhai,

Yaoying Li

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(5)

Published: March 1, 2025

The increasing incidence of gastric cancer (GC) in younger populations, coupled with population aging, has highlighted distinct age-related subtypes unique clinical characteristics and outcomes. Although patients tend to have more aggressive tumors, the prognostic factors for early-onset (EOGC) remain underexplored. This study is dedicated providing a comprehensive in-depth analysis EOGC, aiming refine personalized treatment strategies under precision medicine paradigm. retrospective encompassed 413 local cohort EOGC 8447 Surveillance, Epidemiology, End Results database diagnosed GC. Survival outcomes were assessed using Kaplan-Meier survival curves, differences between groups evaluated log-rank test. Prognostic identified through logistic regression Cox proportional hazards models. Mediation was conducted assess indirect effects on prognosis. Biomarker comparisons bone metastasis non-bone Wilcoxon test significant differences. overall cancer-specific rates group significantly lower than those non-early-onset (p < 0.05). However, itself not an independent risk factor poor revealed that adverse impact prognosis predominantly mediated by metastasis, as most factor. Furthermore, emerged predictor patients, potentially linked elevated coagulation markers, increased inflammation-related cytokines, imbalance peripheral blood immune cell ratios. Bone contributes EOGC. demonstrate suppression, inflammation activation, coagulopathy, highlighting need tailored management strategies.

Language: Английский

Citations

0
Persistent Health Inequalities in the Burden of Gastrointestinal Cancers Among the Elderly From 1990 to 2021: A Population-Based Study DOI Creative Commons
Zijian Qiu,

S C Yu,

Y. Lou

et al.

Cancer Control, Journal Year: 2025, Volume and Issue: 32

Published: Feb. 1, 2025

Introduction Globally, aging populations highlight gastrointestinal cancers as a major public health concern. Our study aimed to quantify the trends and inequalities in burden of among elderly from 1990 2021. Methods Utilizing 2021 Global Burden Diseases (GBD) database, our secondary analysis targeted disability-adjusted life-years (DALYs) for (60+). DALYs are composite indicator loss, calculated sum years life lost due premature mortality lived with disability. The age-standardized rate (ASDR) was using direct standardization method. Trends were quantified by estimated annual percentage change ASDR. Slope index inequality (SII) concentration employed absolute relative inequalities. Results In 2021, colon rectum cancer (CRC) had highest global ASDR elderly, followed stomach (SC), esophageal (EC), pancreatic (PC), liver (LC), gallbladder biliary tract (GBTC). Between decreased globally, except PC. Health exhibited varied patterns: EC showed worsening lower SDI countries SII, while SC experienced shift higher SII. LC displayed an improving EC, SC, demonstrated transition towards countries. CRC, GBTC, PC maintained countries, SII reflected improvements inequality. Conclusion From substantial decline observed cancers, Persistent evolving need comprehensive, multi-level interventions reduce disparities achieve equitable outcomes all.

Language: Английский

Citations

0
Alcohol‐Attributable Cancer: Update From the Global Burden of Disease 2021 Study DOI
Pojsakorn Danpanichkul, Yanfang Pang, Luis Antonio Díaz

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

ABSTRACT Background and Aims Alcohol is a major risk factor for cancer development. Our study aimed to provide the updated global, regional national burden of alcohol‐attributable cancer. Approach Results We analysed Global Burden Disease Study 2021 determine death age‐standardised rate (ASDR) from change these measures between 2000 (reflected as annual percent [APC]), classified by region, nation country's developmental status, which based on sociodemographic index (SDI). In 2021, there were 343,370 deaths globally cancer, was an increase 51%. Alcohol‐attributable accounted 3.5% all deaths. Among liver (27%) highest mortality alcohol, followed oesophageal (24%) colorectal (16%). From ASDR decreased (APC: −0.66%). Regionally, fastest‐growing observed in South Asia. Classified SDI, low 0.33%) low‐to‐middle SDI countries 1.58%) exhibited uptrend While other cancers decreased, early‐onset (15–49 years) lip oral cavity increased 0.40%). Conclusions although declined, total number continued rise. This trend accompanied variations across groups types, particularly gastrointestinal cancers. Urgent efforts are needed both at levels address

Language: Английский

Citations

0
Early onset pancreatic cancer: A review DOI Creative Commons
Dong Luo, Xiaoping Yi,

Xiao Yu

et al.

Translational Oncology, Journal Year: 2024, Volume and Issue: 52, P. 102239 - 102239

Published: Dec. 12, 2024

Language: Английский

Citations

1
Comparison of postoperative survival prognosis between early-onset and late-onset esophageal cancer: A Population-based study DOI Creative Commons
Lang Qin, Jie Tian, Yuan Zhang

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0315391 - e0315391

Published: Dec. 12, 2024

The prognosis of non-distant metastatic early-onset esophageal cancer (EC) patients undergoing surgical treatment remains unclear, this study aims to compare the and late-onset EC. Information on EC who underwent were initially diagnosed between 2004 2015 was collected from Surveillance, Epidemiology, End Results (SEER) database. Propensity score matching (PSM) used balance baseline differences patients. Univariate multivariate Cox regression analyses calculate hazard ratio (HR) 95% confidence interval (CI). Kaplan-Meier method log-rank test overall survival (OS) two groups Atotal 5320 included, with 571 in group 4749 group. Multivariate analysis showed that had better OS (HR = 0.732, CI: 0.655-0.819, p<0.001). Using PSM at a 1:1 ratio, we matched 557 After matching, model still favorable for 0.728, 0.630-0.842, Additionally, subgroup indicated long-term prognosis. Non-distant demonstrated outcomes, confirmed by cohort.

Language: Английский

Citations

0