Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: July 1, 2024
This study aims to conduct a detailed bibliometric and visual analysis of acute kidney injury (AKI) immune-related research conducted over the past two decades, focusing on identifying emerging trends key areas interest.
Language: Английский
International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 54(4)
Published: Aug. 13, 2024
Adropin is a secreted peptide encoded by the energy homeostasis‑associated gene, which also functions as membrane‑bound protein facilitating intercellular communication. This has been detected in various tissues and body fluids, including brain, liver, kidney, heart, pancreas, small intestine, endothelial cells colostrum. Notably, amino acid sequences of adropin are identical humans, mice rats. Previous studies have demonstrated that levels fluctuate under different physiological pathological conditions. plays role regulating carbohydrate metabolism, lipid metabolism molecular signaling pathways, implicating its involvement progression numerous diseases, such acute myocardial infarction, lung injury, non‑alcoholic fatty liver disease/non‑alcoholic steatohepatitis, kidney disease, polycystic ovary syndrome, obesity, diabetes, atherosclerosis, systemic sclerosis cancer. Despite significance, precise mechanism this remain inadequately understood studied. To elucidate function clinical research status, systematic review recent on across diseases was conducted. Additionally, several challenges limitations associated with both animal contexts were identified, aiming to offer valuable insights for future investigation.
Language: Английский
Citations
7
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 19, 2025
Acute kidney injury (AKI) represents significant medical challenges due to its elevated rates of morbidity and mortality, with limited therapeutic options currently available. Hence, the exploration novel medicinal treatments for AKI management remains vital. Substances medicine food homology (SMFH), referring substances having characteristics both medicine, have been applied in China thousands years.They could be used daily diets body conditioning. Traditional Chinese (TCM), naturally derived components demonstrated effectiveness, presents distinctive benefits treatment. Numerous studies shown that SMFH TCM phytochemicals function satisfactorily nephroprotective effects a effect on alleviating as well complications. In this review, pathogenesis was illustrated. We concentrated against tried summarize underlying mechanisms various kinds AKI, highlighting crucial phytochemical prevention therapy. Besides, strategies globalization are analysed. This review comprehensively reveals exhibit promising potential intervention by targeting signal pathways targets, which would contribute AKI's cognition, preventive treatments, global promotion.
Language: Английский
Citations
0
Integrative Medicine in Nephrology and Andrology, Journal Year: 2025, Volume and Issue: 12(2)
Published: April 7, 2025
Background: Recent studies have been shown growing interest in gut microbiota and chronic kidney disease (CKD). Our preliminary found that Yishen Qingli Huoxue formula is effective treating CKD stage 3-5. However, there still individual variability comprehensive treatment regression. Previous indicated may be closely related to microbial enrichment or depletion. Methods: This study aimed characterize enterotypes patients with stages 3-5 construct partial microecological pathways for prevention treatment. The included 60 from the Department of Nephrology Jiangsu Provincial Hospital Chinese Medicine 30 controls who were recruited during same period. Classification was performed by partitioning around medoids (PAM) clustering algorithm based on genus level control as baseline. Information mining utilized analyze dependence enterotype environmental factors, marker genera corresponding different identified Tukey Honestly Significant Difference (HSD) Receiver Operating Characteristic (ROC) curve analysis. Results: Patients could categorized into three enterotypes, formation which weakly dependent factors. dominated commensal ( Bacteroides, Klebsiella ), conditionally pathogenic Escherichia-Shigella, Ruminococcus gnavus short-chain fatty acid-producing bacteria Bifidobacterium, Faecalibacterium respectively. They characterized Erysipelatoclostridium , Alistipes respectively, genera. Conclusion: standardization provides a basis precise intervention management traditional chinese medicine patients.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: July 1, 2024
This study aims to conduct a detailed bibliometric and visual analysis of acute kidney injury (AKI) immune-related research conducted over the past two decades, focusing on identifying emerging trends key areas interest.
Language: Английский
Citations
1