Parasite Epidemiology and Control, Journal Year: 2024, Volume and Issue: 27, P. e00390 - e00390
Published: Nov. 1, 2024
One of the major causes morbidity and death in children is malaria, HIV infection other factors may make situation worse. This study aimed to assess prevalence malaria parasitemia among HIV-infected under 15 years Bonassama Health District, Douala, Cameroon, investigate its association with CD4 cell counts, viral load, haematological parameters.
Language: Английский
International Journal of Medical Sciences and Pharma Research, Journal Year: 2024, Volume and Issue: 10(2), P. 18 - 25
Published: July 15, 2024
Maternal malaria, primarily caused by Plasmodium falciparum, has well-documented immediate effects on pregnancy, including preterm birth, low birth weight, and placental dysfunction. However, its impact extends beyond the current potentially influencing outcomes in subsequent pregnancies. This review examines how maternal malaria affects future pregnancies, focusing mechanisms through which previous infections contribute to complications. Key include chronic damage, immune system alterations, persistent inflammation, can disrupt function increase risk of adverse such as labor abruption The highlights evidence that women with a history are at an elevated for complications increased likelihood weight. Persistent damage dysregulation resulting from past these risks. Understanding long-term is crucial developing effective public health strategies interventions aimed mitigating risks pregnancy malaria-endemic regions. Keywords: complications, dysregulation,
Language: Английский
Citations
32
Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: April 3, 2024
Malaria remains a significant global health challenge, demanding deeper understanding of host immune responses for effective clearance the parasitic infection. Cytokines, as crucial mediators system, orchestrate complex interplay during various stages malaria Throughout course disease, an intricate balance pro-inflammatory and anti-inflammatory cytokines dictate response's outcome, influencing disease severity. During initial stages, interleukins such interleukin-12 (IL-12), interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) play pivotal roles in activating innate cells, initiating anti-parasitic response. Simultaneously, regulatory like interleukin-10 (IL-10) transforming growth factor-beta (TGF-β) modulate this activation, preventing excessive inflammation tissue damage. As infection progresses, delicate shift occurs, characterized by transition to adaptive immunity, guided interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13), promoting antibody production T-cell responses. Notably, resolution crucially relies on fine-tuned cytokine networks. Dysregulation or imbalances these often result hyperactivation, contributing severe manifestations prolonged Understanding multi-faceted offers promising avenues therapeutic interventions. Targeting pathways restore equilibrium bolster protective could potentially enhance treatment strategies vaccine development. In conclusion, role immunomodulation underscores their significance potential targets interventions, offering prospects fight against infectious disease.
Language: Английский
Citations
8
Medicine, Journal Year: 2024, Volume and Issue: 103(14), P. e37649 - e37649
Published: April 5, 2024
The co-occurrence of human immunodeficiency virus and malaria presents a complex medical scenario, significantly impacting the quality life for affected individuals. This comprehensive review synthesizes current knowledge, challenges, strategies concerning concurrent management these infections to improve overall well-being. Epidemiological insights reveal prevalence demographic trends, highlighting geographical areas concern socioeconomic factors contributing burden co-infection. Pathophysiological interactions elucidate compounding effects, altering disease progression treatment outcomes. Healthcare challenges underscore necessity integrated care models, evaluating existing healthcare frameworks their efficacy in addressing dual infections. In-depth analysis interventions explores pharmacological, behavioral, preventive measures, safety co-infected Additionally, assesses psychosocial support mechanisms, emphasizing community-based peer networks enhancing holistic care. Consideration is given role antiretroviral therapy, prevention strategies, evolving landscape delivery optimizing outcomes this vulnerable population. paper concludes by significance multidisciplinary approaches stressing need continued research collaborative efforts advance those navigating complexities
Language: Английский
Citations
4
Medicine, Journal Year: 2025, Volume and Issue: 104(1), P. e41222 - e41222
Published: Jan. 3, 2025
Cytokines, critical signaling molecules in the immune system, significantly influence pathophysiology of Human Immunodeficiency Virus (HIV) infection and effectiveness antiretroviral therapy (ART). Dysregulated cytokine production, characterized by elevated pro-inflammatory anti-inflammatory cytokines, plays a pivotal role chronic inflammation activation untreated HIV patients. ART initiation leads to changes levels, typically resulting decreased systemic inflammation, though extent persistence these vary among individuals. Despite successful viral suppression with ART, many patients experience persistent driven ongoing dysregulation. This inflammatory state is associated adverse clinical outcomes, including cardiovascular disease, neurocognitive impairment, non-AIDS-related cancers. Understanding specific profiles that contribute outcomes crucial for developing targeted therapeutic interventions improve long-term health. Cytokine modulation presents promising avenue enhancing recovery reducing on ART. Identifying patterns serve as biomarkers disease progression treatment response can help tailor individualized strategies. Future research should focus adjunctive therapies target activity mitigate residual thereby improving overall health quality life
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 9, 2025
Language: Английский
Citations
0
OBM Genetics, Journal Year: 2025, Volume and Issue: 09(02), P. 1 - 39
Published: April 1, 2025
Since the initial discovery of CRISPR system in bacteria as an adaptive immune system, a deeper understanding structure and function has made it possible to perform gene editing, therapy, revolutionize diagnostic field. One exciting applications CRISPR-Cas is used tool for rapid diagnosis infectious diseases their treatment prevention infection spread among people. The CRISPR-based could be next-generation standard because its programmability capability searching target sequence quickly, making diagnose infections at lower cost but with same accuracy conventional methods. In this review, data were collected from valid papers published PubMed/Medline, Google Scholar, GISAID, Wiley Online Library, Web Science, ResearchGate databases. We have discussed novel various that routinely soon.
Language: Английский
Citations
0
Academia Medicine, Journal Year: 2024, Volume and Issue: 1(2)
Published: April 29, 2024
Childhood anemia persists as a global health concern, with heightened significance in regions endemic to malaria.This review synthesizes current knowledge on the strategies used address childhood malaria-prone areas, examining complex interplay between these two challenges.The epidemiology of malaria-endemic is explored, emphasizing impact malaria development.Existing interventions, including antimalarial drugs, nutritional supplements, and preventive measures, are critically assessed.Despite progress, challenges management persist, driven by issues healthcare access, socioeconomic factors, evolving strains.The advocates for integrated approaches multidisciplinary collaboration multifaceted nature problem.Future directions, emerging trends innovations, discussed, offering insights into potential transformative improved pediatric outcomes malariaaffected regions.This comprehensive analysis contributes ongoing dialogue mitigating context guides future research intervention efforts.
Language: Английский
Citations
3
Haematology International Journal, Journal Year: 2024, Volume and Issue: 8(1)
Published: Jan. 1, 2024
Human Immunodeficiency Virus (HIV) infection poses unique challenges during pregnancy, affecting maternal health and potentially impacting the developing fetus. This systematic review explores intricate relationship between HIV eosinophils, a critical component of immune system, pregnancy. As induces immunosuppression, understanding its specific effects on eosinophil levels is crucial for predicting outcomes vertical transmission risks. The also delves into potential influence antiretroviral therapy modulating function. By synthesizing existing literature, this aims to provide comprehensive complex interplay infection, offering insights future research directions therapeutic interventions.
Language: Английский
Citations
2
Asian Journal of Dental and Health Sciences, Journal Year: 2024, Volume and Issue: 4(1), P. 38 - 44
Published: March 15, 2024
Natural disasters pose unique challenges to individuals living with HIV/AIDS, impacting their mental health and psychosocial well-being. This review explores the complex interplay between natural implications for HIV patients. Disruptions in healthcare infrastructure, medication access, treatment continuity during significantly affect disease management, leading heightened stress, anxiety, trauma among this vulnerable population. Social support networks, crucial those HIV, often suffer severe setbacks, exacerbating issues. The aftermath of may induce long-term psychological effects, including post-traumatic stress disorder (PTSD) depression. Understanding these multifaceted impacts is critical developing tailored interventions systems mitigate consequences experienced by wake disasters. Further research targeted are essential address specific needs population promote resilience face such calamities. Keywords: health, effect, disaster, AIDS, emergency
Language: Английский
Citations
2
Haematology International Journal, Journal Year: 2024, Volume and Issue: 8(1)
Published: Jan. 1, 2024
Human Immunodeficiency Virus (HIV) infection remains a global health challenge, characterized by progressive immune dysregulation leading to acquired immunodeficiency syndrome (AIDS). Among the myriad alterations observed in HIV, dysfunction of B lymphocytes plays significant role disease progression. This review article critically examines multifaceted cells during HIV infection, encompassing altered phenotypes, impaired functions, and disrupted interactions within microenvironment. The involves diverse mechanisms, including direct viral effects, chronic activation, cytokine milieu. Such manifests as compromised antibody production, perturbed cell subsets, memory responses, aberrant secretion, contributing diminished humoral immunity dysregulation. Understanding these intricacies is pivotal for elucidating pathogenesis developing targeted therapeutic strategies. paper delineates implications HIV-associated therapies. It highlights promising approaches, immunotherapies targeting function modulation, potential modifications or adjunctive therapies alongside standard antiretroviral therapy (ART) address abnormalities, innovative strategies aimed at restoring HIV-infected individuals. elucidation offers unique avenue interventions. Targeting not only aims restore but also holds promise ameliorating overall function, potentially augmenting current treatment paradigms.
Language: Английский
Citations
1