Ethanol crude leaf extract of weeping fig (Ficus benjamina) causes mild hepatotoxicity in Sprague dawley rats DOI Creative Commons
Mfoniso Udonkang, L. Douglas, Raymond Ekong Eworo

et al.

INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY, Journal Year: 2024, Volume and Issue: 6(2), P. 85 - 94

Published: Oct. 24, 2024

Weeping fig (Ficus benjaminaeaf extract has diverse medicinal properties but little is reported about its hepatotoxicity. This study determined the mean lethal dose (LD50) and investigated effects of F. benjamina ethanol crude leaf on biochemical parameters liver histology Sprague Dawley rats. Twenty-nineemale rats weighing 133-204 g were used. The LD50 was with nine based Lorke’s method. experimental groups consisted twenty rats, divided into four five. Each group received treatment as follows: Control (feed water only) low, medium, high doses (500, 1000, 1500 mg/kg respectively) orally for 21 days. All animals weighed sacrificed using Ketamine intra-peritoneal injection. Blood samples collected total bilirubin, conjugated aspartate aminotransferase (AST) alanine (ALT), alkaline phosphatase (ALP). Liver tissues removed processed by formalin-fixed-paraffin wax-embedding tissue blocks sectioned subjected to Hematoxylin/Eosin Masson trichrome staining. extract’s >5000 mg/kg. rats’ body weights did not change statistically (p=0.985). Total bilirubin (p=0.003), AST, ALT, ALP values (p=0.001) increased significantly. AST high-doseroup had highest fold increase (4.8). showed mild sinusoidal dilation at 500 There marked hemorrhage fibrosis medium doses. Although relatively low acute toxicity, 1000 associated hepatotoxicity characterized veno-occlusion disease. safer purposes.

Language: Английский

Enhancing the Physicochemical Stability and Bioaccessibility of Curcumin-loaded Soybean Oil Bodies Emulsions in the in vitro Elderly Model DOI
Wenwen Lv,

Kaiyi Zou,

Fengru Zhang

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 158, P. 110563 - 110563

Published: Aug. 24, 2024

Language: Английский

Citations

10
Very-Low-Absorbable Geraniol for the Treatment of Irritable Bowel Syndrome: A “Real-World” Open-Label Study on 1585 Patients DOI Open Access
Chiara Ricci, Ilaria Maria Saracino, Maria Chiara Valerii

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 328 - 328

Published: Jan. 17, 2025

The objective of this study was to evaluate the efficacy a very-low-absorbable geraniol formulation, administered as food supplement, in patients with irritable bowel syndrome (IBS) real-world setting Italy. This open-label conducted Italy on diagnosed IBS and treated for 4 weeks 240 mg/day Palmarosa essential oil, absorbed 960 mg ginger root powder obtain formulation. Baseline characteristics, including demographic symptoms were recorded using Severity Scoring System (IBS-SSS). After 28 ± 7 days, asked complete IBS-SSS questionnaire again. primary confirm effects formulation self-reported quality life affected individuals. secondary effect treatment different subtypes. A total 1585 included study, mean age 44.8 years 56.4% women. Following 4-week supplementation period, significant decreases observed patients' (-67.9%) all symptoms, such abdominal distention (-82.3%), unsatisfaction habits (-46.2%), interference (QoL) (-64.9%) (all p < 0.01). stool type improved significantly. Treatment effective very-low-adsorbable supplement associated improvements subtypes These findings support use an option regardless disease subtype.

Language: Английский

Citations

0
Safety evaluation of ethanolic extract from aerial flowering part of spiny globe thistle (Echinops spinosus) in mice: Phytochemical screening and genotoxicity DOI
Kawthar A. Diab, Maha A. Fahmy, Entesar E. Hassan

et al.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Journal Year: 2025, Volume and Issue: 902, P. 503854 - 503854

Published: Feb. 1, 2025

Language: Английский

Citations

0
Manejo y planificación de cuidados paliativos en paciente con cirrosis hepática en el ámbito comunitario DOI Creative Commons
Elizabeth Miranda Velázquez,

Jefferson Joel Pardo Cheverría,

José Manuel Reyes Romero

et al.

LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades, Journal Year: 2025, Volume and Issue: 6(1)

Published: Feb. 6, 2025

Desarrollar un enfoque integral y plan de cuidados estandarizados tanto cuidado directo atención calidad, para el manejo paciente en paliativos desde punto vista enfermería medicina, mediante la implementación estrategias interdisciplinarias con recursos comunitarios. Para presente estudio caso se seleccionó cirrosis hepática estadio final que recibió primaria oportuna, donde firmó consentimiento informado entrevista directa, revisión historia clínica, antecedentes patológicos, familiares, quirúrgicos, tratamientos diagnósticos previos. En realizó entrevistas planificadas estructuradas los cuidadores. Las intervenciones paliativas aplicadas, mejoraron significativamente calidad vida del sus cuidadores 75% relación al inicio su tratamiento, demostrando interdisciplinario tiene mejores resultados ámbito comunitario personalizados. Desde medicina las personalizadas acorde a necesidades salud puede mejorar gran significancia darle una más humanizada, vez crea planes estratégicos cuidador sea partícipe mantener familiar educación capacitación continua referente patología posibles complicaciones estas pueden traer. Mediante digno holístico.

Citations

0
Natural Alkaloids Modulating Macrophage Polarization: Innovative Therapeutic Strategies for Inflammatory, Cardiovascular, and Cancerous Diseases DOI
Jing Lü, Minghao Yin, Yixuan Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156709 - 156709

Published: April 1, 2025

Language: Английский

Citations

0
Ethanol crude leaf extract of weeping fig (Ficus benjamina) causes mild hepatotoxicity in Sprague dawley rats DOI Creative Commons
Mfoniso Udonkang, L. Douglas, Raymond Ekong Eworo

et al.

INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY, Journal Year: 2024, Volume and Issue: 6(2), P. 85 - 94

Published: Oct. 24, 2024

Weeping fig (Ficus benjaminaeaf extract has diverse medicinal properties but little is reported about its hepatotoxicity. This study determined the mean lethal dose (LD50) and investigated effects of F. benjamina ethanol crude leaf on biochemical parameters liver histology Sprague Dawley rats. Twenty-nineemale rats weighing 133-204 g were used. The LD50 was with nine based Lorke’s method. experimental groups consisted twenty rats, divided into four five. Each group received treatment as follows: Control (feed water only) low, medium, high doses (500, 1000, 1500 mg/kg respectively) orally for 21 days. All animals weighed sacrificed using Ketamine intra-peritoneal injection. Blood samples collected total bilirubin, conjugated aspartate aminotransferase (AST) alanine (ALT), alkaline phosphatase (ALP). Liver tissues removed processed by formalin-fixed-paraffin wax-embedding tissue blocks sectioned subjected to Hematoxylin/Eosin Masson trichrome staining. extract’s >5000 mg/kg. rats’ body weights did not change statistically (p=0.985). Total bilirubin (p=0.003), AST, ALT, ALP values (p=0.001) increased significantly. AST high-doseroup had highest fold increase (4.8). showed mild sinusoidal dilation at 500 There marked hemorrhage fibrosis medium doses. Although relatively low acute toxicity, 1000 associated hepatotoxicity characterized veno-occlusion disease. safer purposes.

Language: Английский

Citations

0