Cited by Brazilin-Rich Extract from <i>Caesalpinia sappan</i> L. Attenuated the Motor Deficits and Neurodegeneration in MPTP/p-Induced Parkinson’s Disease Mice by Regulating Gut Microbiota and Inhibiting Inflammatory Responses

Metabolomics in Parkinson’s Disease and Correlation with Disease State DOI

Elena A. Ostrakhovitch, Kenjiro Ono, Tritia R. Yamasaki

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 208 - 208

Published: March 18, 2025

Changes in the level of metabolites, small molecules that are intermediates produced by metabolism or catabolism, associated with developing diseases. Metabolite signatures body fluids such as plasma, cerebrospinal fluid, urine, and saliva Parkinson’s disease. Here, we discuss alteration metabolites TCA cycle, pentose phosphate pathway, kynurenic network, redox system. We also summarize efforts many research groups to differentiate between metabolite profiles characterize PD motor progression dyskinesia, gait balance, non-motor symptoms depression cognitive decline. Understanding how changes lead may allow for identification individuals at earliest stage disease development new therapeutic strategies.

Language: Английский

Citations

Lipid metabolism: Novel approaches for managing idiopathic epilepsy DOI

Chao Wang, Jinxia Zhai,

Xuemei Zhou

et al.

Neuropeptides, Journal Year: 2024, Volume and Issue: 108, P. 102475 - 102475

Published: Sept. 30, 2024

Language: Английский

Citations

Gut Microbiome and Its Role in Parkinson's Disease DOI

Suchith B Suresh,

Aparna Malireddi,

Mahlet Abera

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Parkinson's disease (PD) afflicted more than 8.5 million people globally in 2019, as the prevalence of condition doubled during preceding 25 years. Both non-motor symptoms, such mood disorders and cognitive impairment, motor tremors rigidity, are indicative this progressive neurodegenerative disease. Recent data indicates a significant role for gut microbiome PD pathogenesis progression, emphasizing microbiota-gut-brain axis. In compliance with Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) 2020 statement, systematic review summarizes our current knowledge about function PD, highlighting recurrent microbial alterations assessing microbiome-based treatment strategies. The revealed several consistent patterns microbiota patients, including reduced diversity specific taxonomic alterations, drop Firmicutes abundance an increase Proteobacteria abundance. Functional changes microbiome, altered short-chain fatty acid (SCFA) production tryptophan metabolism, were also noted. These observed even early-stage drug-naïve suggesting they not merely consequence progression or medication use. highlighted potential mechanisms linking to increased intestinal permeability, neuroinflammation, modulation alpha-synuclein aggregation. Probiotics, prebiotics, fecal transplantation few interventions that try modify might be possible halt advancement enhance patients' quality life condition. Future research should focus on establishing causality through large-scale longitudinal studies, standardizing analysis methods, exploring personalized therapies.

Language: Английский

Citations

Brazilin-Rich Extract from Caesalpinia sappan L. Attenuated the Motor Deficits and Neurodegeneration in MPTP/p-Induced Parkinson’s Disease Mice by Regulating Gut Microbiota and Inhibiting Inflammatory Responses DOI

Wen Gao,

Xinni Wu,

Yang Wang

et al.

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Parkinson's disease (PD) is a complicated neurological with an unclear pathogenesis. However, dysregulation of gut microbiota and inflammation response play crucial roles in the progression PD.

Language: Английский

Citations