Identification of Clinical Value and Biological Effects of TTN Mutation in Hepatocellular Carcinoma DOI Creative Commons

Zhixue Zhang,

Yating Sun, Zhirui Zeng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Hepatocellular carcinoma (HCC) is a malignant tumor of the digestive system and one leading causes cancer mortality worldwide. So far, various genetic mutations have been observed in hepatocellular related with tumorigenesis due to genomic instability. However, clinical characteristic therapeutic value HCC were extent unknown. In present study, by analyzing gene mutation landscape tissues from TCGA database, we demonstrated that TTN (titin) was high-frequency HCC, relevant poor prognosis HCC. had no relationship immune signature but linked change drug sensitivity GSK1904529A, nilotinib, 5-Fluorouracil (5-FU) sapitinib. Furthermore, through performing TIDE algorithm, CCK-8 assays, colony formation cell sphere-forming experiment, vivo transplantation experiment biological experiments investigated association between sensitivity. We found led increased stability protein, which depletion results decrease intracellular ferrous ion content, inhibiting ferroptosis pathway, significantly reduced 5-FU vitro vivo. These findings cause reduce 5-FU, reducing treatment efficacy. conclusion, our studies provided initial evidences can sever as biomarker for predicting prognosis, signature, molecular targets therapy It provides new idea solving resistance response treatment. Background: Methods: database Results: The research identified And leads decreasing levels, pathway. Conclusions: high frequency genes promotes protein stability, demonstrate weaken providing target address therapy.

Language: Английский

Comprehensive analysis of CLEC family genes in gastric cancer prognosis immune response and treatment DOI Creative Commons
Weijian Zhu,

Qiang Yi,

Jiaqi Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Identification of Clinical Value and Biological Effects of TTN Mutation in Hepatocellular Carcinoma DOI Creative Commons

Zhixue Zhang,

Yating Sun, Zhirui Zeng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Hepatocellular carcinoma (HCC) is a malignant tumor of the digestive system and one leading causes cancer mortality worldwide. So far, various genetic mutations have been observed in hepatocellular related with tumorigenesis due to genomic instability. However, clinical characteristic therapeutic value HCC were extent unknown. In present study, by analyzing gene mutation landscape tissues from TCGA database, we demonstrated that TTN (titin) was high-frequency HCC, relevant poor prognosis HCC. had no relationship immune signature but linked change drug sensitivity GSK1904529A, nilotinib, 5-Fluorouracil (5-FU) sapitinib. Furthermore, through performing TIDE algorithm, CCK-8 assays, colony formation cell sphere-forming experiment, vivo transplantation experiment biological experiments investigated association between sensitivity. We found led increased stability protein, which depletion results decrease intracellular ferrous ion content, inhibiting ferroptosis pathway, significantly reduced 5-FU vitro vivo. These findings cause reduce 5-FU, reducing treatment efficacy. conclusion, our studies provided initial evidences can sever as biomarker for predicting prognosis, signature, molecular targets therapy It provides new idea solving resistance response treatment. Background: Methods: database Results: The research identified And leads decreasing levels, pathway. Conclusions: high frequency genes promotes protein stability, demonstrate weaken providing target address therapy.

Language: Английский

Citations

0